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Single dose of intraoperative radiotherapy effective for early stage breast cancer patients

In the South East of England, a patient experience study of 18 early stage breast cancer patients who opted for single dose intraoperative radiotherapy, found positive patient reported outcomes for this alternative to standard daily external beam radiotherapy.

21 Apr 2016

Scientists discover CD2AP protein that plays key role in nervous system

University of Louisville researchers have discovered that a protein previously known for its role in kidney function also plays a significant role in the nervous system. In an article featured in the April 13 issue of the Journal of Neuroscience, they show that the adaptor protein CD2AP is a key player in a type of neural growth known as collateral sprouting.

21 Apr 2016

Plastic surgeons develop new SADIE flap procedure to reconstruct breast after mastectomy

UT Southwestern Medical Center plastic surgeons have developed a new breast reconstruction technique that combines advantages of two different types of microsurgical procedures using abdominal and other tissue to reconstruct the breast after a mastectomy.

20 Apr 2016

Experimental treatment shrinks rare pediatric tumor by 90%

When a baby's life was threatened by a rare pediatric cancer that would not respond to surgery or chemotherapy, doctors at Nemours Children's Hospital rapidly, successfully shrank the tumor by 90 percent using an experimental treatment, according to a new study published online in Pediatric Blood and Cancer.

20 Apr 2016

CWRU scientists develop computational tools to quantify effects of prostate cancer laser ablation

Prostate cancers are either low-grade, low-risk forms that may be monitored but otherwise untreated. Or they're serious enough to require surgery and radiation.

20 Apr 2016

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy.

20 Apr 2016

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

The immunotherapy drug nivolumab has become the first to show a survival benefit in head and neck cancer, after a major international trial found that it was more effective than standard chemotherapy.

20 Apr 2016

Researchers examine effectiveness of antipsychotic drugs to prevent or treat delirium

In a study published in the Journal of the American Geriatrics Society, researchers examined whether or not antipsychotic drugs, which are sometimes used to prevent or treat delirium, are effective.

20 Apr 2016

New drug combination before surgery may improve outcomes in breast cancer patients

Results from the I-SPY 2 trial show that giving patients with HER2-positive invasive breast cancer a combination of the drugs trastuzumab emtansine (T-DM1) and pertuzumab before surgery was more beneficial than the combination of paclitaxel plus trastuzumab.

19 Apr 2016

Well-established optics technique can locate brain tumors within a minute compared to conventional methods

When operating on cancer, surgeons want to remove tumors and not healthy tissue. This is especially important and challenging when dealing with brain tumors, which are often spread out and mixed in with the healthy tissue. Now, researchers have shown that a well-established optics technique can reveal exactly where brain tumors are, producing images in less than a minute -- unlike conventional methods that can take a whole day.

19 Apr 2016

SBRT for prostate cancer treatment offers higher cure rate than many traditional approaches

A five-year study shows that Stereotactic Body Radiation Therapy (SBRT) to treat prostate cancer offers a higher cure rate than more traditional approaches, according to researchers at UT Southwestern Medical Center Harold C. Simmons Comprehensive Cancer Center.

19 Apr 2016

Delay in radiation therapy increases chances of DCIS recurrence in women

Delaying radiation therapy too long after surgery significantly increases the risk of recurrent tumors in women treated for very early, or what is referred to as "stage 0," breast cancer, according to new research at Washington University School of Medicine in St. Louis.

19 Apr 2016

Study shows women may face decreased kidney damage from ischemia reperfusion injury

After a kidney transplant, women may experience decreased kidney damage from ischemia reperfusion injury compared to men due to the impact of gender-specific hormones, suggests a new preclinical study and an analysis of patient data published online in the Journal of Clinical Investigation from researchers at the Perelman School of Medicine at the University of Pennsylvania.

19 Apr 2016

Transplanted human islets prevent hypoglycemic events in Type 1 diabetes patients

Northwestern Medicine researchers are co-investigators in a breakthrough clinical trial that found transplanted human islets prevent hypoglycemic events and provide excellent glycemic control for patients with Type 1 diabetes with severe hypoglycemia.

19 Apr 2016

Inhibiting adrenaline receptors reduces breast cancer brain metastases

While we look to invent new medicines to treat cancer, a parallel approach to repurpose existing medicines may be highly effective. Stress, mediated by adrenaline, has been suspected to promote cancer growth and this research study shows that by blocking adrenaline receptors in breast cancers, they are less successful in spreading to and growing in the brain.

19 Apr 2016

Animal study links female resilience to renal ischemia with protective effects of estrogen

Kidney transplantation outcomes are adversely affected by ischemia-reperfusion injury, which occurs as a result of blood flow restrictions during the reperfusion stage of transplant surgery.

19 Apr 2016

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI-110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

18 Apr 2016

Report highlights parlous state of British children's teeth

The Local Government Association has today published a report that states that around 100 children and teenagers a day are being admitted to hospital for surgery to remove rotten teeth.

18 Apr 2016

Study indicates mRS is poorly suited to evaluate, report quality of neuro-surgery

Surgery has become a volatile field during the past few years, with study after study challenging prevailing treatment practices. For example, surgical treatment of acute appendicitis and arthroscopic surgery on degenerative knees have been called into question by recent research results reached by Finnish researchers.

18 Apr 2016

New study shows only half of locally advanced rectal cancer patients receive standard therapy

While use of the standard therapy leading to the best outcome against locally advanced rectal cancer has increased over the past decade, only half of patients currently receive it, according to a new study. The authors of the study say the underutilization could be explained in part by socioeconomic factors. The study appears early online in the American Cancer Society's peer-review journal Cancer.

16 Apr 2016

Surgery News and Research

Single dose of intraoperative radiotherapy effective for early stage breast cancer patients

Scientists discover CD2AP protein that plays key role in nervous system

Plastic surgeons develop new SADIE flap procedure to reconstruct breast after mastectomy

Experimental treatment shrinks rare pediatric tumor by 90%

CWRU scientists develop computational tools to quantify effects of prostate cancer laser ablation

Immunotherapy drug pembrolizumab shrinks tumors in patients with Merkel cell carcinoma

Nivolumab drug shows survival benefit in phase III trial of patients with head and neck cancer

Researchers examine effectiveness of antipsychotic drugs to prevent or treat delirium

New drug combination before surgery may improve outcomes in breast cancer patients

Well-established optics technique can locate brain tumors within a minute compared to conventional methods

SBRT for prostate cancer treatment offers higher cure rate than many traditional approaches

Delay in radiation therapy increases chances of DCIS recurrence in women

Study shows women may face decreased kidney damage from ischemia reperfusion injury

Transplanted human islets prevent hypoglycemic events in Type 1 diabetes patients

Inhibiting adrenaline receptors reduces breast cancer brain metastases

Animal study links female resilience to renal ischemia with protective effects of estrogen

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

Report highlights parlous state of British children's teeth

Study indicates mRS is poorly suited to evaluate, report quality of neuro-surgery

New study shows only half of locally advanced rectal cancer patients receive standard therapy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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