Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Immunity following COVID-19 vaccination and natural infection in India

The researchers evaluated immune response markers in a cross-section of people from the Indian state of West Bengal, including those vaccinated with either Covishield or Covaxin, the unvaccinated cohort, and the naturally infected.

11 Nov 2021

Effectiveness of sotrovimab demonstrated in patients with mild to moderate COVID-19

In an attempt to study the safety and effectiveness of sotrovimab in more vulnerable patients suffering from mild to moderate symptoms of COVID-19, a multinational team of researchers conducted the COVID-19 Monoclonal antibody Efficacy Trial-Intent to Care Early (COMET-ICE) trial.

11 Nov 2021

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

A German case study recently published in the journal Nature Communications has characterized a long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics in an immunosuppressed kidney transplant recipient and provided evidence for the evolution of SARS-CoV-2 into potentially harmful immune escape mutants during persistent infections.

10 Nov 2021

Current understanding of the link between COVID-19 and cardiovascular disease

A review published in Chemo-Biological Interactions has focused on the prevalence of COVID-19 in CVD patients associated with ACE2 mechanisms.

10 Nov 2021

Mechanisms and strategies for antibody binding and escape in SARS-CoV-2

A new study investigated the mechanisms for binding and strategies to escape several hNAbs used by SARS-CoV-2 strains through molecular simulations.

10 Nov 2021

A measles-vectored COVID-19 vaccine induces strong immunity in animal model

A new study explores the potential of MV-based vaccines targeting the S protein of SARS-CoV-2.

9 Nov 2021

COVID-19 and loss of sense of smell

A recent review examines the high susceptibility of the olfactory epithelium to SARS-CoV-2 infection.

9 Nov 2021

The role of T follicular helper cells in the humoral immune response to SARS-CoV-2

The current analysis indicates that cTfh cells react to the spike antigen following vaccination are associated with anti-S protein neutralizing antibodies.

9 Nov 2021

Pregnant women’s humoral response is dependent on SARS-CoV-2 strain

The current study from Israel discusses the change in antibody response with the trimester of infection and the infecting variant.

9 Nov 2021

SARS-CoV-2 infection in white-tailed deer

In the current study, SARS-CoV-2 antibodies were identified in over a third of free-ranging deer in northeast Ohio.

9 Nov 2021

SARS-CoV-2 leaves long-term impact on olfactory neurocircuit

The current study looked at the impact of the virus on the CNS in the Syrian golden hamster, a useful animal model for COVID-19.

9 Nov 2021

Novel tetravalent antibodies for the ultrapotent and broad neutralization of SARS-CoV-2 variants

Researchers from the University of Toronto set out to create a new tetravalent antibody that could bind with enough potency that it could remain effective against VOCs.

9 Nov 2021

Scientists develop a high-throughput, cell-free screening platform for anti-SARS-CoV-2 antibody discovery

Scientists from Northwestern University, USA, have recently developed a high-throughput, automated screening platform to rapidly identify anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. The study is currently available on the bioRxiv* preprint server.

8 Nov 2021

Trial compares renal denervation to a sham procedure for treatment-resistant hypertension

Six-month outcomes from the randomized RADIANCE-HTN TRIO Trial comparing endovascular ultrasound renal denervation (RDN) to a sham procedure for treatment-resistant hypertension (HTN) found that the addition of a pharmacologic intervention led to further blood pressure reductions after RDN with a smaller increase in additional medications prescribed and less use of diuretics.

8 Nov 2021

Discovery of potent neutralizing antibodies against SARS-CoV-2 variants

Pre-clinical follow-up study boosting with original formulation and next generation INO-4802 SARS-CoV-2 vaccine candidate

Researchers describe the antibody-inducing effects of DNA-based synthetic vaccines INO-4800 and INO-4802 against SARS-CoV-2 in non-human primates.

3 Nov 2021

Angiotensin News and Research

Further Reading

Immunity following COVID-19 vaccination and natural infection in India

Effectiveness of sotrovimab demonstrated in patients with mild to moderate COVID-19

Emergence of SARS-CoV-2 immune escape variants in an immunocompromised patient

Current understanding of the link between COVID-19 and cardiovascular disease

Mechanisms and strategies for antibody binding and escape in SARS-CoV-2

A measles-vectored COVID-19 vaccine induces strong immunity in animal model

COVID-19 and loss of sense of smell

The role of T follicular helper cells in the humoral immune response to SARS-CoV-2

Pregnant women’s humoral response is dependent on SARS-CoV-2 strain

SARS-CoV-2 infection in white-tailed deer

SARS-CoV-2 leaves long-term impact on olfactory neurocircuit

Novel tetravalent antibodies for the ultrapotent and broad neutralization of SARS-CoV-2 variants

Scientists develop a high-throughput, cell-free screening platform for anti-SARS-CoV-2 antibody discovery

Trial compares renal denervation to a sham procedure for treatment-resistant hypertension

Discovery of potent neutralizing antibodies against SARS-CoV-2 variants

Study finds SARS-CoV-2 infection of endothelial cells unlikely

Convalescent plasma post-vaccination increases binding and neutralizing antibodies against SARS-CoV-2 variants

“Catching SARS-CoV-2 in the act” – viral infection of nasal mucosa spares nerve cells

SARS-CoV-2 detected in white-tailed deer with possible zooanthroponotic spillover events

Pre-clinical follow-up study boosting with original formulation and next generation INO-4802 SARS-CoV-2 vaccine candidate

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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