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Genetic cause of progressive hearing loss discovered

A team led by scientists from The Scripps Research Institute has discovered a genetic cause of progressive hearing loss. The findings will help scientists better understand the nature of age-related decline in hearing and may lead to new therapies to prevent or treat the condition.

4 Sep 2009

Phase I clinical trial data of GDC-0449 published in the New England Journal Of Medicine

Curis, Inc. (NASDAQ: CRIS), a drug development company focused on developing proprietary targeted medicines for cancer treatment, today announced that two publications describing clinical data generated with GDC-0449 were published in the current edition of The New England Journal of Medicine (NEJM).

3 Sep 2009

Study reports a potential new investigational therapy for skin cancer

A study published today in the New England Journal of Medicine reports a potential new investigational therapy for advanced and metastatic basal cell skin cancer tested at the Virginia G. Piper Cancer Center at Scottsdale Healthcare and other sites appears to demonstrate tumor shrinkage and limited side effects in patients.

3 Sep 2009

Gloucester’s romidepsin recommended for approval by the FDA Oncologic Drug Advisory Committee

Gloucester Pharmaceuticals announced today that the Oncologic Drug Advisory Committee (ODAC) appointed by the U.S. Food and Drug Administration (FDA) voted 10 in favor with one abstention to recommend approval of romidepsin to treat patients with cutaneous T-cell lymphoma (CTCL). CTCL is a type of non-Hodgkin's lymphoma, which is a cancer of the immune system.

3 Sep 2009

GDC-0449 inhibits the Hedgehog signaling pathway

The Hedgehog signaling pathway is involved in a preliminary study and case report describing positive responses to an experimental anticancer drug in a majority of people with advanced or metastatic basal cell skin cancers. One patient with the most common type of pediatric brain cancer, medulloblastoma, also showed tumor shrinkage.

3 Sep 2009

New therapy for advanced and metastatic basal cell skin cancer

3 Sep 2009

LINGO1 variant responsible for essential tremors and Parkinson's disease

Researchers at the Mayo Clinic campus in Florida and their collaborators worldwide have discovered that a single gene promotes development of essential tremor in some patients and Parkinson's disease in others.

2 Sep 2009

Linkwell concerned with misunderstanding of prevention and control measures of H1N1

Linkwell Corporation (OTC Bulletin Board: LWLL), a leading developer, manufacturer and distributor of healthcare-related disinfectants in China, put forward its worries about the trend of the misunderstanding concerning dealing with the spread of H1N1.

2 Sep 2009

Genes that regulate the energy consumption of cells have a different structure and expression in diabetics

Genes that regulate the energy consumption of cells have a different structure and expression in type II diabetics than they do in healthy people, according to a new study from the Swedish medical university Karolinska Institutet published in Cell Metabolism.

2 Sep 2009

New computer software capable of sifting through hundreds of cancer causing genetic mutations

Johns Hopkins engineers have devised innovative computer software that can sift through hundreds of genetic mutations and highlight the DNA changes that are most likely to promote cancer.

1 Sep 2009

Altered gene network interaction plays an important role in brain tumors

The interaction between a network of altered genes appears to play an important role in the development and progression of brain tumors, according to a study in the July 15 issue of JAMA.

1 Sep 2009

Correlation between overweight, smoking and breast cancer discovered

A recent study published in the Journal of Cancer Epidemiology has reinforced the correlation between being overweight, smoking and breast cancer. What makes this study unique is how test subjects were not diagnosed for BRCA1 and BRCA2 gene mutations, which predispose women to breast cancer.

1 Sep 2009

MultiGEN Diagnostics launches new technology for clinical testing in molecular diagnostics

San Diego-based MultiGEN Diagnostics Inc. has launched a novel multi-target DNA sequencing technology (MultiGEN) for a wide range of clinical testing in molecular diagnostics.

