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Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

New research undertaken by researchers in the USA describes two parallel but distinct in vivo approaches for the accelerated discovery of antibodies targeting SARS-CoV-2 spike protein.

3 Jun 2021

How bacterial cells have been engineered to produce virus-resistant synthetic polymers

A recent Science paper discusses the utilization of a previously reported synthetic Escherichia coli to produce virus-resistant synthetic polymers.

3 Jun 2021

Study compares Pfizer and Moderna mRNA vaccine-elicited response to SARS-CoV-2 variants

A new study has been published on the bioRxiv preprint server which focuses on the correlation between the vaccine-triggered Immunoglobulin G (IgG) levels and neutralization titers against SARS-CoV-2 variants. Further, neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351), using Pfizer or Moderna vaccine, sera were assessed.

3 Jun 2021

Cdkn1a transcript variant 2 is selectively elevated during natural aging across mouse tissues

Aging published "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" which reported that cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16Ink4a and p21Cip1/Waf1.

3 Jun 2021

SARS-CoV-2 exploits metal-dependent mechanism to evade immune surveillance

Scientists from The University of Texas Health Science Center at San Antonio have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions -- positively charged atoms such as magnesium, manganese and calcium -- are observed in hospitalized COVID-19 patients.

3 Jun 2021

Researchers detect Zika virus RNA in free-ranging African bats

A team of Colorado State University scientists, led by veterinary postdoctoral fellow Dr. Anna Fagre, has detected Zika virus RNA in free-ranging African bats. RNA, or ribonucleic acid, is a molecule that plays a central role in the function of genes.

3 Jun 2021

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Oncotarget published "A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas" which reported that the incidence of human papillomavirus-positive head and neck squamous cell carcinoma has increased dramatically over the past decades due to an increase in infection of the oral mucosa by HPV.

3 Jun 2021

Single mutation to bat virus spike protein allows cell entry using human ACE2

In a paper recently uploaded to the preprint server bioRxiv by Kirchhoff et al. (May 31st, 2021) it is demonstrated that a single mutation to the RaTG13 spike protein results in significantly greater affinity towards the human receptor, indicating that the presence of a positively charged amino group at this position better facilitates interaction with the human ACE2 receptor, and helping to identify other viruses with zoonotic potential.

3 Jun 2021

Epigenetic regulation affects the 3D structure of genome

All the cells of an organism share the same DNA sequence, but their functions, shapes or even lifespans vary greatly. This happens because each cell "reads" different chapters of the genome, thus producing alternative sets of proteins and embarking on different paths.

3 Jun 2021

New research sheds light on the origins of synovial sarcoma

A new study published today in Cancer Discovery, a journal of the American Association for Cancer Research, reports findings that may change the understanding of how synovial sarcoma develops and spreads.

3 Jun 2021

New study will help design better antibodies for potential treatments

Scientists are harnessing hard X-rays in the fight against cancer. A team of researchers, in conjunction with the U.S. Department of Energy's (DOE) Argonne National Laboratory, has used ultrabright X-ray light to determine how specific types of antibodies can tell the difference between different forms of a cancer-linked molecule.

3 Jun 2021

Hydroxychloroquine + Azithromycin therapy at a higher dose improved survival by nearly 200% in ventilated COVID patients

However, a fascinating new study posted to the medRxiv* preprint server suggests that such disappointment may have been both premature and unwarranted, based on a re-analysis of over 250 patients on invasive mechanical ventilation (IMV) during the first two months of the pandemic.

2 Jun 2021

People taking anti-inflammatory drug mount a weaker immune response to COVID-19 vaccine

One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows.

2 Jun 2021

Researchers gain new insights into the structure of cancer-promoting Ras protein

Almost all attempts to use the Ras protein as a point of attack for medications have so far failed. New knowledge concerning its structure is raising hopes of options in the development of medications.

2 Jun 2021

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

A new medRxiv* preprint reports the immunomodulatory effect of the E484K mutation newly acquired by the United Kingdom (U.K.) variant.

2 Jun 2021

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

A new bioRxiv* preprint reports on the successful use of a protocol to expand SARS-CoV-2-reactive T-cells a thousand-fold.

2 Jun 2021

Newly identified protein could become a target for future cancer treatments

Researchers at the Francis Crick Institute have identified a protein that helps tumours evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target for future cancer treatments.

2 Jun 2021

Sinai Health researchers provide an ultra-detailed look at the organization of human cells

Researchers from Sinai Health have published a study providing an ultra-detailed look at the organization of a living human cell, providing a new tool that can help scientists around the world better understand what happens during disease.

2 Jun 2021

Novel SARS-CoV-2 variants partially resistant to infection- and vaccine-induced immunity, study finds

A recent study conducted by a team of scientists in the Netherlands has revealed that while severely affected hospitalized COVID-19 patients and vaccinated individuals are capable of neutralizing the B.1.1.7, B.1.351, and P.1 variants of SARS-CoV-2, a significant proportion of non-hospitalized patients with less severe COVID-19 remain susceptible to these viral variants.

2 Jun 2021

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Researchers at the University of Eastern Finland have uncovered potential mechanisms by which microRNAs (miRNA) drive atherogenesis in a cell-type-specific manner.

2 Jun 2021

Protein C News and Research

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

How bacterial cells have been engineered to produce virus-resistant synthetic polymers

Study compares Pfizer and Moderna mRNA vaccine-elicited response to SARS-CoV-2 variants

Cdkn1a transcript variant 2 is selectively elevated during natural aging across mouse tissues

SARS-CoV-2 exploits metal-dependent mechanism to evade immune surveillance

Researchers detect Zika virus RNA in free-ranging African bats

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Single mutation to bat virus spike protein allows cell entry using human ACE2

Epigenetic regulation affects the 3D structure of genome

New research sheds light on the origins of synovial sarcoma

New study will help design better antibodies for potential treatments

Hydroxychloroquine + Azithromycin therapy at a higher dose improved survival by nearly 200% in ventilated COVID patients

People taking anti-inflammatory drug mount a weaker immune response to COVID-19 vaccine

Researchers gain new insights into the structure of cancer-promoting Ras protein

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

Newly identified protein could become a target for future cancer treatments

Sinai Health researchers provide an ultra-detailed look at the organization of human cells

Novel SARS-CoV-2 variants partially resistant to infection- and vaccine-induced immunity, study finds

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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