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Cryo-EM reveals structural dynamics of RNAP-DNA interactions during transcription initiation

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription bubble, so that one exposed DNA strand can be copied into a complementary RNA strand.

10 Jul 2024

Efficient multi-site genome editing with retron-derived multitrons

Genome editing has become a widely adopted technology to modify DNA in cells, allowing scientists to study diseases in the lab and develop therapies that repair disease-causing mutations.

10 Jul 2024

Enzyme breakthrough could revolutionize the production of greener cancer treatments

Scientists from The University of Manchester have uncovered a more efficient and sustainable way to make peptide-based medicines, showing promising effectiveness in combating cancers.

10 Jul 2024

Gut microbiome health crucial to survival after solid organ transplants

'Unhealthy' gut microbiome patterns are linked to a heightened risk of death after a solid organ transplant, finds research published online in the journal Gut.

9 Jul 2024

Pentamidine: A promising prophylactic against chlamydial infections

Despite the significant increase in sexually transmitted diseases in recent years, there is currently no vaccine available against common bacterial pathogens such as chlamydia.

9 Jul 2024

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Researchers from Trinity College Dublin have taken a leap forward in understanding how we might fight back against the potentially deadly MRSA bacterium.

9 Jul 2024

Non-invasive saliva test could identify children missing tetanus immunity

University of Birmingham experts are developing a non-invasive saliva test that - within 15 minutes - might identify children across the Global South missing immunity to tetanus who may also have missed out on essential vaccines.

8 Jul 2024

Phages use selfish DNA to outmaneuver competitors

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don't seem to have a role to play in the competition for survival.

5 Jul 2024

Breakthrough humanized mouse model offers new insights for immunotherapy development

A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling.

5 Jul 2024

DNA repair mutations act as a switch for bowel cancer

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

5 Jul 2024

Innovative study on gut bacteria and T cells wins NOSTER & Science Microbiome Prize

In the gut, dozens of strains of bacteria exert different effects on the immune system that in turn impact our health – fending off pathogens, helping digest food and maybe even influencing behavior. But pinpointing which bacteria exert which effects has been challenging.

4 Jul 2024

New study reveals how RNA polymerase opens the transcription bubble in real time

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA.

3 Jul 2024

Mapping pathogen spread and evolution using genomic and human mobility data

A new way to map the spread and evolution of pathogens, and their responses to vaccines and antibiotics, will provide key insights to help predict and prevent future outbreaks.

3 Jul 2024

New research highlights potential of antimicrobial peptide mixtures to inhibit drug resistance

Antibiotics are a cornerstone of modern medicine. They are regularly used to treat bacterial infections or as a prophylactic measure during surgery to prevent infection.

3 Jul 2024

Protein nanocages: A promising frontier in mRNA therapeutics

In recent years, messenger RNA (mRNA) has emerged as a promising avenue for accurate and potent therapeutic interventions. Unlike DNA drugs, mRNA can express genetic information without the risk of integrating into the host genome.

3 Jul 2024

White blood cell type identified as important contributor to inflammation in obesity

Researchers explored neutrophil involvement in visceral adipose tissue (VAT) inflammation in obesity.

3 Jul 2024

Frequent infections and pathobionts boost children's nasal immunity, study reveals

Dynamic interactions with viruses and bacterial pathobionts significantly enhance nasal innate immunity in children, revealing distinct immunophenotypes driven by microbial load and type.

2 Jul 2024

Study reveals refined carbs heighten inflammation and cardiovascular risk

A study in Nutrients journal finds that both the quantity and quality of carbohydrates impact inflammation and cardiovascular disease (CVD) risk. Higher refined carbohydrate intake is linked to greater inflammation and CVD, emphasizing the need for personalized dietary recommendations.

2 Jul 2024

Commercial tattoo and permanent makeup inks can harbor anaerobic bacteria

Researchers have detected anaerobic and aerobic bacteria in commercial tattoo and permanent makeup inks.

2 Jul 2024

Study links common infections to enhanced COVID-19 defense in children

Analyzing nasal swabs taken during the pandemic, researchers at Yale School of Medicine suggest that the frequent presence of other viruses and bacteria may have helped to protect children from the worst effects of COVID-19 by boosting their immune systems.

1 Jul 2024

Bacterial News and Research

Cryo-EM reveals structural dynamics of RNAP-DNA interactions during transcription initiation

Efficient multi-site genome editing with retron-derived multitrons

Enzyme breakthrough could revolutionize the production of greener cancer treatments

Gut microbiome health crucial to survival after solid organ transplants

Pentamidine: A promising prophylactic against chlamydial infections

Trinity College Dublin researchers uncover key to enhancing MRSA vaccine efficacy

Non-invasive saliva test could identify children missing tetanus immunity

Phages use selfish DNA to outmaneuver competitors

Breakthrough humanized mouse model offers new insights for immunotherapy development

DNA repair mutations act as a switch for bowel cancer

Innovative study on gut bacteria and T cells wins NOSTER & Science Microbiome Prize

New study reveals how RNA polymerase opens the transcription bubble in real time

Mapping pathogen spread and evolution using genomic and human mobility data

New research highlights potential of antimicrobial peptide mixtures to inhibit drug resistance

Protein nanocages: A promising frontier in mRNA therapeutics

White blood cell type identified as important contributor to inflammation in obesity

Frequent infections and pathobionts boost children's nasal immunity, study reveals

Study reveals refined carbs heighten inflammation and cardiovascular risk

Commercial tattoo and permanent makeup inks can harbor anaerobic bacteria

Study links common infections to enhanced COVID-19 defense in children

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