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Freeze-dried gene therapy system safe and effective for treating brain cancer

Researchers at the Johns Hopkins University School of Medicine have developed a technique that delivers gene therapy into human brain cancer cells using nanoparticles that can be freeze-dried and stored for up to three months prior to use. The shelf-stable particles may obviate the need for virus-mediated gene therapy, which has been associated with safety concerns.

7 Jul 2011

Scientists reveal that 'detox' protein could trigger pancreatic, lung cancer development

CANCER RESEARCH UK scientists have revealed that a 'detox' protein which mops up harmful 'reactive oxygen' in cells could also trigger pancreatic and lung cancer development, according to a study published in Nature, today.

7 Jul 2011

Experiment to protect astronauts from bone loss during micro-gravity exposure

Researchers in the University of North Carolina at Chapel Hill/North Carolina State University Joint Department of Biomedical Engineering will be at the Kennedy Space Center for the last space shuttle launch of the NASA program as Atlantis departs for its final mission into Earth's orbit.

6 Jul 2011

New technique explores how cells react to rapidly changing patterns of chemoattractants

Many cell types in higher organisms are capable of implementing directed motion in response to the presence of certain chemical attractants in their vicinity. A team led by Dr. Doris Heinrich of the Faculty of Physics and the Center for NanoScience (CeNS) at Ludwig-Maximilians-Universit-t (LMU) in Munich has developed a novel technique to expose an ensemble of living cells to rapidly varying concentrations of chemoattractants.

6 Jul 2011

Scientists discover three unexpected RNAs involved in diabetes cell-death pathway

Excess nutrients, such as fat and sugar, don't just pack on the pounds but can push some cells in the body over the brink. Unable to tolerate this "toxic" environment, these cells commit suicide.

6 Jul 2011

Study highlights importance of mRNA translation in aging process

When researchers at the Buck Institute dialed back activity of a specific mRNA translation factor in adult nematode worms they saw an unexpected genome-wide response that effectively increased activity in specific stress response genes that could help explain why the worms lived 40 percent longer under this condition.

6 Jul 2011

More evidence needed to determine how diets can reduce hypertension in individuals

New research by a University of Kent pharmacist should reveal more evidence about how diets can reduce blood pressure and other risk factors for heart disease in different individuals.

6 Jul 2011

Potential new approach for treating obesity, type 2 diabetes

Scientists at the National Institutes of Health have uncovered a pathway in mice that allows white fat - a contributor to obesity and type 2 diabetes - to burn calories in a way that's normally found in brown fat and muscle. The findings are in the July 6 edition of Cell Metabolism.

6 Jul 2011

Alpha-tocotrienol protects brain cells after stroke in three ways

A natural form of vitamin E called alpha-tocotrienol can trigger production of a protein in the brain that clears toxins from nerve cells, preventing those cells from dying after a stroke, new research shows.

6 Jul 2011

Practices associated with successful weight loss versus maintenance

A new study indicates that the practices that help people to lose weight and the practices that help them keep it off do not overlap much.

5 Jul 2011

Fruit flies with poor posture help scientists understand human intellectual disability

Clumsy fruit flies with poor posture are helping an international team of scientists understand inherited intellectual disability in humans - and vice versa.

5 Jul 2011

Simple blood test for melanoma-inhibitory activity could detect neurofibromas

Neurofibromatosis (NF1) is a genetic condition which affects one in every 3,000 people. The severity of symptoms can range from benign 'café au lait' patches on the skin, through small tumors under the skin and deep plexiform neurofibromas, to malignant tumors of the nerve sheath.

4 Jul 2011

MGH researchers discover new plant compounds that block blood vessel growth

Massachusetts General Hospital (MGH) researchers have discovered the first of an entirely new class of antiangiogenesis drugs - agents that interfere with the development of blood vessels.

2 Jul 2011

Children with dairy allergies can benefit from foods that contain baked milk

Introducing increasing amounts of foods that contain baked milk into the diets of children who have milk allergies helped a majority of them outgrow their allergies, according to a study conducted at Mount Sinai School of Medicine's Jaffe Food Allergy Institute.

2 Jul 2011

Checklist to stay healthy and active in summer

The summer is a great season for getting in shape. Whether by playing a sport, doing an aerobic exercise routine, or just returning to that familiar running path -- this is the time for activity.

2 Jul 2011

Small molecule treatment holds promise for Usher syndrome

New treatment approach shall soon be ready for use in Usher syndrome patients / Publication in "Human Gene Therapy".

1 Jul 2011

Amylin behaves when guarded by zinc

In type 2 diabetes, a protein called amylin forms dense clumps that shut down insulin-producing cells, wreaking havoc on the control of blood sugar. But zinc has a knack for preventing amylin from misbehaving.

1 Jul 2011

Study identifies key virus-sensing mechanism necessary for successful immune response against HIV

Although our body's defense mechanisms are usually capable of detecting and destroying many types of pathogens, some viruses are able to evade the immune system and make us sick. In particular, "retroviruses," such as human immunodeficiency virus (HIV), are notorious for eluding host immune defenses and causing disease.

1 Jul 2011

Scientists discover enzyme that can regulate breast cancer development

Researchers at Cold Spring Harbor Laboratory (CSHL) have identified an enzyme that appears to be a significant regulator of breast cancer development. Called PTPN23, the enzyme is a member of a family called protein tyrosine phosphatases, or PTPs, that plays a fundamental role in switching cell signaling on and off.

1 Jul 2011

Researchers identify altered expression of endogenous retroviruses in BSE-infected macaques

Prion diseases such as Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy (BSE) in cattle are transmissible neurodegenerative diseases linked to the aggregation of the prion protein in the central nervous system.

1 Jul 2011

G Protein News and Research

Freeze-dried gene therapy system safe and effective for treating brain cancer

Scientists reveal that 'detox' protein could trigger pancreatic, lung cancer development

Experiment to protect astronauts from bone loss during micro-gravity exposure

New technique explores how cells react to rapidly changing patterns of chemoattractants

Scientists discover three unexpected RNAs involved in diabetes cell-death pathway

Study highlights importance of mRNA translation in aging process

More evidence needed to determine how diets can reduce hypertension in individuals

Potential new approach for treating obesity, type 2 diabetes

Alpha-tocotrienol protects brain cells after stroke in three ways

Practices associated with successful weight loss versus maintenance

Fruit flies with poor posture help scientists understand human intellectual disability

Simple blood test for melanoma-inhibitory activity could detect neurofibromas

MGH researchers discover new plant compounds that block blood vessel growth

Children with dairy allergies can benefit from foods that contain baked milk

Checklist to stay healthy and active in summer

Small molecule treatment holds promise for Usher syndrome

Amylin behaves when guarded by zinc

Study identifies key virus-sensing mechanism necessary for successful immune response against HIV

Scientists discover enzyme that can regulate breast cancer development

Researchers identify altered expression of endogenous retroviruses in BSE-infected macaques

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