Clinical Trial News and Research

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Nighttime pistachio consumption affects gut bacteria in adults with prediabetes

Prediabetes affects a third of people in the United States and most of them will develop Type 2 diabetes, yet effective dietary intervention strategies remain limited.

14 Jul 2025

Early-career physician-scientists receive major support from Damon Runyon Cancer Research Foundation

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

14 Jul 2025

EAGLE model predicts key lung cancer mutations from routine biopsy

With EAGLE, lung cancer biopsy analysis is expedited, accurately predicting EGFR mutations and streamlining the diagnostic process for better patient outcomes.

14 Jul 2025

Intermittent energy restriction shows strong benefits for people with obesity and type 2 diabetes

Intermittent energy restriction, time-restricted eating and continuous energy restriction can all improve blood sugar levels and body weight in people with obesity and type 2 diabetes, according to a study being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

13 Jul 2025

Long-term survival achieved in stage III melanoma with pre-surgery immunotherapy

Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led by researchers at The University of Texas MD Anderson Cancer Center.

12 Jul 2025

Stereotactic radiation shows promise for small cell lung cancer with brain metastases

A new study led by investigators from Mass General Brigham trialed stereotactic (targeted) brain-directed radiation in 100 patients with small cell lung cancer and brain metastases, finding they experienced positive outcomes that support use of targeted radiation in the future for such patients.

12 Jul 2025

Teclistamab shows promising results in heavily pretreated multiple myeloma

Teclistamab-cqyv (Tecvayli) led to clinically meaningful responses in patients with heavily pretreated multiple myeloma who would have been ineligible for the MajesTEC-1 trial, and identified a novel factor independently associated with outcomes.

12 Jul 2025

Small group coaching reduces physician burnout more effectively than one-on-one method

New UCLA research finds that small group professional coaching can reduce physician burnout rates by up to 30%, suggesting that it is more effective than the traditional, and more expensive, one-on-one coaching method.

11 Jul 2025

Children face similar risk of dehydration and hyperthermia in extreme heat as adults

New research from the University of Sydney has found that children are at a similar risk of dehydration and hyperthermia in extreme heat as adults, contradicting previous advice that children are more susceptible to heat-related illnesses.

11 Jul 2025

Ultrasound technique enhances decision making for reduced fetal movement

It can be difficult to decide whether to expedite birth when a woman in the final stage of pregnancy perceives less fetal movements.

11 Jul 2025

New chemotherapy regimen improves fertility outcomes in young Hodgkin's lymphoma patients

Young patients with advanced Hodgkin's lymphoma, a cancer of the lymphatic system, now have a better chance of having their own children after treatment.

10 Jul 2025

Updated NeoVax cancer vaccine shows improved immune response in melanoma trial

Results of a Dana-Farber Cancer Institute-initiated phase 1 clinical trial for patients with melanoma show that an updated formula and delivery of the NeoVax personalized cancer vaccine called NeoVaxMI is safe, feasible, and improves the vaccine-specific immune response compared to previous trials of the platform.

10 Jul 2025

Early skin-to-skin contact boosts breastfeeding in premature babies

More premature babies who had early skin-to-skin contact with their mother were being breastfed at the time of discharge from hospital and for up to one year afterwards. However, this is far from the only benefit.

10 Jul 2025

Slower speech response linked to sleepiness in older adults

A new study led by UCLA investigators shows that Verbal Reaction Time (VRT), the amount of time it takes a person to respond verbally, can be a marker of sleepiness in older adults.

9 Jul 2025

Transabdominal cerclage reduces risk of preterm birth for women with history of cervical insufficiency

A new study by investigators from Mass General Brigham adds evidence that the most effective way to prevent preterm birth among patients with a history of cervical insufficiency is to place a cervical stitch higher in the abdomen rather than vaginally.

9 Jul 2025

Improving sleep and lifestyle could reduce heart disease risk in menopausal women

During the menopause transition, only 1 in 5 women have optimal scores using the American Heart Association's health-assessment tool, known as Life's Essential 8 (LE8).

9 Jul 2025

Blood flow restriction can match gym gains without joint strain

A clinical trial compares high-intensity resistance training and blood flow restriction methods, revealing effective alternatives for muscle strength gains.

9 Jul 2025

Mindfulness meditation boosts attention across all age groups

A new study from the USC Leonard Davis School of Gerontology reveals that just 30 days of guided mindfulness meditation can significantly enhance key aspects of attentional control - especially how quickly and accurately people direct their focus - regardless of age.

9 Jul 2025

Genetically modified herpes virus shows promise against advanced melanoma

The herpes simplex virus type 1 (HSV-1), which affects almost two-thirds of the world's population and is generally associated with oral herpes, may cause painful cold sores or fever blisters around the mouth.

9 Jul 2025

Study identifies why some prostate cancers fail to respond to treatment

A new study from University of Michigan Rogel Cancer Center researchers identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment.

8 Jul 2025

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Clinical Trial News and Research

Nighttime pistachio consumption affects gut bacteria in adults with prediabetes

Early-career physician-scientists receive major support from Damon Runyon Cancer Research Foundation

EAGLE model predicts key lung cancer mutations from routine biopsy

Intermittent energy restriction shows strong benefits for people with obesity and type 2 diabetes

Long-term survival achieved in stage III melanoma with pre-surgery immunotherapy

Stereotactic radiation shows promise for small cell lung cancer with brain metastases

Teclistamab shows promising results in heavily pretreated multiple myeloma

Small group coaching reduces physician burnout more effectively than one-on-one method

Children face similar risk of dehydration and hyperthermia in extreme heat as adults

Ultrasound technique enhances decision making for reduced fetal movement

New chemotherapy regimen improves fertility outcomes in young Hodgkin's lymphoma patients

Updated NeoVax cancer vaccine shows improved immune response in melanoma trial

Early skin-to-skin contact boosts breastfeeding in premature babies

Slower speech response linked to sleepiness in older adults

Transabdominal cerclage reduces risk of preterm birth for women with history of cervical insufficiency

Improving sleep and lifestyle could reduce heart disease risk in menopausal women

Blood flow restriction can match gym gains without joint strain

Mindfulness meditation boosts attention across all age groups

Genetically modified herpes virus shows promise against advanced melanoma

Study identifies why some prostate cancers fail to respond to treatment

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