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Smell loss emerges as the early behavioural sign of Alzheimer’s

Research reveals immune cells target brainstem nerves, linking smell loss to early Alzheimer's, offering potential for earlier diagnosis and intervention.

4 Sep 2025

Genetic variant disrupts brain’s cleanup crew increasing Alzheimer’s risk

A Nature study published today and led by researchers at the University of South Florida's USF Health Byrd Alzheimer's Institute pinpoints how a genetic variant disrupts microglia - the brain's "cleanup crew" - increasing the risk of Alzheimer's disease.

3 Sep 2025

Epigenomic erosion linked to cognitive decline in Alzheimer’s patients

Most people recognize Alzheimer's from its devastating symptoms such as memory loss, while new drugs target pathological aspects of disease manifestations, such as plaques of amyloid proteins.

2 Sep 2025

Why metformin could protect the brain by rewiring mitochondria

Metformin boosts human oligodendrocyte differentiation and myelination across stem-cell, organoid, and chimera models. The study links these effects to mitochondrial metabolic shifts, supporting its potential as a therapy for multiple sclerosis.

1 Sep 2025

How plant compounds could target Alzheimer’s disease from multiple angles

This review highlights how dietary polyphenols modulate Alzheimer’s disease biology through antioxidant, anti-inflammatory, and multi-target mechanisms, supported by in-silico docking analyses. Despite promise, challenges in bioavailability and brain delivery remain key hurdles to clinical translation.

31 Aug 2025

Research sheds new light on depression’s biological roots

Researchers at McGill University and the Douglas Institute have identified two specific types of brain cells that are altered in people with depression.

28 Aug 2025

Unlocking neuroglia’s potential to halt neurodegeneration and restore brain homeostasis

In a revealing Genomic Press Interview published today in Brain Medicine, Professor Alexei Verkhratsky dismantles decades of neuroscience orthodoxy with discoveries that position neuroglia as active architects of brain function rather than passive cellular bystanders.

26 Aug 2025

High-salt diet linked to brain inflammation that raises blood pressure

A new study finds that a high-salt diet triggers brain inflammation that drives up blood pressure.

21 Aug 2025

Cats with dementia show brain changes similar to Alzheimer’s in humans

Cats with dementia have brain changes similar to those of people with Alzheimer's disease, offering a valuable model for studying the condition in humans, a study says.

12 Aug 2025

Special von Economo neurons may hold key to super-sharp memory in 80+ superagers

Researchers at Northwestern University’s SuperAging Program reveal how some people over 80 retain memory performance like those decades younger, linking it to unique brain structures, reduced pathology, and lower inflammation. Their 25-year study highlights genetic, cellular, and social traits that may protect cognitive function.

10 Aug 2025

Lithium deficiency emerges as a hidden driver of Alzheimer’s

What is the earliest spark that ignites the memory-robbing march of Alzheimer’s disease? Why do some people with Alzheimer’s-like changes in the brain never go on to develop dementia? These questions have bedeviled neuroscientists for decades.

8 Aug 2025

Cedars-Sinai study finds new way to combat Alzheimer’s in preclinical models

In a preclinical study, Cedars-Sinai investigators found that boosting angiotensin converting enzyme (ACE) in key immune cells called microglia in the brain helped protect the brains of specially bred laboratory mice against Alzheimer's disease.

6 Aug 2025

Targeted microglia replacement shows promise against fatal neurodegenerative conditions

Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within the first years of life.

6 Aug 2025

UCSF discovery points to new strategies for Alzheimer's treatment

UCSF scientists have discovered how microglia engulf and break down amyloid beta, a protein that builds up in Alzheimer's, with devastating consequences for the brain.

28 Jul 2025

Dual cancer drugs restore memory and rewire brain cells in Alzheimer’s mouse models

Researchers identified a combination of two existing cancer drugs, letrozole and irinotecan, that reversed Alzheimer’s disease-related changes in brain cell networks and improved memory in mouse models. The study supports a multi-cell-type, network-correcting strategy as a promising path for future Alzheimer’s treatments.

22 Jul 2025

Overuse injuries spark lasting pain and mood changes through inflammation, rat study finds

Repetitive reaching tasks in mature female rats triggered persistent pain-like and sickness behaviors linked to a surge in IL-6-driven inflammation throughout muscles, blood, and the brain. These findings reveal how overuse injuries provoke both physical and mood-related symptoms through a neuroimmune cascade.

20 Jul 2025

Research suggests a new strategy to improve blood flow to the brain to battle Alzheimer's

New University of Virginia School of Medicine research suggests an unexpected way doctors may be able to improve blood flow to the brain to battle Alzheimer's and other neurodegenerative diseases.

16 Jul 2025

Study uncovers how inflammation in brain blood vessels exacerbates damage in vascular dementia

A new study from UCLA Health has uncovered how inflammation in brain blood vessels exacerbates damage in vascular dementia and demonstrated that targeting this process with a repurposed drug can promote brain repair and functional recovery in mice.

1 Jul 2025

Shingles and RSV vaccines with AS01 adjuvant reduce dementia risk

Researchers found that older adults who received AS01-adjuvanted shingles or RSV vaccines had a significantly lower risk of developing dementia within 18 months compared to flu vaccine recipients. The protective effect is likely linked to the AS01 adjuvant itself, highlighting new avenues for dementia prevention.

30 Jun 2025

Can saffron treat Alzheimer’s and depression?

Saffron shows promise as a natural treatment for depression and cognitive decline, performing as well as standard drugs in clinical trials. However, more rigorous studies are needed before saffron can be recommended in mainstream psychiatric and dementia care.

26 Jun 2025