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Artificial circular RNAs found to bypass cellular antiviral responses

Researchers produced artificial circular ribonucleic acid sponges in a permuted intron-exon system and showed that these did not activate innate immunity.

29 Apr 2022

Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

In a new study, researchers described their self-designed chimeric receptor-binding domain-dimer vaccine approach to adapt SARS-CoV-2 variants of concern and variants of interest.

29 Apr 2022

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Researchers examined the efficiency of the main protease (Mpro) inhibitor against SARS-CoV-2.

29 Apr 2022

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

A recent study published in the journal Immunology analyzed whether sex mattered in the immune response to SARS-CoV-2.

29 Apr 2022

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

A new study published in Marine Drugs evaluated the inhibitory effect of three polysaccharides, crude polysaccharide from Hizikia fusiforme (CPHF), crude polysaccharide from Sargassum horneri (CPSH), and crude polysaccharide from abalone viscera (CPAV) on the propagation of SARS-CoV-2 in vitro.

28 Apr 2022

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

All humans carry genetic variations in their DNA, called Single Nucleotide Polymorphisms (SNPs) that can underlie susceptibility to diseases such as diabetes and cancer.

28 Apr 2022

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Certain childhood tumors have an extreme need for amino acids. Scientists at the Hopp Children's Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg, and HI-STEM gGmbH have now discovered the molecular mechanisms underlying this and how the cancer cells could be turned off.

28 Apr 2022

Unraveling how strigoractone hormone regulates massive gene networks controlling plant growth

As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond to the environment and integrate the signals from outside with endogenous developmental programs.

28 Apr 2022

UrFU researchers propose the use of polyoxometallate nanoclusters as chemotherapy drug carrier

Researchers at Ural Federal University have proposed the use of polyoxometallate nanoclusters as a carrier for chemotherapy drug. It will help to deliver medications precisely to the focus of a pathological process, such as a cancerous tumor, without toxic effects on healthy cells.

28 Apr 2022

Lipofilling produces lasting improvements for patients with painful finger osteoarthritis

For patients with painful finger osteoarthritis, a nonsurgical procedure called lipofilling – in which fat obtained from another part of the body is transferred into the arthritic joints – produces lasting improvements in hand function and especially pain, suggests a study in the May issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

28 Apr 2022

NIH awards $10.9 million COBRE grant to support Nemours Children's 'well beyond medicine' strategy

The National Institutes of Health (NIH) recently awarded a Phase 1, 5-year $10.9 million Center of Biomedical Research Excellence (COBRE) award, entitled Research Expanding Access to Child Health (REACH) Center to Anne Kazak, PhD, Enterprise Director, and Melissa Alderfer, PhD, Director of the Center for Healthcare and Delivery Science (CHDS) at Nemours Children's Health.

28 Apr 2022

New insights into how NANOG protein facilitates the activation of human cell pluripotency

There are cells in the body known as pluripotent stem cells that are yet to specialize in a particular biological function.

28 Apr 2022

Novel method could bring life-saving benefits of CAR T-cell therapy to patients with acute myeloid leukemia

Massachusetts General Hospital researchers have developed a novel treatment strategy that has the potential to bring the life-saving benefits of chimeric antigen receptor T-cell therapy (CAR T) to patients with acute myeloid leukemia (AML) the most common form of leukemia in adults.

28 Apr 2022

Tufts scientists discover a previously unknown function performed by astrocytes

Researchers at Tufts University School of Medicine have discovered a previously unknown function performed by a type of cell that comprises nearly half of all cells in the brain.

28 Apr 2022

Sleep deprivation negatively affects the stem cells in the cornea

Sleep deprivation, which means getting too little high-quality sleep, is a serious health problem. More than one-third of people in the USA report getting less than the recommended minimum of seven hours sleep per night.

28 Apr 2022

Black and Hispanic people get the same benefits from CAR-T therapy as white patients

CAR-T therapy, a form of immunotherapy that revs up T-cells to recognize and destroy cancer cells, has revolutionized the treatment of blood cancers, including certain leukemias, lymphomas, and most recently, multiple myeloma.

28 Apr 2022

Researchers create 3D in vitro model that reveals the origins of human spine

The spinal column is the central supporting structure of the skeleton in all vertebrates. Not only does it provide a place for muscles to attach, it also protects the spinal cord and nerve roots. Defects in its development are known to cause rare hereditary diseases.

28 Apr 2022

B Cell News and Research

Artificial circular RNAs found to bypass cellular antiviral responses

Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

Study reports an orally available SARS-CoV-2 Mpro inhibitor with potent in vivo antiviral activity

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

Researchers discover molecular mechanisms underlying extreme need for amino acids in neuroblastoma

Unraveling how strigoractone hormone regulates massive gene networks controlling plant growth

UrFU researchers propose the use of polyoxometallate nanoclusters as chemotherapy drug carrier

Lipofilling produces lasting improvements for patients with painful finger osteoarthritis

NIH awards $10.9 million COBRE grant to support Nemours Children's 'well beyond medicine' strategy

New insights into how NANOG protein facilitates the activation of human cell pluripotency

Novel method could bring life-saving benefits of CAR T-cell therapy to patients with acute myeloid leukemia

Tufts scientists discover a previously unknown function performed by astrocytes

Sleep deprivation negatively affects the stem cells in the cornea

Black and Hispanic people get the same benefits from CAR-T therapy as white patients

Researchers create 3D in vitro model that reveals the origins of human spine

Study shows how DNA changes in Barrett's esophagus cells may predict esophageal cancer

Therapeutic promise of CAR-T cell bispecific engagers against SARS-CoV-2

How do mosquito bites affect immunity?

Immunology eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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