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New model predicts which COVID-19 patients are at higher risk for hospitalization

Cleveland Clinic researchers have developed and validated a risk prediction model (called a nomogram) that can help physicians predict which patients who have recently tested positive for SARS-CoV-2, the virus that causes COVID-19, are at greatest risk for hospitalization.

12 Aug 2020

Research looks at convalescent plasma use in COVID-19 mouse model

A new study by researchers at the University of Iowa and published on the preprint server bioRxiv in August 2020 reports the utility of a mouse model that recapitulates several aspects of human COVID-19 and can reflect the antiviral efficacy of new drugs as well.

12 Aug 2020

Study identifies three potential drugs to eradicate parasitic worms

Scientists have revealed a way to eradicate parasitic worms by stopping them from using alternative metabolism pathways provided by bacteria that live within them, according to new findings published today in eLife.

12 Aug 2020

SARS-CoV-2 a "swarm" of mutant viruses

In this new study, the virus was serially passaged in independent cell types in a controlled environment. The researchers found that the virus rapidly adapts to the changing conditions in culture by selecting for pre-existing species.

12 Aug 2020

COMBAT study shows how pancreatic cancer patients can benefit from immunotherapy

Working with an international team of researchers, HonorHealth Research Institute and the Translational Genomics Research Institute, an affiliate of City of Hope, were instrumental in one of the first clinical trials showing how pancreatic cancer patients can benefit from immunotherapy, according to a four-year study published in a premier scientific journal, Nature Medicine.

11 Aug 2020

Mouse study shows potential new way to unlock the power of immunotherapy for cancer patients

Immunotherapy has revolutionized cancer treatment by stimulating the patient's own immune system to attack cancer cells, yielding remarkably quick and complete remission in some cases. But such drugs work for less than a quarter of patients because tumors are notoriously adept at evading immune assault.

11 Aug 2020

Scientist explains why COVID-19 targets only some organs while others are spared

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the enzyme angiotensin-converting enzyme 2 (ACE2) to enter and infect human cells. It causes COVID-19 and can lead to a multitude of complications, including multi-organ impairment, partially due to the abundant expression of ACE2 in all human tissues.

11 Aug 2020

Focusing on human enzymes and not SARS-CoV-2 could help treat COVID-19

Now, breakthrough research into malaria suggests targeting enzymes from the human host, rather than from the pathogen itself. The new research could pave the way for effective treatments for a wide range of infectious diseases, including the coronavirus disease (COVID-19).

11 Aug 2020

Inhaled delivery of a potent neutralizing nanobody effective against SARS-CoV-2

A recent study by researchers from China, available on the bioRxiv preprint server, shows how stable neutralizing nanobody Nb11-59 might be a promising prophylactic and therapeutic molecule against coronavirus disease (COVID-19) – especially if administered via the inhalatory route.

11 Aug 2020

First clinical trial could become an effective way to deliver chemotherapy to abdominal cancer patients

City of Hope surgical researchers are the first in the nation to open a clinical trial that could one day become an effective way to deliver chemotherapy to abdominal cancer patients who currently have very few treatment options.

11 Aug 2020

Using medieval medicine to find new treatments for modern-day infections

News-Medical spoke to researchers from the University of Warwick about their research investigating natural antimicrobials and their potential as antibiotics.

11 Aug 2020

Opioid risk is higher for patients transitioning to skilled nursing facilities

Hospital patients discharged to skilled nursing facilities often bring a high-dose painkiller prescription with them, suggesting more attention should be paid to opioid safety for those patients, research from the Oregon State University College of Pharmacy shows.

11 Aug 2020

New research on COVID-19 and aging

A new study published on the preprint server medRxiv in August 2020 shows that genetic factors, chronic disease, and biological aging define the relationship between aging and the severity of COVID-19.

11 Aug 2020

Specific HIV and tuberculosis medications decrease risk of death in adults with drug-resistant TB

After looking at the health records of over 10,000 patients with both HIV and multidrug resistant Tuberculosis (TB) in over 20 different countries, researchers at the Perelman School of Medicine at the University of Pennsylvania in collaboration with the Centers for Disease Control and Prevention, McGill University, and other institutions around the world, found that implementing antiretroviral therapy (ART) for HIV and newer tuberculosis medications decreased the risk of death for adults with drug-resistant TB.

11 Aug 2020

Drugs News and Research

New model predicts which COVID-19 patients are at higher risk for hospitalization

Research looks at convalescent plasma use in COVID-19 mouse model

Study identifies three potential drugs to eradicate parasitic worms

SARS-CoV-2 a "swarm" of mutant viruses

COMBAT study shows how pancreatic cancer patients can benefit from immunotherapy

Mouse study shows potential new way to unlock the power of immunotherapy for cancer patients

Scientist explains why COVID-19 targets only some organs while others are spared

Focusing on human enzymes and not SARS-CoV-2 could help treat COVID-19

Inhaled delivery of a potent neutralizing nanobody effective against SARS-CoV-2

First clinical trial could become an effective way to deliver chemotherapy to abdominal cancer patients

Using medieval medicine to find new treatments for modern-day infections

Opioid risk is higher for patients transitioning to skilled nursing facilities

New research on COVID-19 and aging

Specific HIV and tuberculosis medications decrease risk of death in adults with drug-resistant TB

Researchers discover dose threshold that improves delivery of cancer-fighting drugs into a tumor

Rice engineers use gene editing to facilitate drug discovery based on natural fungus

Additional $400,000 awarded for research projects focused on cardiovascular impact of COVID-19

Researchers identify new treatment for osteoarthritis

TAU researchers reduce colorectal cancer metastases after tumor removal surgery

Study suggests novel strategy to slow down evolution of antibiotic resistance

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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