1 Sep 2009

Study provides insights into genes that help maintain youthfulness of the skin

In the new print issue of Nature Genetics, scientists in Singapore and Germany report that mutations in the PYCR1 gene cause the rare genetic condition that results in premature skin aging and that is known as "wrinkly skin syndrome."

1 Sep 2009

ViraCor-IBT Laboratories launches new influenza and respiratory virus testing service

ViraCor-IBT Laboratories today launched a new, comprehensive influenza and respiratory virus testing service that will assist physicians in detecting a range of respiratory viruses including 2009 Influenza A H1N1, or “swine flu,” as well as other influenza subtypes and common respiratory viruses such as rhinovirus, respiratory syncytial virus (RSV) and human metapneumovirus (HMPV).

31 Aug 2009

Fluidigm manufactures more than 250 million microscopic NanoFlex valves at its Singapore biochip factory

Fluidigm today announced that its Singapore biochip factory has manufactured and shipped more than 250 million microscopic NanoFlex™ valves. The 250 million valves built into Fluidigm’s integrated fluidic circuits (IFCs) would be equivalent to the number of valves required for all the conventional plumbing – both residential and commercial – in a metropolitan region the size of the San Francisco Bay Area.

27 Aug 2009

Lakewood-Amedex to speed up development of its broad spectrum anti-influenza product into clinical studies

Lakewood-Amedex Inc., (L-A), the anti-infectives biopharmaceutical company developing a unique portfolio of anti-bacterial and anti-viral products including NuBiotics, a novel family of synthetic anti-bacterial compounds, and anti-viral products against hepatitis, HIV and influenza, announced today that it is accelerating development of its broad spectrum anti-influenza product into clinical studies.

27 Aug 2009

Mutations associated with prion diseases are sufficient to cause transmissible neurodegenerative disease

For the first time, Whitehead Institute researchers have shown definitively that mutations associated with prion diseases are sufficient to cause a transmissible neurodegenerative disease.

26 Aug 2009

Viral polymerase may provide a new therapeutic target for host-adapted avian influenza

Current research suggests that viral polymerase may provide a new therapeutic target for host-adapted avian influenza. The related report by Gabriel et al, "Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus" appears in the September 2009 issue of the American Journal of Pathology.

26 Aug 2009

Anti-glycan antibody positivity observed in celiac disease

Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet. The importance of newly discovered inflammatory bowel disease-associated antibodies (including anti-glycan antibodies and anti-OMP) in celiac disease is not sure.

26 Aug 2009

Mutation News and Research

Genetic cause of progressive hearing loss discovered

Phase I clinical trial data of GDC-0449 published in the New England Journal Of Medicine

Study reports a potential new investigational therapy for skin cancer

Gloucester’s romidepsin recommended for approval by the FDA Oncologic Drug Advisory Committee

GDC-0449 inhibits the Hedgehog signaling pathway

New therapy for advanced and metastatic basal cell skin cancer

LINGO1 variant responsible for essential tremors and Parkinson's disease

Linkwell concerned with misunderstanding of prevention and control measures of H1N1

Genes that regulate the energy consumption of cells have a different structure and expression in diabetics

New computer software capable of sifting through hundreds of cancer causing genetic mutations

Altered gene network interaction plays an important role in brain tumors

Correlation between overweight, smoking and breast cancer discovered

MultiGEN Diagnostics launches new technology for clinical testing in molecular diagnostics

Study provides insights into genes that help maintain youthfulness of the skin

ViraCor-IBT Laboratories launches new influenza and respiratory virus testing service

Fluidigm manufactures more than 250 million microscopic NanoFlex valves at its Singapore biochip factory

Lakewood-Amedex to speed up development of its broad spectrum anti-influenza product into clinical studies

Mutations associated with prion diseases are sufficient to cause transmissible neurodegenerative disease

Viral polymerase may provide a new therapeutic target for host-adapted avian influenza

Anti-glycan antibody positivity observed in celiac disease

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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