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New gene editing approach could revolutionize the treatment of blood disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

27 Jul 2023

Universal genetic testing may improve risk stratification and treatment for rare and lethal cancer

Esophageal adenocarcinoma (EAC) is a highly lethal cancer, with a five-year survival rate of less than 20 percent. Although a precursor lesion to EAC, called Barrett's esophagus (BE), is present in roughly seven percent of middle-aged adults, less than one percent of BE patients will progress to EAC, making it difficult to determine which individuals are at risk of developing this deadly cancer.

27 Jul 2023

Positive experiences can reverse cognitive decline in old age

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, "MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan."

26 Jul 2023

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Study aimed to understand the specific needs of lung cancer in never smokers (LCINS) patients.

25 Jul 2023

Characterizing the concentration and binding affinity of WT–induced antibodies against the Omicron subvariant BA.1

A recent study characterized the concentration and binding affinity of antibodies induced by SARS-CoV-2 WT strain against the Omicron subvariant BA.1.

25 Jul 2023

Arming phages with heterologous effectors paves the way for successful UTI treatment

Study demonstrated how phage can be engineered to produce bacteriocins and cell wall hydrolases as antimicrobial effector genes.

24 Jul 2023

ECOG-ACRIN launches new trial to evaluate nilotinib and paclitaxel for advanced cancers

The ECOG-ACRIN Cancer Research Group has enrolled the first patient in a new treatment trial to evaluate the effectiveness of adding nilotinib to standard paclitaxel chemotherapy.

20 Jul 2023

Researchers develop novel system to identify new therapeutics for familial hypercholesterolemia

The Mona Lisa, painted by the Italian artist Leonardo da Vinci, is one of the most recognizable paintings in the world. But many people would be surprised to learn that this painting offers the first evidence of a disease called familial hypercholesterolemia (FH).

20 Jul 2023

Study reveals a genetic basis for asymptomatic SARS-CoV-2 infection

People who contract COVID-19 but never develop symptoms – the so-called super dodgers – may have a genetic ace up their sleeve.

20 Jul 2023

Northwestern Medicine scientists discover new therapeutic target for Parkinson’s disease

Northwestern Medicine scientists have uncovered a new mechanism by which mutations in a gene parkin contribute to familial forms of Parkinson's disease.

19 Jul 2023

Epigenetic formatting of satiety gene may increase risk of obesity in women

What determines whether we become overweight? Aside from lifestyle, predisposition plays a role, but genes cannot fully explain the inherited propensity to accumulate excess weight.

19 Jul 2023

Advanced scans can detect hypertrophic cardiomyopathy before symptoms appear

The research, funded by the British Heart Foundation and published in the journal Circulation, opens the prospect of treating the condition at the earliest stages.

19 Jul 2023

Understanding the mechanisms behind rising antifungal drug resistance

In a recent study, researchers addressed the issue of the rise of antifungal drugs-resistant infections and the advent of multidrug-resistant fungal pathogens.

19 Jul 2023

Routine next-generation sequencing can identify BRAF mutations in synovial sarcoma

A new case report was published in Oncotarget's Volume 14 on July 7, 2023, entitled, "Intrathoracic synovial sarcoma with BRAF V600E mutation."

18 Jul 2023

Rice bioengineers receive NIH grant for sickle cell disease research

Rice University bioengineer Gang Bao and his team have won a 4-year, $2.6 million grant from the National Institutes of Health to address critical questions surrounding the safety and efficacy of using gene editing to treat sickle cell disease.

18 Jul 2023

Immunodiagnosis: Unleashing the potential of personalized immunotherapy

Researchers discuss the concept of immunodiagnosis and explores the potential of artificial intelligence in ID systems for precise tumor immunotherapy.

18 Jul 2023

Study sheds light on how viruses override host cell's DNA replication machinery

University of Pittsburgh researchers have shown for the first time how Merkel cell polyomavirus (MCV), which causes an aggressive skin cancer called Merkel cell carcinoma, initiates DNA replication in host cells.

17 Jul 2023

Study shines light on genetic differences among children with rare neurodevelopmental condition

New research led by the Seaver Autism Center for Research and Treatment at Mount Sinai has illuminated genetic differences among children with a rare neurodevelopmental condition and could point the way toward a precision medicine approach to caring for these children.

17 Jul 2023

Study highlights the potential of cell replacement therapy for Huntington's disease

New research appearing in the journal Nature Biotechnology answers important questions about the viability of treatments that seek to replace diseased and aged cells in the central nervous system with healthy ones.

17 Jul 2023

Omicron subvariant BA.5 can cause more severe disease

Omicron-derived virus variants are currently responsible for most SARS-CoV-2 infections worldwide. Compared to earlier virus variants, Omicron rarely causes severe disease.

17 Jul 2023

Mutation News and Research

New gene editing approach could revolutionize the treatment of blood disorders

Universal genetic testing may improve risk stratification and treatment for rare and lethal cancer

Positive experiences can reverse cognitive decline in old age

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Characterizing the concentration and binding affinity of WT–induced antibodies against the Omicron subvariant BA.1

Arming phages with heterologous effectors paves the way for successful UTI treatment

ECOG-ACRIN launches new trial to evaluate nilotinib and paclitaxel for advanced cancers

Researchers develop novel system to identify new therapeutics for familial hypercholesterolemia

Study reveals a genetic basis for asymptomatic SARS-CoV-2 infection

Northwestern Medicine scientists discover new therapeutic target for Parkinson’s disease

Epigenetic formatting of satiety gene may increase risk of obesity in women

Advanced scans can detect hypertrophic cardiomyopathy before symptoms appear

Understanding the mechanisms behind rising antifungal drug resistance

Routine next-generation sequencing can identify BRAF mutations in synovial sarcoma

Rice bioengineers receive NIH grant for sickle cell disease research

Immunodiagnosis: Unleashing the potential of personalized immunotherapy

Study sheds light on how viruses override host cell's DNA replication machinery

Study shines light on genetic differences among children with rare neurodevelopmental condition

Study highlights the potential of cell replacement therapy for Huntington's disease

Omicron subvariant BA.5 can cause more severe disease

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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