Immune System News and Research

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MGH researchers find how metformin drug prevents progression of pancreatic cancer

Massachusetts General Hospital investigators may have uncovered a novel mechanism behind the ability of the diabetes drug metformin to inhibit the progression of pancreatic cancer.

17 Jan 2016

Large-scale clinical trial to evaluate dengue vaccine launched in Brazil

A large-scale clinical trial to evaluate whether a candidate vaccine can prevent the mosquito-borne illness dengue fever has been launched in Brazil. The vaccine, TV003, was developed by scientists in the laboratory of Stephen Whitehead, Ph.D., at NIH's National Institute of Allergy and Infectious Diseases (NIAID).

17 Jan 2016

IQWiG finds no added benefit for pomalidomide drug in multiple myeloma

Pomalidomide (trade name: Imnovid) has been approved since 2013 for the treatment of multiple myeloma that has returned and is difficult to treat. The drug is an option for adults who have received two or more prior treatment regimens, including treatment with the drugs lenalidomide and bortezomib, and in whom the last treatment had no sufficient effect.

13 Jan 2016

UHN's multi-disciplinary team successfully completes Canada's first transplant of the upper limb

In a Canadian first, a multi-disciplinary team, led by Dr. Steven McCabe, has successfully completed the country's first transplant of the upper limb.

13 Jan 2016

Pulmonary neuroendocrine cells act like sensor to orchestrate immune response

An uncommon and little-studied type of cell in the lungs has been found to act like a sensor, linking the pulmonary and central nervous systems to regulate immune response in reaction to environmental cues.

13 Jan 2016

Selenium supplementation may have positive and negative effects on immune system

A more thorough evaluation of selenium supplementation is needed, to better understand its benefits to our immune system, and the risks.

13 Jan 2016

CPMC study discovers six genes that affect sleep duration

The Coriell Personalized Medicine Collaborative, a research initiative exploring the utility of genetic information in the clinical setting, has published a study and identified six noteworthy genes that affect human sleep duration.

13 Jan 2016

Pre-existing nutritional deficits, immune dysfunction may increase hepatitis E risk during pregnancy

Researchers from the Johns Hopkins Bloomberg School of Public Health have found a link between pre-existing nutritional deficits and immune dysfunction and the risk of hepatitis E infection during pregnancy.

12 Jan 2016

Malaysian scientists join forces with Harvard experts to help revolutionize lung disease treatment

Malaysian scientists are joining forces with Harvard University experts to help revolutionize the treatment of lung diseases -- the delivery of nanomedicine deep into places otherwise impossible to reach.

12 Jan 2016

Increasing levels of FGF21 hormone protects against loss of immune function in the elderly

A hormone that extends lifespan in mice by 40% is produced by specialized cells in the thymus gland, according to a new study by Yale School of Medicine researchers. The team also found that increasing the levels of this hormone, called FGF21, protects against the loss of immune function that comes with age.

12 Jan 2016

New article suggests that playing American football may contribute to hypertension

As National Football League playoff games are underway, a new article published in the "Hypotheses" section of the January 2016 issue of The FASEB Journal, suggests that the toll the sport takes on players' bodies extends beyond head trauma and damage to limbs and joints. The trauma and damage associated with football participation may also be linked to elevations in blood pressure through immune system activation and inflammation.

12 Jan 2016

Common painkiller diclofenac has significant anti-cancer properties

Diclofenac, a common painkiller, has significant anti-cancer properties, according to researchers from the Repurposing Drugs in Oncology project.

12 Jan 2016

Researchers take major step towards developing vaccine for river blindness

The world's first vaccine for a disease that causes misery for millions in Africa could be tested within five years.

12 Jan 2016

Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

The most frequent fungal threat to humans, Candida albicans, is a common cause oral and genital infection. The fungal infections are often worsened by overwhelming inflammatory responses in the body and cause high mortality among risk groups. Umeå University doctoral student Ava Hosseinzadeh has discovered two novel anti-inflammatory agents, an antioxidant and an anti-inflammatory molecule, which could be used to control the hyper-inflammatory responses to the fungal infection.

12 Jan 2016

Excess folic acid intake causes lowered immune function in aged mice

Previous studies have shown an association between high folic acid intake and a reduction in the immune system defenses needed to fight viral infections and cancer. In a new study in mice published in the Journal of Nutritional Biochemistry, scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University set out to determine if excess folic acid intake caused adverse changes in the immune system.

12 Jan 2016

MD Anderson signs collaborative research and development agreement with Enumeral

The University of Texas MD Anderson Cancer Center today announced that it has entered into a collaborative research and development agreement with Enumeral Biomedical Holdings Inc.

12 Jan 2016

Blocking brain inflammation could protect against memory, behaviour changes

A University of Southampton-led study has found that blocking a receptor in the brain responsible for regulating immune cells could protect against the memory and behaviour changes seen in the progression of Alzheimer's disease.

11 Jan 2016

F-star signs agreement with AbbVie to discover, develop bispecific antibodies in immuno-oncology

F-star today announced that it has entered into a collaboration and license agreement with AbbVie to research and develop bispecific antibodies in immuno-oncology. Financial terms were not disclosed.

11 Jan 2016

UA researchers find genetic mutations associated with respiratory disease

Asthma affects more than 278 million people worldwide and can lead to serious consequences later in life. While current approved therapies address symptoms, they do not halt disease progression.

11 Jan 2016

UVA's brain discovery hailed as one of 2015's biggest scientific breakthroughs

A shocking discovery about the human brain made at the University of Virginia School of Medicine is being hailed as one of 2015's biggest scientific breakthroughs by numerous year-end lists, including those compiled by Scientific American, Science, The Huffington Post and the National Institutes of Health.

11 Jan 2016

Immune System News and Research

MGH researchers find how metformin drug prevents progression of pancreatic cancer

Large-scale clinical trial to evaluate dengue vaccine launched in Brazil

IQWiG finds no added benefit for pomalidomide drug in multiple myeloma

UHN's multi-disciplinary team successfully completes Canada's first transplant of the upper limb

Pulmonary neuroendocrine cells act like sensor to orchestrate immune response

Selenium supplementation may have positive and negative effects on immune system

CPMC study discovers six genes that affect sleep duration

Pre-existing nutritional deficits, immune dysfunction may increase hepatitis E risk during pregnancy

Malaysian scientists join forces with Harvard experts to help revolutionize lung disease treatment

Increasing levels of FGF21 hormone protects against loss of immune function in the elderly

New article suggests that playing American football may contribute to hypertension

Common painkiller diclofenac has significant anti-cancer properties

Researchers take major step towards developing vaccine for river blindness

Novel anti-inflammatory agents could control hyper-inflammatory responses to fungal infection

Excess folic acid intake causes lowered immune function in aged mice

MD Anderson signs collaborative research and development agreement with Enumeral

Blocking brain inflammation could protect against memory, behaviour changes

F-star signs agreement with AbbVie to discover, develop bispecific antibodies in immuno-oncology

UA researchers find genetic mutations associated with respiratory disease

UVA's brain discovery hailed as one of 2015's biggest scientific breakthroughs

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