Antibodies News and Research

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Novavax announces positive results in trial of seasonal influenza VLP (trivalent) vaccine candidate

Novavax, Inc. has announced favorable results from a Phase IIa human clinical trial of its seasonal influenza VLP (trivalent) vaccine candidate.

12 Dec 2008

Enzyme that mutates antibodies also targets cancer-causing gene

The human immune system is in a perpetual state of self-experimentation. It expertly mutates and shuffles the DNA of its own cells to evolve new defenses against the vast array of microbes that try to invade our bodies.

12 Dec 2008

Enzyme that mutates antibodies also targets a cancer-causing oncogene

Rockefeller University scientists have discovered that the same enzyme that enables the immune system's defensive creativity is also responsible for a particular genetic malfunction - a translocation of one piece of DNA to the wrong chromosome - that causes Burkitt's lymphoma.

12 Dec 2008

Mathematical models of adaptive immunity

More than five million people die every year from infectious diseases, despite the availability of numerous antibiotics and vaccines. The discovery of penicillin to treat bacterial infections, along with the development of vaccines for previously incurable virus diseases such as polio and smallpox, achieved great reductions in mortality during the mid-20th century.

11 Dec 2008

An enzyme that mutates antibodies also targets a cancer-causing oncogene

11 Dec 2008

Blocking immune receptor molecule improves response to HIV-like virus, prolongs survival in monkeys

By blocking PD-1 (programmed death-1), an immune receptor molecule known to inhibit the immune response to chronic viral infections, scientists have safely and significantly reduced the plasma viral load and also prolonged survival of rhesus macaque monkeys severely infected with simian immunodeficiency virus (SIV), the nonhuman primate version of human immunodeficiency virus (HIV).

10 Dec 2008

Xencor presents data on anti-CD19 and anti-CD40 antibodies

Xencor, Inc. presented results Sunday at the 50th Annual Meeting of the American Society of Hematology from pre-clinical studies evaluating XmAb 5574, a monoclonal antibody engineered using Xencor's XmAb Fc technologies that targets the antigen CD19.

10 Dec 2008

Vaccine against malaria could be ready in 5 years

Malaria kills more than one million people every year so the news that an effective vaccine could be available within five years is more than welcome.

9 Dec 2008

Half-dose vaccination in healthy young individuals may be effective in times of vaccine shortage

Individuals younger than 50 who have been previously vaccinated do not appear to have a substantially different immune response to a half-dose of influenza vaccine than to a full dose, according to a report in the December 8/22 issue of Archives of Internal Medicine.

8 Dec 2008

MedImmune starts phase 2 trial of antibody targeting IL-5 receptor

MedImmune has announced that it has initiated a Phase 2 clinical trial in patients with chronic asthma to determine the safety of subcutaneous dosing of a humanized monoclonal antibody (MAb) that targets the interleukin-5 receptor (IL-5R).

8 Dec 2008

Childhood obesity may change thyroid

In addition to its strong associations with hypertension, cardiovascular disease, and diabetes, pediatric obesity may induce alterations in thyroid function and structure, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

3 Dec 2008

New vaccine theory aimed at ticks and mosquitoes to prevent disease transmission

Most successful vaccines and drugs rely on protecting humans or animals by blocking certain bacteria from growing in their systems.

3 Dec 2008

Prototype blood scanner detects even faint indicators of cancer

A team led by Stanford researchers has developed a prototype blood scanner that can find cancer markers in the bloodstream in early stages of the disease, potentially allowing for earlier treatment and dramatically improved chances of survival.

3 Dec 2008

New study indicates smallpox vaccination effective for decades

Although naturally occurring smallpox was eradicated in 1977, there is concern that bioterrorists might obtain smallpox from a laboratory and release it into the population.

30 Nov 2008

Research identifies cell receptor as target for anti-inflammatory immune response

Cell reception. By comparing normal mice (left) with mice that are genetically engineered to lack certain receptors in their spleen (right), scientists have shown SIGNR1 receptors (blue) are required to facilitate an anti-inflammatory action.

28 Nov 2008

Discovery of new way in which epigenetic information is inherited

Hereditary information flows from parents to offspring not just through DNA but also through the millions of proteins and other molecules that cling to it.

28 Nov 2008

MorphoSys and Galapagos enter alliance to co-develop novel therapeutic antibodies in bone and joint disease

MorphoSys AG and Galapagos NV announced today the launch of a long term co-development alliance aimed at discovering and developing antibody therapies based on novel modes of action in bone and joint disease, including rheumatoid arthritis, osteoporosis and osteoarthritis.

26 Nov 2008

Researchers generate synthetic SARS-like bat coronavirus

SARS - severe acute respiratory syndrome - alarmed the world five years ago as the first global pandemic of the 21st century.

25 Nov 2008

Peregrine Pharmaceuticals awarded U.S. patent for anti-viral applications of phospholipid-targeting antibodies

Peregrine Pharmaceuticals, Inc. has announced that the U.S. Patent and Trademark Office has issued U.S. Patent Number No. 7,455,833, which includes broad claims covering anti-viral applications of antibodies that directly bind to aminophospholipids.

25 Nov 2008

Dieters could have a harder time fighting flu

In a study published in the November issue of the Journal of Nutrition, Gardner showed that mice with a calorie-restricted diet were more likely to die during the first few days of infection than mice with a normal diet. Caloric restriction is the practice of reducing the intake of calories to 40 percent of a normal diet, while maintaining adequate vitamins and minerals.

25 Nov 2008

Antibodies News and Research

Novavax announces positive results in trial of seasonal influenza VLP (trivalent) vaccine candidate

Enzyme that mutates antibodies also targets cancer-causing gene

Enzyme that mutates antibodies also targets a cancer-causing oncogene

Mathematical models of adaptive immunity

An enzyme that mutates antibodies also targets a cancer-causing oncogene

Blocking immune receptor molecule improves response to HIV-like virus, prolongs survival in monkeys

Xencor presents data on anti-CD19 and anti-CD40 antibodies

Vaccine against malaria could be ready in 5 years

Half-dose vaccination in healthy young individuals may be effective in times of vaccine shortage

MedImmune starts phase 2 trial of antibody targeting IL-5 receptor

Childhood obesity may change thyroid

New vaccine theory aimed at ticks and mosquitoes to prevent disease transmission

Prototype blood scanner detects even faint indicators of cancer

New study indicates smallpox vaccination effective for decades

Research identifies cell receptor as target for anti-inflammatory immune response

Discovery of new way in which epigenetic information is inherited

MorphoSys and Galapagos enter alliance to co-develop novel therapeutic antibodies in bone and joint disease

Researchers generate synthetic SARS-like bat coronavirus

Peregrine Pharmaceuticals awarded U.S. patent for anti-viral applications of phospholipid-targeting antibodies

Dieters could have a harder time fighting flu

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