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CTCA at Western announces launch of Phase II NivoPlus clinical trial

Cancer Treatment Centers of America at Western Regional Medical Center in Goodyear, Arizona, has announced the launch of Phase II of the NivoPlus clinical trial, which combines the immunotherapeutic agent nivolumab with chemotherapy drugs irinotecan and capecitabine.

11 Jan 2016

Salk Institute scientists find new target for glioblastoma multiforme treatment

Glioblastoma multiforme is a particularly deadly cancer. A person diagnosed with this type of brain tumor typically survives 15 months, if given the best care. The late Senator Ted Kennedy succumbed to this disease in just over a year.

11 Jan 2016

Virginia Tech scientists find potential way to influence memory formation in the immune system

Scientists at the Virginia Tech Carilion Research Institute have found a potential way to influence long-term memory formation in the immune system. The researchers published their results today in Nature Communications.

11 Jan 2016

New project aims to develop CAR-T cell immuno-oncology cellular therapy for solid tumours

The Cell Therapy Catapult, the UK organisation dedicated to the growth of the UK cell and gene therapy industry by bridging the gap between scientific research and commercialisation, the University of Birmingham and Cancer Research Technology, the commercialisation arm of Cancer Research UK, announces today the launch of a collaboration to develop a new immuno-oncology cellular therapy based on gene modifying T cells to target solid tumours.

8 Jan 2016

Elsevier's new open access journal features novel method to make cancer clinical trials more effective

The first issue of Elsevier's new open access journal Contemporary Clinical Trials Communications features a new method to make cancer clinical trials more effective, a better way of determining whether a trial was successful and a dashboard that helps patients enroll in trials.

7 Jan 2016

DNA damage may lead to mutation and changes in cell

A team of researchers from Colorado State University has been studying DNA damage in living cells to learn more about how genetic abnormalities arise. It has long been known that DNA molecules in every cell get constantly damaged by things from the outside environment, like sunlight, cigarette smoke and radiation. However, more recently researchers have discovered that sources from within the cell itself can sometimes be even more damaging.

7 Jan 2016

Scientists find genetic link to unexplained heart failure affecting pregnant women

Scientists have found that women who suffer unexplained heart failure towards the end of pregnancy or shortly after giving birth share certain genetic changes.

7 Jan 2016

Drexel biomedical engineer identifies immune cell as potential strategy for growing blood vessels

In what could be a pivotal step toward repairing non-healing wounds and damaged organs, a Drexel University biomedical engineer has identified an immune cell as a potential strategy for growing blood vessels.

7 Jan 2016

Insulin-producing cells' mitochondria may represent useful therapeutic target in type 2 diabetes

Factors in the blood from calorie-restricted rats can modify energy-producing mitochondria within the insulin-producing cells that regulate blood sugar levels, new research shows. This has a positive impact on glucose-stimulated insulin secretion and protects cells from fatty acid and glucose toxicity.

7 Jan 2016

Toxins in staphylococcus bacteria can help cancer cells gain control over healthy cells

Our skin is covered in millions of bacteria and most of them help keep us healthy. However, for patients with lymphoma, it may be a rather different story, as new research from the University of Copenhagen shows that toxins in the staphylococcus bacteria help cancer cells gain control over healthy cells.

6 Jan 2016

New allocation system boosts kidney transplantation rates for black and Hispanic patients on waiting lists

Year-old changes to the system that distributes deceased donor kidneys nationwide have significantly boosted transplantation rates for black and Hispanic patients on waiting lists, reducing racial disparities inherent in the previous allocation formula used for decades, according to results of research led by a Johns Hopkins transplant surgeon.

6 Jan 2016

Study shows clear role of bacteria in modulating immune function in the lungs

Microbiota--the trillions of bacteria that co-exist in the body--regulate the ability of lung dendritic cells to generate immune responses, according to a study led by researchers from the Icahn School of Medicine at Mount Sinai, published online in the Journal of Experimental Medicine.

6 Jan 2016

Scientists demonstrate workings of CCL2 mechanism that stimulates nerve regeneration

The peripheral nervous system is a vast network of nerves that exists primarily outside of brain and spinal cord and connects to the far reaches of the body. The very expanse of peripheral nerves makes them highly vulnerable to injuries such as blunt-force blows, cuts, and leg and arm fractures, as well as diseases that attack peripheral nerves such as diabetes, Charcot-Marie-Tooth, and Guillain-Barre syndrome.

