Antiretroviral News and Research

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Study: Fewer Americans control their HIV infections

Tens of thousands of Americans taking potent antiretroviral therapies, or ART, to keep their HIV disease in check may not have as much control over the viral infection as previous estimates have suggested, according to results of a study by AIDS experts at Johns Hopkins and the University of Pennsylvania.

23 Jul 2012

Implementing multifaceted global effort may help end global HIV/AIDS pandemic

Ending the global HIV/AIDS pandemic may be possible by implementing a multifaceted global effort that expands testing, treatment, and prevention programs, as well as meets the scientific challenges of developing an HIV vaccine and possibly a cure, according to a Viewpoint in the July 25 issue of JAMA, a theme issue on HIV/AIDS.

23 Jul 2012

All adult patients with HIV should be offered ART: International Antiviral Society-USA panel

Included in the 2012 International Antiviral Society-USA panel recommendations for human immunodeficiency virus (HIV) patient care is that all adult patients, regardless of CD4 cell count, should be offered antiretroviral therapy (ART), according to an article in the July 25 issue of JAMA, a theme issue on HIV/AIDS.

23 Jul 2012

Study addresses African patients’ attitudes toward HIV antiretroviral therapy

An ongoing clinical study in rural Uganda, begun in 2011, suggests that many people infected with HIV/AIDS would take antiretroviral drugs if they were available to them—even before they developed symptoms from the disease.

23 Jul 2012

Targeting monocyte activation may reduce arterial inflammation in HIV-infected patients

The elevated risk of cardiovascular disease seen in patients infected with HIV appears to be associated with increased inflammation within the arteries, according to a study that will appear in a special issue of JAMA published in conjunction with the International AIDS Conference.

23 Jul 2012

As AIDS conference opens, health panel urges treatment of all HIV infections

An international health panel has recommended for the first time that all HIV patients be treated with antiretroviral drugs, even when the virus's impact on their immune system is shown to be small. The nonprofit International Antiviral Society-USA cited new evidence that untreated infection with the human immunodeficiency virus that causes AIDS can also lead to a range of other conditions, including cardiovascular disease and kidney disease.

23 Jul 2012

Researchers identify high ARV drug exposure in hair samples of HIV uninfected infants

Researchers from the University of California, San Francisco (UCSF) and Makerere University in Uganda have used hair and blood samples from three-month old infants born to HIV-positive mothers to measure the uninfected babies' exposure—both in the womb and from breast-feeding—to antiretroviral medications their mothers were taking. The results, they said, are surprising.

23 Jul 2012

New CHAIT initiative on development of novel immunological therapeutic interventions

The CHAIT initiative is a public-private partnership focusing on the development of novel immunological therapeutic interventions to achieve a 'functional HIV cure' with the ultimate goal of HIV eradication.

21 Jul 2012

Domestic PEPFAR program would increase coordination, improve AIDS response in U.S.

"Urban America continues to suffer high rates of HIV despite successes of antiretroviral treatment that can suppress the virus, decrease transmission, prevent progression to AIDS, and lower death rates," Gregory Pappas, senior deputy director of the Washington, D.C., Department of Health's HIV/AIDS, Hepatitis, STD and TB Administration (HAHSTA), writes in a Washington Blade opinion piece.

21 Jul 2012

New WHO guidance recommends use of ARVs for HIV prevention

WHO has issued its first guidance to countries that are considering offering HIV medications, known as antiretrovirals (ARVs), to protect people who do not have the virus but who are at high risk of HIV infection.

21 Jul 2012

Cipla, DNDi to develop ARV combination therapy for children with HIV/AIDS

On the eve of the XIX International AIDS Conference in Washington, DC, the Drugs for Neglected Diseases initiative (DNDi), a not-for-profit research and development (R&D) organization, announces a new collaboration with Indian drug manufacturer Cipla to develop and produce an improved first-line antiretroviral (ARV) combination therapy specifically adapted to meet the treatment needs of infants and toddlers living with HIV/AIDS.

21 Jul 2012

Funding must support optimism surrounding HIV prevention, treatment

The goal of an "AIDS-free generation" "requires an ambitious implementation-science agenda that improves efficiency and effectiveness and incorporates strategies for overcoming the stigma and discrimination that continue to limit the uptake and utilization of treatment, prevention and care services," AIDS 2012 Co-Chair Diane Havlir of the University of California-San Francisco School of Medicine and Chris Beyrer of the Johns Hopkins Center for AIDS Research write in a New England Journal of Medicine opinion piece.

