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Lack of Alix protein leads to occurrence of hydrocephalus in the brain

A team led by researchers at St. Jude Children's Research Hospital report that mice lacking the protein Alix develop hydrocephalus or "water on the brain." Alix ensures that epithelial cells of the choroid plexus are oriented correctly with respect to one another to prevent compromise of the epithelial barrier.

23 Jun 2016

Metal ions released by implant wear can damage progenitors of bone-forming cells

In metal-on-metal pairings, both the shell and head of an implant consist of a cobalt-chromium-molybdenum alloy. The release of metal ions into the body has been reported as a result of implant wear. Bone loss (osteolysis) was observed in many cases.

22 Jun 2016

Study suggests how expression, function of nAChRs regulated in AD

Nicotinic acetylcholine receptors (nAChRs) have been pursued for decades as potential molecular targets to treat cognitive dysfunction in Alzheimer's disease (AD) due to their demonstrated role in processes underlying cognition such as synaptic facilitation, and theta and gamma wave activity.

20 Jun 2016

Researchers uncover mechanism of two-in-one sensor protein KdpD

Uptake of potassium by bacteria is regulated by a single protein that senses the concentration of this cation both inside the cell and in the external medium, and controls the expression of the corresponding transport protein accordingly.

20 Jun 2016

Postnova reports advances in analysis of plasma proteins using AF4-ICP-MS system

Postnova Analytics reports on exciting advances in the analysis of plasma proteins using a hyphenated system that couples asymmetric flow Field-Flow Fractionation (AF4) and inductively coupled plasma-mass spectrometry.

From Postnova Analytics 13 Jun 2016

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo.

9 Jun 2016

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

Professor Claudio Luchinat, University of Florence and co-founder of the Magnetic Resonance Center (CERM), speaks to News-Medical about his research in NMR-based metabolomics.

From Bruker BioSpin Group 9 Jun 2016

Innovative RapifleX MALDI-TOF/TOF showcased by Bruker

At the 64th ASMS Conference, Bruker introducesrapifleX™, the highest performance MALDI-TOF/TOF mass spectrometer, which had been shown as work-in-progress to early adopters at HUPO 2015.

From Bruker Daltonics 7 Jun 2016

Spider venom helps investigate pain signals experienced by irritable bowel syndrome patients

Spiders have helped researchers from Australia and the US discover a new target for irritable bowel syndrome pain.

7 Jun 2016

Introducing the innovative timsTOF mass spectrometer

At the 64th ASMS Conference, Bruker introduces an entirely new mass spectrometry technology platform: the innovative timsTOF™ system combines very high ion mobility resolution greater than 200, using Bruker’s proprietary Trapped Ion Mobility Spectrometry (TIMS), with Bruker’s ultra-high performance ESI-QTOF mass spectrometry.

From Bruker Daltonics 7 Jun 2016

Researchers prove existence of olfactory receptor in pigment-producing skin cells

Researchers at Ruhr-Universität Bochum were the first ones to prove the existence of an olfactory receptor in pigment-producing cells in human skin, the so-called melanocytes. The team headed by Prof Dr Dr Dr habil. Hanns Hatt demonstrated that the violet-like scent Beta-Ionone can activate the receptor.

4 Jun 2016

Duke scientists discover new small-molecule drugs to treat chronic pain

A research team at Duke University has discovered a potential new class of small-molecule drugs that simultaneously block two sought-after targets in the treatment of pain.

1 Jun 2016

RNA molecular dynamics research provides key insights into new treatments for retroviral diseases

New molecular dynamics research into how RNA folds into hairpin-shaped structures called tetraloops could provide important insights into new treatments for retroviral diseases.

1 Jun 2016

New player in calcium signalling pathways acts as molecular brake to Orai activation

Information flow in cells relies on calcium as a key agent in several signalling pathways. Calcium dependent signalling is crucial in nearly every aspect of life - muscle movement, immune reactions, nerve function, light sensing and many such processes.

28 May 2016

Study finds that TPC2 protein regulates melanin production

A year and a half ago, researchers at Brown University found a molecular gas pedal for melanin production. Now they've found a brake. For scientists, the finding deepens not only the basic understanding of how eyes, skin and hair gain color, but also what perhaps can be done in disorders, such as albinism, when that doesn't happen.

27 May 2016

Ion News and Research

Lack of Alix protein leads to occurrence of hydrocephalus in the brain

Metal ions released by implant wear can damage progenitors of bone-forming cells

Study suggests how expression, function of nAChRs regulated in AD

Researchers uncover mechanism of two-in-one sensor protein KdpD

Postnova reports advances in analysis of plasma proteins using AF4-ICP-MS system

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

Innovative RapifleX MALDI-TOF/TOF showcased by Bruker

Spider venom helps investigate pain signals experienced by irritable bowel syndrome patients

Introducing the innovative timsTOF mass spectrometer

Researchers prove existence of olfactory receptor in pigment-producing skin cells

Duke scientists discover new small-molecule drugs to treat chronic pain

RNA molecular dynamics research provides key insights into new treatments for retroviral diseases

New player in calcium signalling pathways acts as molecular brake to Orai activation

Study finds that TPC2 protein regulates melanin production

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

TSRI scientists discover new method for harnessing venoms for therapeutic use

Researchers partially restore lost function of isolated cystic fibrosis lung cells

New approach offers unprecedented view of how HIV virus infects and appropriates host cell

Breakthrough study observes structural changes in carbonic anhydrase for first time

Enhancing confidence in chemical ionization spectrometry data eBook

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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