Adenosine News and Research

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Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a ß-N9-glycosidic bond.

Advancing GPCR drug discovery with fragment screening using GCI technology

Evotec's insights into GPCRs and waveRAPID technology reveal new opportunities in drug discovery, focusing on orphan receptors and innovative screening methods.

From Creoptix (A Malvern Panalytical brand) 23 May 2025

Cysteine depletion triggers rapid weight loss in mice

Mice genetically engineered to lack the ability to make the amino acid cysteine, and fed a cysteine-free diet, lost 30 percent of their body weight in just one week, a new study shows.

22 May 2025

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

Researchers have developed next-generation rifamycin analogs that effectively kill both replicating and nonreplicating Mycobacterium abscessus while minimizing drug-drug interactions. Lead candidates UMN-120 and UMN-121 showed superior efficacy to current treatments in mouse models and retained potency against M. tuberculosis.

5 May 2025

RNA editing enzyme found to trigger neuroinflammation in Parkinson's

Parkinson's disease (PD) is a neurodegenerative disorder in which the α-synuclein protein abnormally aggregates within brain cells, causing neuronal damage.

3 May 2025

Caffeine increases brain complexity during sleep and shifts it toward a critical state

Caffeine shifts brain activity during sleep by increasing EEG complexity and reducing long-range temporal correlations, particularly in non-REM (NREM) sleep. These changes reflect a movement toward a “critical regime” of neural processing, more pronounced in younger adults.

1 May 2025

High fructose diets impair brain function and appetite control, study shows

Review highlights how excessive fructose intake disrupts brain energy balance, appetite regulation, and cognitive function. Processed sources, such as sugary drinks, may overwhelm metabolic pathways and induce neuroinflammation, particularly during adolescence.

30 Apr 2025

Curcumin shows promise for treating obesity, inflammation, and neurodegenerative diseases

Researchers explore the medicinal role of curcumin in the treatment and prevention of neuroinflammation and metabolic disorders.

30 Apr 2025

Proteins linked to Parkinson's and ALS found to protect mitochondria

Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as "guardians" of mitochondria, small organelles, or subunits, within a cell that make and store energy and are found in almost all plants and animals.

8 Apr 2025

High-fat diet fuels cancer spread via rogue platelets

Researchers explore the role of a high-fat diet in promoting the formation of premetastatic niches and platelet activation.

7 Apr 2025

Study links neurotensin deficiency to ovulatory dysfunction in PCOS

Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations.

3 Apr 2025

Traditional Chinese medicine targets cholesterol metabolism for cancer treatment

Researchers explore how natural compounds in traditional Chinese medicine can modulate cholesterol metabolism to combat cancer.

31 Mar 2025

How HIIT and intermittent fasting alter metabolism in postmenopausal women

How the combination of HIIT with intermittent fasting or a low-calorie diet improves metabolic health among postmenopausal women.

28 Mar 2025

Breakthrough study unveils mechanics of DNA unwinding

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life.

19 Mar 2025

New insights into ADAR1 mechanisms could revolutionize autoimmune and cancer therapies

A research team led by Rice University's Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a protein that regulates ribonucleic acid (RNA) induced immune responses.

17 Mar 2025

Advances in organ preservation techniques and future prospects

A review article published in Engineering delves into the crucial field of organ preservation, exploring its history, current techniques, and future prospects.

14 Mar 2025

Scientists uncover structure of key enzyme to block cancer cell energy supply

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal cells maintain a balance of energy.

6 Mar 2025