20 Jul 2012

American leadership on HIV/AIDS making a difference in U.S. and abroad

"As two people who worked as physicians in the early years of the HIV/AIDS epidemic before the miracle of antiretroviral drug (ARV) therapy, and who now have the honor of leading the domestic and global HIV/AIDS programs for the Obama administration, we look back in awe of the American leadership that has transformed the epidemic in the 22 years since the International AIDS Conference was last held on U.S. soil," Grant Colfax, director of the Office of National AIDS Policy, and U.S. Global AIDS Coordinator Ambassador Eric Goosby write in a Washington Blade opinion piece.

20 Jul 2012

Natural compound can virtually eradicate HIV in infected culture cells

A new study by scientists on the Florida campus of The Scripps Research Institute shows, in cell culture, a natural compound can virtually eliminate human immunodeficiency virus (HIV) in infected cells. The compound defines a novel class of HIV anti-viral drugs endowed with the capacity to repress viral replication in acutely and chronically infected cells.

20 Jul 2012

UNAIDS releases report highlighting gains, gaps in global HIV/AIDS response

Ahead of the XIX International AIDS Conference next week, UNAIDS on Wednesday launched a new report, titled "Together we will end AIDS", "that shows that a record eight million people are now receiving antiretroviral therapy [ARVs], and that domestic funding for HIV has exceeded global investments," the U.N. News Centre reports.

20 Jul 2012

HIV in MSM increasing in countries of all incomes

A new Lancet Series published to coincide with the AIDS2012 meeting highlights a population where the HIV epidemic is growing in countries of all incomes: men who have sex with men (MSM). The first paper in the Series charts the epidemiology of HIV among MSM, and is by Professor Chris Beyrer, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA, and colleagues.

20 Jul 2012

ARV drug resistance levels steady in low-, middle-income countries, WHO report says

More widespread use of antiretroviral drugs (ARVs) to treat HIV infection has led to drug resistance in low- and middle-income countries, but the level "is not steep enough to cause alarm, said a survey released by the World Health Organization on Wednesday," Agence France-Presse reports.

20 Jul 2012

Community-based resources in rural Uganda can successfully provide HIV treatments

New research from the University of Alberta's School of Public Health has demonstrated that community-based resources in rural Uganda can successfully provide HIV treatments to patients, where economic and geographical barriers would typically prevent access to care.

20 Jul 2012

International Partnership for Microbicides CEO discusses research in GlobalPost interview

GlobalPost's "Global Pulse" blog features an interview with Zeda Rosenberg, CEO of the International Partnership for Microbicides (IPM), in which she discusses a study of a vaginal ring containing the antiretroviral (ARV) dapivirine.

20 Jul 2012

Viewpoints: Researchers see potential to control HIV pandemic; The 'ceaseless attacks' on women's reproductive health

We are at a moment of extraordinary optimism in the response to the human immunodeficiency virus (HIV). A series of scientific breakthroughs ... have the potential to markedly expand the available preventive tools. There is evidence of the first cure of an HIV-infected person. And most important, the finding that early initiation of antiretroviral therapy can both improve individual patient outcomes and reduce the risk of HIV transmission to sexual partners by 96% has led many to assert what had so long seemed impossible: that control of the HIV pandemic may be achievable.

20 Jul 2012

Antiretroviral News and Research

Study: Fewer Americans control their HIV infections

Implementing multifaceted global effort may help end global HIV/AIDS pandemic

All adult patients with HIV should be offered ART: International Antiviral Society-USA panel

Study addresses African patients’ attitudes toward HIV antiretroviral therapy

Targeting monocyte activation may reduce arterial inflammation in HIV-infected patients

As AIDS conference opens, health panel urges treatment of all HIV infections

Researchers identify high ARV drug exposure in hair samples of HIV uninfected infants

New CHAIT initiative on development of novel immunological therapeutic interventions

Domestic PEPFAR program would increase coordination, improve AIDS response in U.S.

New WHO guidance recommends use of ARVs for HIV prevention

Cipla, DNDi to develop ARV combination therapy for children with HIV/AIDS

Funding must support optimism surrounding HIV prevention, treatment

American leadership on HIV/AIDS making a difference in U.S. and abroad

Natural compound can virtually eradicate HIV in infected culture cells

UNAIDS releases report highlighting gains, gaps in global HIV/AIDS response

HIV in MSM increasing in countries of all incomes

ARV drug resistance levels steady in low-, middle-income countries, WHO report says

Community-based resources in rural Uganda can successfully provide HIV treatments

International Partnership for Microbicides CEO discusses research in GlobalPost interview

Viewpoints: Researchers see potential to control HIV pandemic; The 'ceaseless attacks' on women's reproductive health

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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