Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Understanding SARS-CoV-2-induced systemic amyloidosis

A new study proposed that inflammation combined with aggregates of amyloidogenic peptides of SARS-CoV-2 S proteins might induce systemic amyloidosis.

21 Dec 2021

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Interesting research decrypts a recurring sequence in antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) and identifies it to be a board neutralizing antibody that targets a conserved epitope on the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein.

21 Dec 2021

Research reveals the structure and function of a bifunctional protein that transports heme

Heme is an essential part of the protein hemoglobin, which colors human blood red. Heme also is crucial for cytochrome proteins, which power the cell. Humans, animals, plants and bacteria all use heme.

21 Dec 2021

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer's disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer's prevention trials, this one will enroll people before the disease has taken hold - up to 25 years before the expected onset of dementia.

21 Dec 2021

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

Overweight or obesity, an unfavorable distribution of fat in the body and the development of type 2 diabetes are often associated with a reduced effect of the hormone insulin in many organs, including the brain (insulin resistance).

21 Dec 2021

New method to detect SARS-CoV-2 helps get reliable results more quickly

You're worried that you may have been exposed to the coronavirus, so you decide to take a test. But which do you choose?

21 Dec 2021

Study analyzes the role of circular RNA in ALS pathology

Amyotrophic lateral sclerosis, known as ALS, is a neurodegenerative disorder which affects motor neurons. These are the neuronal cells responsible for muscle innervation, whose degenerations leads to progressive paralysis culminating with motor and respiratory failure.

21 Dec 2021

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

In a new study, published on the bioRxiv* preprint server, scientists showed in a mice model that three doses of the same synthetic peptide vaccine, eliciting an exclusive CD8+ T cell response against one SARS-CoV-2 Spike epitope, protected against lethal SARS-CoV-2 infection, in the absence of neutralizing antibodies. Researchers also showed that the third dose resulted in superior generation of effector-memory T cells in the circulation and tissue-resident memory T (TRM) cells.

20 Dec 2021

An Omicron wave predicted for England from December 2021 to April 2022

A study, published on the medRxiv* preprint server, focuses on the interaction between Omicron variants and public health interventions in England that promote immunity.

20 Dec 2021

New oral pill for COVID-19 home treatment

As cases and hospitalizations continue to rise in many countries, new treatments are being sought to arrest the progression of the disease, preventing severe illness and death or disability. One such is the small molecule molnupiravir, the focus of a new research paper.

20 Dec 2021

QTQTN motif upstream of furin-cleavage site in SARS-CoV-2 infection and pathogenesis

A new study posted to the bioRxiv* preprint server aimed to demonstrate whether the loss of the QTQTN motif attenuates SARS-CoV-2 replication in respiratory cells in vitro and pathogenesis in hamsters.

20 Dec 2021

New study suggests most monoclonal antibody treatments are ineffective against Omicron SARS-CoV-2 variant

The arrival of the Omicron (B.1.1.529) variant has brought into question the effectiveness of current COVID-19 treatments in preventing infection and death. New research published in the preprint bioRxiv* server suggests the efficacy of most monoclonal antibody treatments are ineffective against Omicron.

20 Dec 2021

New Omicron variant may be better at evading vaccine-induced antibodies, research shows

The Omicron variant of SARS-CoV-2 may be significantly better than previous variants at evading vaccine-induced antibodies, according to new research from Cambridge - but preliminary evidence suggests it is less likely to cause severe COVID-19 illness in the lungs.

20 Dec 2021

U-M scientists develop a cell-free artificial cortex to study how cells divide

Animal cells are bound by a structure called a cell cortex—and this structure, researchers say, is a bit like a tent.

20 Dec 2021

Omicron variant of SARS-CoV-2 exhibits striking antibody evasion

Researchers discuss the likely impact on current convalescent therapies and immunity of vaccinated individuals against the SARS-CoV-2 Omicron variant.

20 Dec 2021

UBR7 protein acts as a histone chaperone during DNA replication, study finds

The protein UBR7 acts as a histone chaperone, regulating histone re-deposition at specific sites during DNA replication, according a recent study published in The EMBO Journal.

20 Dec 2021

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Researchers conduct a comprehensive in vitro analysis of relatively unexplored host immune responses during SARS-CoV-2 infection.

20 Dec 2021

White-tailed deer are efficient carriers of SARS-CoV-2

Researchers demonstrate the susceptibility of white-tailed deer to SARS-CoV-2.

20 Dec 2021

New tool provides an unprecedented view of brain cell activity in a synapse

To solve the mysteries of how learning and memory occur, Johns Hopkins Medicine scientists have created a system to track millions of connections among brain cells in mice — all at the same time — when the animals' whiskers are tweaked, an indicator for learning.

20 Dec 2021

Reduced antibody-mediated neutralization by the SARS-CoV-2 Omicron variant

Researchers discuss the sensitivity of the SARS-CoV-2 Omicron variant towards various monoclonal antibodies.

20 Dec 2021

Protein News and Research

Further Reading

Understanding SARS-CoV-2-induced systemic amyloidosis

Identifying a recurring pattern in broadly neutralizing antibodies that can target an epitope on SARS-CoV-2

Research reveals the structure and function of a bifunctional protein that transports heme

Study focuses on inherited Alzheimer’s up to 25 years before expected dementia onset

SGLT2 inhibitor empagliflozin can be used to treat insulin resistance in the brain, finds study

New method to detect SARS-CoV-2 helps get reliable results more quickly

Study analyzes the role of circular RNA in ALS pathology

Booster shots improve CD8+ T cell response to SARS-CoV-2 in animal model

An Omicron wave predicted for England from December 2021 to April 2022

New oral pill for COVID-19 home treatment

QTQTN motif upstream of furin-cleavage site in SARS-CoV-2 infection and pathogenesis

New study suggests most monoclonal antibody treatments are ineffective against Omicron SARS-CoV-2 variant

New Omicron variant may be better at evading vaccine-induced antibodies, research shows

U-M scientists develop a cell-free artificial cortex to study how cells divide

Omicron variant of SARS-CoV-2 exhibits striking antibody evasion

UBR7 protein acts as a histone chaperone during DNA replication, study finds

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

White-tailed deer are efficient carriers of SARS-CoV-2

New tool provides an unprecedented view of brain cell activity in a synapse

Reduced antibody-mediated neutralization by the SARS-CoV-2 Omicron variant

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