Adenosine News and Research

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Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a ß-N9-glycosidic bond.

Study uncovers how inflammation in brain blood vessels exacerbates damage in vascular dementia

A new study from UCLA Health has uncovered how inflammation in brain blood vessels exacerbates damage in vascular dementia and demonstrated that targeting this process with a repurposed drug can promote brain repair and functional recovery in mice.

1 Jul 2025

Targeting mitochondrial dynamics to combat breast cancer metastasis

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a leading cause of cancer-related mortality due to its aggressive nature and limited therapeutic targets.

27 Jun 2025

Experimental drug promotes weight loss by heating fat instead of suppressing appetite

An article published in the journal Nature Metabolism presents an experimental drug that stimulates adipose tissue cells to produce heat through a process known as thermogenesis, thereby promoting weight loss.

24 Jun 2025

Could a diabetes drug be the key to stopping Alzheimer’s?

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, linking diabetes and neurodegeneration.

17 Jun 2025

Understanding the role of astrocytes in depression and neuroinflammation

Major depressive disorder (MDD) is a mental health condition that negatively affects the mood of a person and causes a loss of interest in activities that were previously associated with happiness.

13 Jun 2025

Inhibiting cancer cells' energy source with natural acid ester

Looking to nature for answers to complex questions can reveal new and unprecedented results that can even affect cells on molecular levels.

10 Jun 2025

What happens to your body and mind during a five-day water fast?

A five-day water-only fast led to significant weight, fat, and lean muscle loss in middle-aged women, along with improved mood and marked changes in metabolic and inflammatory markers. The study also found that psychological traits like emotional intelligence and impulsivity influenced the amount of fat and muscle lost during fasting.

9 Jun 2025

Energy drain from antibiotics spurs bacteria to resist treatment faster

Antibiotics are supposed to wipe out bacteria, yet the drugs can sometimes hand microbes an unexpected advantage.

9 Jun 2025

Understanding how base editing tools work at the molecular level

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized treatment that repaired his specific genetic mutation.

4 Jun 2025

Breakthrough study finds genes behind calcium pyrophosphate deposition disease

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent.

28 May 2025

Study sheds new light on how caffeine can impair sleep and memory recovery

Caffeine is not only found in coffee, but also in tea, chocolate, energy drinks and many soft drinks, making it one of the most widely consumed psychoactive substances in the world.

28 May 2025

Advancing GPCR drug discovery with fragment screening using GCI technology

Evotec's insights into GPCRs and waveRAPID technology reveal new opportunities in drug discovery, focusing on orphan receptors and innovative screening methods.

From Creoptix (A Malvern Panalytical brand) 23 May 2025

Cysteine depletion triggers rapid weight loss in mice

Mice genetically engineered to lack the ability to make the amino acid cysteine, and fed a cysteine-free diet, lost 30 percent of their body weight in just one week, a new study shows.

22 May 2025

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates UMN-120 and UMN-121 showed superior efficacy to current treatments in mouse models and retained potency against M. tuberculosis.

5 May 2025

RNA editing enzyme found to trigger neuroinflammation in Parkinson's

Parkinson's disease (PD) is a neurodegenerative disorder in which the α-synuclein protein abnormally aggregates within brain cells, causing neuronal damage.

3 May 2025

Caffeine increases brain complexity during sleep and shifts it toward a critical state

Caffeine shifts brain activity during sleep by increasing EEG complexity and reducing long-range temporal correlations, particularly in non-REM (NREM) sleep. These changes reflect a movement toward a “critical regime” of neural processing, more pronounced in younger adults.

1 May 2025

High fructose diets impair brain function and appetite control, study shows

Review highlights how excessive fructose intake disrupts brain energy balance, appetite regulation, and cognitive function. Processed sources, such as sugary drinks, may overwhelm metabolic pathways and induce neuroinflammation, particularly during adolescence.

30 Apr 2025

Curcumin shows promise for treating obesity, inflammation, and neurodegenerative diseases

Researchers explore the medicinal role of curcumin in the treatment and prevention of neuroinflammation and metabolic disorders.

30 Apr 2025

Proteins linked to Parkinson's and ALS found to protect mitochondria

Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as "guardians" of mitochondria, small organelles, or subunits, within a cell that make and store energy and are found in almost all plants and animals.

8 Apr 2025