Oncology News and Research

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Oncology, meaning bulk, mass, or tumor, and the suffix ''-logy'', meaning "study of") is a branch of medicine that deals with tumors (cancer). A medical professional who practices oncology is an ''oncologist''.

Are Allogeneic CAR-Ts the Future of LBCL Cancer Treatment? - Making Safe, Durable & Effective Universal Cell Therapies a Reality

Allogene Therapeutics recently released exciting results from the Phase 1 ALPHA/ALPHA2 trials of the Allogeneic CAR T 'Cemacabtagene Ansegedleucel/ALLO-501' in Relapsed/Refractory Large B-Cell Lymphoma.

From Hanson Wade Group - 7th Allogeneic Cell Therapies Summit 4 Mar 2025

AI successfully reduces workload in lung cancer screening

A new study by researchers from the University of Liverpool and the Research Institute for Diagnostic Accuracy, Netherlands, has demonstrated that artificial intelligence (AI) can significantly improve the efficiency of lung cancer screening.

4 Mar 2025

Engineered TIMPs show promise in fighting glioblastoma invasion

A new research paper was published in Oncotarget, Volume 16, on February 28, 2025, titled "Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells."

3 Mar 2025

Study elucidates mechanism behind bacterial cancer therapy

A research team led by Prof. Liu Chenli from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences (CAS) and Prof. Xiao Yichuan from the Shanghai Institute of Nutrition and Health of CAS elucidated the mechanism behind bacterial cancer therapy using a genetically engineered bacterial strain.

3 Mar 2025

Study elucidates mechanism connecting ER membrane remodeling to pyroptosis in cancer cells

Pyroptosis, a highly inflammatory type of programmed cell death, has garnered attention for its potential in cancer treatment.

3 Mar 2025

Novel mechanism of PDHX acetylation linked to hepatocellular carcinoma progression

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect.

3 Mar 2025

Co-occurring mutations may limit effectiveness of KRAS G12C inhibitors in colorectal and pancreatic cancer

Colorectal cancer and pancreatic ductal adenocarcinoma that harbored the KRAS G12C mutation often carried other genetic alterations that can be associated with resistance to KRAS G12C inhibitors, despite no prior treatment with this therapy, according to recent results from a large multidatabase analysis.

3 Mar 2025

Study identifies key role of JMJD1C in acute myeloid leukemia

Acute myeloid leukemia (AML) is one of the most aggressive and genetically complex cancers, marked by the unchecked growth of immature myeloid cells.

3 Mar 2025

Stress granules as potential biomarkers for neurodegenerative diseases

Stress granules (SGs) are transient organelles that form when cells experience stress, serving as critical hubs for RNA metabolism and cellular survival.

3 Mar 2025

Skin organoids show promise for treating frostbite injuries

Frostbite is a severe cold injury that affects millions worldwide, often resulting in prolonged recovery, scarring, and long-term complications such as chronic pain and dysfunction.

3 Mar 2025

Advancing precision medicine for childhood cancer treatment

The first phase of the Stratified Medicine Paediatrics (SMPaeds1) programme is advancing precision medicine in the UK to help young cancer patients receive more targeted and less toxic treatments.

28 Feb 2025

New ASTRO guideline offers radiation therapy recommendations for anal cancer

A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance on the use of radiation therapy to treat adult patients with primary squamous cell carcinoma (SCC) of the anal canal and anal margin.

27 Feb 2025

UCLA scientists discover new approach for treating glioblastoma

UCLA scientists have identified a potential new strategy for treating glioblastoma, the deadliest form of brain cancer, by reprogramming aggressive cancer cells into harmless ones.

26 Feb 2025

Researchers aim to detect esophageal precancer with state-of-the-art medical technologies

Researchers at Case Western Reserve University (CWRU) and University Hospitals (UH) will use state-of-the-art medical technologies they invented-and licensed to Lucid Diagnostics Inc.-to detect esophageal precancer, specifically Barrett's Esophagus (BE).

26 Feb 2025

Tardigrade protein offers radiation protection for cancer patients

About 60 percent of all cancer patients in the United States receive radiation therapy as part of their treatment.

26 Feb 2025

Lipid signatures could guide personalized treatment for colorectal cancer

Colorectal cancer, the second most common cause of cancer-related death, affects almost 2 million people worldwide every year.

26 Feb 2025

New antibody-toxin conjugate designed to stimulate immune-mediated eradication of tumors

Researchers at The University of Texas MD Anderson Cancer Center have developed a novel antibody-toxin conjugate (ATC) designed to stimulate immune-mediated eradication of tumors.

25 Feb 2025

Using bioengineered materials to treat chemotherapy-induced oral lesions

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Leukopenia, weight loss and oral mucositis induced by 5-Fluorouracil in hamsters' model: A regenerative approach using electrospun poly(Lactic-co-Glycolic Acid) membrane."

25 Feb 2025

Review highlights next-generation cancer therapies targeting PIK3CA mutations

A newly published review in Genes & Diseases explores the oncogenic activation of PIK3CA in cancer and highlights emerging targeted therapies designed to improve treatment efficacy while reducing side effects.

25 Feb 2025

Study challenges role of BRCA1 mutation in prostate cancer initiation

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its kind, published online in the open access journal BMJ Oncology.

24 Feb 2025