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Purifying Proteins from Mammalian Cell Culture

In many cases mammalian cells are the only option to produce recombinant proteins with correct post-translational modifications, e.g. glycosylation, which are required for proper function of the therapeutic protein.

From Sartorius 18 Sep 2018

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

Proteins are essential constituents of cells and their compartments. Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, Germany, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell.

17 Sep 2018

Researchers describe mechanism that sets stage for fate decision of T cells

After a pathogen infects the body, the immune system responds with a remarkable -- and remarkably complicated -- cascade of events.

14 Sep 2018

Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

New work from researchers at Columbia University Vagelos College of Physicians and Surgeons sheds light on how dopamine receptors signal within cells, opening the door for more targeted--and more tolerable--therapeutics to treat an array of neuropsychiatric disorders.

4 Sep 2018

Research team to investigate how blood flow influences formation of plaque

Atherosclerosis - the narrowing of arteries due to plaque buildup - is the underlying reason for the majority of strokes and heart attacks. When atherosclerosis occurs in the arteries that carry blood to the heart muscle, it is called coronary artery disease, the No. 1 killer of Americans.

30 Aug 2018

International research effort yields 'Image-Activated Cell Sorting' technology

Invented over 50 years ago, flow cytometry-based cell sorting has become a widely used tool in biology labs for physically isolating cells based on their global surface marker expression profiles.

28 Aug 2018

'Plastic antibodies' effectively target and eliminate tumor cells

A joint research team from Russia and the U.K. has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs, or "plastic antibodies." NanoMIPs are synthetic polymers that can function as antibodies, selectively binding to target proteins on the surface of cancer cells.

23 Aug 2018

Lowering pH inside tumor cells can slow down spread of cancer

A new study focusing on the environment inside cancer cells may lead to new targeted treatment strategies.

17 Aug 2018

Discovery may help broaden the scope of defenses against HPV

Yale Cancer Center scientists have filled in a key gap in understanding the unusual route by which the Human papillomavirus infects cells.

16 Aug 2018

Real-time dynamic monitoring of cell's nucleus for effective cancer screening

To test for malignancy or monitor the effectiveness of cancer treatment, a person's tissue must be extracted, sent to a lab, stained and analyzed by a pathologist--a process that can take days to complete and is subject to human error.

15 Aug 2018

Researchers discover genetic mutation underlying debilitating childhood brain disorder

Ashleigh Schaffer, PhD, assistant professor of genetics at Case Western Reserve University School of Medicine, and a team of global genetics experts have discovered a genetic mutation and the faulty development process it triggers, causing a debilitating brain-based disorder in children.

9 Aug 2018

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.

7 Aug 2018

Alcohol increases mortality in young mice infected with tuberculosis-causing bacterium

Alcohol increases the mortality of young but not old mice infected with the tuberculosis-causing bacterium Mycobacterium tuberculosis, and this effect is mediated by the production of a protein called interferon-alpha.

3 Aug 2018

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Regenacy Pharmaceuticals, LLC, a clinical-stage biopharmaceutical company developing breakthrough treatments for diabetic and other peripheral neuropathies, today announced a collaboration with the Charcot-Marie-Tooth Association, a registered non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of Charcot-Marie-Tooth disease and evaluate the efficacy of ricolinostat, a selective HDAC6 inhibitor, in animal models.

2 Aug 2018

Cancer cells proliferate less when their internal pH is lowered, study shows

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.

31 Jul 2018

Intracellular News and Research

Purifying Proteins from Mammalian Cell Culture

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

Researchers describe mechanism that sets stage for fate decision of T cells

Dopamine receptor study opens door to targeted treatments for neuropsychiatric disorders

Research team to investigate how blood flow influences formation of plaque

International research effort yields 'Image-Activated Cell Sorting' technology

'Plastic antibodies' effectively target and eliminate tumor cells

Lowering pH inside tumor cells can slow down spread of cancer

Discovery may help broaden the scope of defenses against HPV

Real-time dynamic monitoring of cell's nucleus for effective cancer screening

Researchers discover genetic mutation underlying debilitating childhood brain disorder

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Alcohol increases mortality in young mice infected with tuberculosis-causing bacterium

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Cancer cells proliferate less when their internal pH is lowered, study shows

Researchers describe strategy used by Oropouche virus to replicate in human cells

New control system regulates morphology, orientation of cells constituting animal tissues

New applications for high-throughput flow cytometry in drug discovery

Study finds new enzyme that lays foundations for allergic immune response

New super-resolution 'nanoscope' provides insight into progression of Alzheimer's disease

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