Translation News and Research

RSS

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

SARS-CoV-2 WA1/2020, Delta and Omicron strains found to infect human sensory neurons

Researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the peripheral nervous system (PNS).

13 Jan 2023

ADDF-Harrington partnership accelerates the translation of innovative Alzheimer's research into therapies

The Alzheimer's Drug Discovery Foundation and Harrington Discovery Institute at University Hospitals in Cleveland have granted an ADDF-Harrington Scholar Award to Christiane Wrann, PhD, DVM, Associate Professor in Medicine at the Cardiovascular Research Center and the McCance Center for Brain Health at Massachusetts General Hospital and the Harvard Medical School in Boston.

12 Jan 2023

Simple method increases the efficacy of T cell therapy by cytokine conjugation

The recent years have seen a wave of adoptive cell therapies (ACTs), a type of immunotherapy in which T cells (T cell transfer therapy) and other immune cells are obtained from patients, activated and multiplied outside the body, and infused in larger numbers back into the blood circulation to help fight cancers.

11 Jan 2023

Study identifies LAP1 as a master regulator of nuclear envelope remodeling during melanoma progression

Researchers discovered that the elevated expression of LAP1, an inner nuclear membrane protein, helps metastatic melanoma cells surmount the physical challenges presented by tissue structure and the microenvironment during metastasis.

11 Jan 2023

Researchers discover the Nrf3-mediated mechanism of melanogenesis

The skin is presumably the largest and one of the most versatile body organs. By providing a physical barrier, it protects our body from environmental assaults.

11 Jan 2023

Can diets reverse or delay aging?

A new study published in the journal Science aimed to summarize the commonly studied anti-aging dietary interventions and their impact on human health and longevity.

10 Jan 2023

Researchers review bacteriophage treatment

Researchers presented an overview of bacteriophage treatment, including mechanisms, types, design and applications of bacteriophage therapy.

10 Jan 2023

Researchers develop a novel, improved system for identifying fluorescent agents

The nascent field of fluorescence-guided surgery (FGS) is fast growing, with potential to vastly improve the safety and efficacy of surgical procedures.

9 Jan 2023

CU researchers discover a new mechanism for slowing cardiac fibrosis

Researchers at the University of Colorado School of Medicine have discovered a new mechanism for slowing scarring of heart tissue - a process known as cardiac fibrosis.

6 Jan 2023

Study offers novel insights into the elongation dynamics of eukaryotic cells

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of amino acid sequences taking place in the ribosomes.

5 Jan 2023

Researchers develop a new approach to better understand the biology of polycystic kidney disease

A research team supported by the National Institutes of Health has developed a new approach to better understand the biology of polycystic kidney disease (PKD), an often-life-threatening genetic disorder that affects millions worldwide.

5 Jan 2023

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

Researchers uncovered a novel mechanism that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses (CoVs) use to exploit host antiviral immune system to facilitate their replication.

5 Jan 2023

New research extensively explores 12 distinctive aging traits

In a recent article published in Cell, researchers proposed that 12 distinctive traits of aging are all inter-related.

5 Jan 2023

Why do some people develop persistent lung sequelae after severe COVID-19?

Clinical presentation following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from mild self-limiting illness to severe respiratory failure. Many studies have analyzed the early acute phases of coronavirus disease 2019(COVID-19), but few focused on the longer-term sequelae following infection.

2 Jan 2023

Novel bacterial therapy approach opens up new treatment options for lung cancer patients

Lung cancer is the deadliest cancer in the United States and around the world. Many of the currently available therapies have been ineffective, leaving patients with very few options.

26 Dec 2022

UC San Diego researchers rewrite the textbook on gene regulation

A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation.

22 Dec 2022

Impact of epigenetics on the clinical management of cancer patients

Dr. Manel Esteller and Dr. Verónica Dávalos, researchers at the Josep Carreras Leukaemia Research Institute, describe in a new article the impact of epigenetics on cancer treatment and how it has become a crucial tool to improve early detection, predict disease progression and become a target for new treatments.

22 Dec 2022

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

Researchers investigated the mechanisms through which the human common cold Betacoronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit the formation of stress granules.

21 Dec 2022

Using 3D patient tumor avatars to guide cancer treatment decisions

At any time, most cancer patients are receiving a treatment that does not significantly benefit them while enduring bodily and financial toxicity.

20 Dec 2022

Translation News and Research

The loss of epigenetic information accelerates the aging process

SARS-CoV-2 WA1/2020, Delta and Omicron strains found to infect human sensory neurons

ADDF-Harrington partnership accelerates the translation of innovative Alzheimer's research into therapies

Simple method increases the efficacy of T cell therapy by cytokine conjugation

Study identifies LAP1 as a master regulator of nuclear envelope remodeling during melanoma progression

Researchers discover the Nrf3-mediated mechanism of melanogenesis

Can diets reverse or delay aging?

Researchers review bacteriophage treatment

Researchers develop a novel, improved system for identifying fluorescent agents

CU researchers discover a new mechanism for slowing cardiac fibrosis

Study offers novel insights into the elongation dynamics of eukaryotic cells

Researchers develop a new approach to better understand the biology of polycystic kidney disease

What is the role of SARS-CoV-2 non-structural protein 2 in repressing host antiviral immunity?

New research extensively explores 12 distinctive aging traits

Why do some people develop persistent lung sequelae after severe COVID-19?

Novel bacterial therapy approach opens up new treatment options for lung cancer patients

UC San Diego researchers rewrite the textbook on gene regulation

Impact of epigenetics on the clinical management of cancer patients

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

Using 3D patient tumor avatars to guide cancer treatment decisions

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News