Cytochrome P450 News and Research

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Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy. It has also been shown to be effective for the treatment of mood disorders and migraine headaches.

17 Feb 2014

Johns Hopkins researchers discover epilepsy drug reduces obesity-related blood sugar levels

Johns Hopkins researchers have discovered that valproic acid, a widely prescribed drug for treating epilepsy, has the additional benefits of reducing fat accumulation in the liver and lowering blood sugar levels in the blood of obese mice.

30 Jan 2014

Research shows smoking and obesity together may pose triple health threat

Millions of people who are obese and smoke tobacco may face additional health problems — including their responses to common prescription medicines — that extend beyond the well-known links with cancer, heart attacks and stroke, according to a report presented here today.

12 Sep 2013

Discovery highlights protective role of liver enzyme in treating jaundice

Helping to protect newborns and older patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown how a liver enzyme protects cells from damage caused by the condition.

10 Jun 2013

Pharmacological study shows interactions between drugs can be detected with minute doses

Clinical pharmacologists at Heidelberg University Hospital have achieved major progress for improving the reliability of drugs. In a pharmacological study, they showed for the first time that interactions between drugs can be detected with minute doses in the range of nanograms.

15 Apr 2013

CYP1B1 protein prevents head and neck cancers, say researchers

Head and neck cancers typically begin in squamous cells that line moist surfaces inside the mouth, nose and throat. Squamous cell carcinoma of the head and neck (HNSCC) is the sixth most common type of cancer in the United States, and it is sometimes preceded by the appearance of changes inside the oral cavity called precancerous lesions.

10 Apr 2013

Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Armetheon, Inc., a clinical stage biopharmaceutical company, announced today that it plans to develop its novel oral anti-coagulant (OAC), tecarfarin (ATI-5923), for a patient population which includes those who have prosthetic heart valves or chronic renal dysfunction.

11 Mar 2013

Gene variant boosts ulcer susceptibility in NSAID users

A single nucleotide polymorphism in the cytochrome P450 2C gene cluster influences the risk for peptic ulcer disease in people taking non-steroidal anti-inflammatory drugs, a study reveals.

31 Jan 2013

Gastrointestinal, liver effects common after doxycycline in cats

Doxycycline, an antibiotic derivative of tetracycline, commonly results in adverse gastrointestinal side effects and increased liver enzyme activity in cats, report German researchers.

25 Jan 2013

CYP2J2 implicated in preeclampsia

Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression contributes to preeclampsia.

11 Dec 2012

Risk factors revealed for anti-tuberculosis drug hepatotoxicity

The risk for hepatotoxicity among patients treated with anti-tuberculosis drugs is affected by gender, ethnicity, and the presence of genetic polymorphisms, say Argentinean researchers.

10 Dec 2012

CYP2J2 implicated in preeclampsia

Study findings suggest that uteroplacental cytochrome P450 subfamily 2J polypeptide 2 overexpression contributes to preeclampsia.

10 Dec 2012

Physicians beware of fruity drug interactions

An understanding of the potential for pharmacokinetic interaction between orally administered drugs and grapefruit is necessary in view of an increase in marketed medications that fit the risk criteria, suggest Canadian researchers.

30 Nov 2012

New FDA guidelines on HIV And TB drug doses may not apply to African and Asian patients

In January, 2012, the U.S. Food and Drug Administration (FDA) issued new guidelines on dosing of an HIV medication used to treat people infected with both HIV and tuberculosis (TB) because of a potential interaction between two of the main drugs used to treat each disease.

24 Jul 2012

Rapid test to identify patients not responding to painkiller tramadol

French researchers have found a way to identify quickly the 5-10% of patients in whom the commonly used painkiller, tramadol, does not work effectively. A simple blood test can produce a result within a few hours, enabling doctors to switch a non-responding patient on to another painkiller, such as morphine, which will be able to work in these patients.

11 Jun 2012

Simple blood test can quickly identify 'poor metabolisers'

11 Jun 2012

NJIT professor receives $340,000 NIH grant to investigate membrane proteins

NJIT Associate Professor Edgardo Farinas has been awarded today a three-year $340,000 National Institutes of Health (NIH) grant to investigate spores as a protein display platform for the directed evolution of membrane proteins.

3 May 2012

CYP1B1 protein may be a potential target for intervention in head and neck cancer

Squamous cell carcinoma of the head and neck-which typically arises from thin, flat cells that line moist surfaces inside the mouth, nose and throat-is the sixth most common type of cancer worldwide, and it has a relatively low five-year survival rate and a high recurrence rate.

2 Apr 2012

Nuvilex discusses Cell-in-a-Box technology used for pancreatic cancer clinical trial

Nuvilex, Inc., an emerging biotechnology provider of cell and gene therapy solutions, discussed today the proprietary Cell-in-a-Box technology, being acquired from SG Austria, that was used for the pancreatic cancer clinical trial and may have an effect on downstream micro metastatic disease.

14 Mar 2012

Study may help personalize pain medication management for sickle cell disease patients

A study that may help personalize pain medication management for sickle cell disease patients is underway at Georgia Health Sciences University.

9 Dec 2011

Cytochrome P450 News and Research

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Johns Hopkins researchers discover epilepsy drug reduces obesity-related blood sugar levels

Research shows smoking and obesity together may pose triple health threat

Discovery highlights protective role of liver enzyme in treating jaundice

Pharmacological study shows interactions between drugs can be detected with minute doses

CYP1B1 protein prevents head and neck cancers, say researchers

Armetheon plans to develop tecarfarin against prosthetic heart valves or chronic renal dysfunction

Gene variant boosts ulcer susceptibility in NSAID users

Gastrointestinal, liver effects common after doxycycline in cats

CYP2J2 implicated in preeclampsia

Risk factors revealed for anti-tuberculosis drug hepatotoxicity

CYP2J2 implicated in preeclampsia

Physicians beware of fruity drug interactions

New FDA guidelines on HIV And TB drug doses may not apply to African and Asian patients

Rapid test to identify patients not responding to painkiller tramadol

Simple blood test can quickly identify 'poor metabolisers'

NJIT professor receives $340,000 NIH grant to investigate membrane proteins

CYP1B1 protein may be a potential target for intervention in head and neck cancer

Nuvilex discusses Cell-in-a-Box technology used for pancreatic cancer clinical trial

Study may help personalize pain medication management for sickle cell disease patients

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