6 Jan 2016

SillaJen reports initiation of multinational randomized Phase 3 study of Pexa-Vec in HCC patients

SillaJen, Inc., a private, clinical-stage, biotherapeutics company focused on the development of oncolytic immunotherapy products for cancer, has announced the initiation of a multinational randomized Phase 3 open-label study of its lead product candidate, Pexa-Vec (formerly JX-594), in patients with advanced liver cancer, also known as hepatocellular carcinoma (HCC).

5 Jan 2016

Scripps biologist describes major advancement in flu vaccine research

Every fall, millions of people roll up their sleeves to get a flu shot. Up to 20 percent of the population gets the flu and more than 200,000 people are hospitalized with flu complications each year, according to the U.S. Centers for Disease Control and Prevention. While seasonal vaccines provide some protection, they are not always effective because the strains of influenza virus in the vaccine may not be well matched to the flu viruses circulating that year. So researchers are searching for a way to develop a more universal vaccine that would be effective against any variety of influenza.

5 Jan 2016

Study reveals promising mechanism for attacking Ebola virus

In late December, nearly two years after the epidemic began, the World Health Organization has declared the African country of Guinea to be free of Ebola virus infections. But, the race to find a cure and therapies to combat the disease are forging ahead as officials warn that inattention could lead to another epidemic.

5 Jan 2016

Using stem cells to tackle CNS disorders: an interview with Dr Stefano Pluchino

My laboratory’s long standing interest is the study of the signaling capabilities of stem cells, both under homeostatic conditions

From Beckman Coulter Life Sciences - Flow Cytometry 5 Jan 2016

Nottingham researchers explore viruses that can destroy food poisoning bugs in the gut

Viruses that can seek and destroy food poisoning bugs in the gut are being investigated by researchers at The University of Nottingham, thanks to a prestigious new grant.

5 Jan 2016

Researchers to undertake long-term clinical trial of artificial pancreas system for type 1 diabetes patients

Researchers will soon undertake one of the largest-ever long-term clinical trials of a system designed to help regulate blood sugar levels of individuals with type 1 diabetes mellitus. If the so-called artificial pancreas system performs in patients as hoped, it could lead to commercial trials and eventual regulatory approval in the United States and abroad.

5 Jan 2016

UT Southwestern scientists use new gene-editing technique to prevent progression of DMD in young mice

Using a new gene-editing technique, a team of scientists from UT Southwestern Medical Center stopped progression of Duchenne muscular dystrophy (DMD) in young mice.

4 Jan 2016

Immune System News and Research

CTCA at Western announces launch of Phase II NivoPlus clinical trial

Salk Institute scientists find new target for glioblastoma multiforme treatment

Virginia Tech scientists find potential way to influence memory formation in the immune system

New project aims to develop CAR-T cell immuno-oncology cellular therapy for solid tumours

Elsevier's new open access journal features novel method to make cancer clinical trials more effective

DNA damage may lead to mutation and changes in cell

Scientists find genetic link to unexplained heart failure affecting pregnant women

Drexel biomedical engineer identifies immune cell as potential strategy for growing blood vessels

Insulin-producing cells' mitochondria may represent useful therapeutic target in type 2 diabetes

Toxins in staphylococcus bacteria can help cancer cells gain control over healthy cells

New allocation system boosts kidney transplantation rates for black and Hispanic patients on waiting lists

Study shows clear role of bacteria in modulating immune function in the lungs

Scientists demonstrate workings of CCL2 mechanism that stimulates nerve regeneration

SillaJen reports initiation of multinational randomized Phase 3 study of Pexa-Vec in HCC patients

Scripps biologist describes major advancement in flu vaccine research

Study reveals promising mechanism for attacking Ebola virus

Using stem cells to tackle CNS disorders: an interview with Dr Stefano Pluchino

Nottingham researchers explore viruses that can destroy food poisoning bugs in the gut

Researchers to undertake long-term clinical trial of artificial pancreas system for type 1 diabetes patients

UT Southwestern scientists use new gene-editing technique to prevent progression of DMD in young mice

Understanding the DNA Damage Response in Innate Immunity eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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