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New partnership to develop test for predicting disease course in pediatric Crohn's patients

The Crohn's & Colitis Foundation, the leading non-profit organization focused on both research and patient support for inflammatory bowel disease (IBD), has entered into a partnership with LifeArc, an independent medical research charity that advances translation of early science into health care treatments or diagnostics, to potentially develop the first clinical lab test to predict disease course in pediatric patients with Crohn's disease and response to treatment.

25 Jan 2021

Probiotics as adjuvant therapy for COVID-19 patients

In a recent review published in the Journal of Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Luigi Santacroce and Francesco Inchingolo et al. address the many factors such as dysbiosis (imbalance in the microbiota) that could influence the SARS-CoV-2 infection course.

25 Jan 2021

Study finds high prevalence of cardiovascular conditions in male breast cancer patients

Male breast cancer patients were found to have a high prevalence of cardiovascular conditions, in a small study of this rare patient population presented at the American College of Cardiology's Advancing the Cardiovascular Care of the Oncology Patient Virtual course.

25 Jan 2021

Stem cell based cell culture model to recapitulate important aspects of NAFLD

Nonalcoholic fatty liver disease (NAFLD) is a widespread condition in the Western World. Around 30% of the population have lipid droplets stored in their liver which diminish its function in the long term.

25 Jan 2021

New method can help identify potential anti-cancer drugs at a high pace

The enzymes in human cells known as histone deacetylases, or HDACs, are targets for a handful of anticancer drugs because of their ability to affect gene expression.

25 Jan 2021

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

The cover for issue 2 of Oncotarget features Figure 4, "Combination therapy TA99/ICB reduced the lung tumor burden in the B16 model of metastases," published in "Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma" by Pérez-Lorenzo, et al. which reported that here, the authors showed that removing immune suppression and enhancing stimulatory signals increased the anti-tumor activity of unmodified TA99 antibodies with a significant reduction of growth of solid tumors and lung metastases in mouse models of melanoma.

25 Jan 2021

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. which reported that the authors conducted a genome-wide analysis of DNA methylation of the tumor and non-tumor tissue of 15 patients with Hepatocellular carcinoma (HCC), and revealed TBX15 was the most hypermethylated gene of the tumor.

25 Jan 2021

Socioeconomic conditions linked to high viral load despite treatment for HIV patients in Ethiopia

For those who are diagnosed and have begun treatment for HIV, it is standard practice to regularly monitor viral load in the blood to assess response to treatment.

25 Jan 2021

Second-generation double antibody protects from SARS-CoV-2 and its tested variants

The Institute for Research in Biomedicine (IRB; Bellinzona, Switzerland), affiliated to the Università della Svizzera italiana (USI) developed a second-generation 'double antibody' that protects from SARS-CoV-2, the virus causing COVID-19, and all its tested variants. It also prevents the virus from mutating to resist the therapy.

24 Jan 2021

New maintenance treatment for AML shows strong benefit for patients

Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of the cancer drug azacitidine as a maintenance treatment, according to a randomized, international phase 3 clinical trial for which Weill Cornell Medicine and NewYork-Presbyterian are trial sites.

22 Jan 2021

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

Researchers from Queen Mary University of London, have identified a protein that may represent a novel therapeutic target for the treatment of pancreatic cancer.

22 Jan 2021

UC researchers test new combination therapy for head and neck cancer in animal models

Head and neck cancer is the sixth most common cancer worldwide, and while effective treatments exist, sadly, the cancer often returns.

22 Jan 2021

NCCN provides new guidance for COVID-19 vaccinations in people with cancer

The National Comprehensive Cancer Network put out new information today to provide guidance for COVID-19 vaccinations in people with cancer.

22 Jan 2021

Combination therapy shows potential for treating lung cancer

Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment.

22 Jan 2021

Digital twin approach for cardiology opens up new possibilities in clinical diagnostics

Using mathematical image processing, scientists at the BioTechMed-Graz research cooperation have found a way to create digital twins from human hearts. The method opens up completely new possibilities in clinical diagnostics.

22 Jan 2021

Physical exercise helps improve mobility, increase quality of life of patients with chronic kidney disease

An improved physical condition with these exercises helps improve mobility in certain daily activities, increasing the quality of life of people with chronic kidney disease.

22 Jan 2021

SMART recovery groups provide addiction services during COVID-19 pandemic

The COVID-19 pandemic has created new perils and challenges for people experiencing substance use disorders and addictive behaviors. Social distancing and isolation can trigger loneliness, anxiety, and depression.

22 Jan 2021

Infusion of convalescent blood plasma benefits patient with severe COVID-19

A 72-year-old woman was hospitalized with severe COVID-19 disease, 33 days after the onset of symptoms.

22 Jan 2021

Modified version of CAR T-cell therapy shows promise in targeting neuroblastoma

Chimeric Antigen Receptor T-cell therapy--CAR T--has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma.

22 Jan 2021

Researchers develop comprehensive framework to classify small-cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study published today in Cancer Cell.

22 Jan 2021

Therapy News and Research

New partnership to develop test for predicting disease course in pediatric Crohn's patients

Probiotics as adjuvant therapy for COVID-19 patients

Study finds high prevalence of cardiovascular conditions in male breast cancer patients

Stem cell based cell culture model to recapitulate important aspects of NAFLD

New method can help identify potential anti-cancer drugs at a high pace

Combining anti-tumor antibodies with standard-of-care improves therapeutic outcomes in cancer

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

Socioeconomic conditions linked to high viral load despite treatment for HIV patients in Ethiopia

Second-generation double antibody protects from SARS-CoV-2 and its tested variants

New maintenance treatment for AML shows strong benefit for patients

Researchers identify protein that may represent a safer treatment target for pancreatic cancer

UC researchers test new combination therapy for head and neck cancer in animal models

NCCN provides new guidance for COVID-19 vaccinations in people with cancer

Combination therapy shows potential for treating lung cancer

Digital twin approach for cardiology opens up new possibilities in clinical diagnostics

Physical exercise helps improve mobility, increase quality of life of patients with chronic kidney disease

SMART recovery groups provide addiction services during COVID-19 pandemic

Infusion of convalescent blood plasma benefits patient with severe COVID-19

Modified version of CAR T-cell therapy shows promise in targeting neuroblastoma

Researchers develop comprehensive framework to classify small-cell lung cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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