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Pitt researchers to contribute to building an atlas of cellular senescence

Most cells throughout the body can divide and multiply to replace old cells and repair damaged tissue, but in response to certain stresses, cells can lose their ability to proliferate. These so-called senescent cells accumulate with age and may contribute to cancer and age-related disorders, such as chronic lung disease, cardiovascular disease, frailty and dementia, by pumping out signals that damage neighboring tissues.

21 Oct 2021

U-M researchers target a protein channel in the cell’s lysosome to selectively kill cancer cells

Cancer treatments necessarily target unchecked cell growth, and selectively kill cancer cells while sparing normal cells and avoiding general toxicity in the human body.

20 Oct 2021

Watch: Going beyond the script of ‘Dopesick’ and America’s real-life opioid crisis

KHN and policy colleagues at our parent organization KFF teamed up with Hulu for a discussion of America’s opioid crisis, following the Oct. 13 premiere of the online streaming service's new series "Dopesick."

18 Oct 2021

Mapping proteo-genomic connections between different human diseases

Hundreds of connections between different human diseases have been uncovered through their shared origin in our genome by an international research team led by scientists from the Medical Research Council Epidemiology Unit at the University of Cambridge, challenging the categorization of diseases by organ, symptoms, or clinical specialty.

15 Oct 2021

Scientists suggest a new approach to mitigating the collateral damage from antibiotics

Antibiotics help us to treat bacterial infections and save millions of lives each year. But they can also harm the helpful microbes residing in our gut, weakening one of our body's first lines of defense against pathogens and compromising the multiple beneficial effects our microbiota has for our health.

13 Oct 2021

Medicinal plant extract could potentially help curb the opioid epidemic

The extract of the plant Corydalis yanhusuo prevents morphine tolerance and dependence while also reversing opiate addiction, according to a recent study led by the University of California, Irvine. The findings were published in the October issue of the journal Pharmaceuticals.

12 Oct 2021

The public backs Medicare Rx price negotiation even after hearing both sides’ views

As Congress debates cutting prescription drug costs, a poll released Tuesday found the vast majority of adults — regardless of their political party or age — support letting the federal government negotiate drug prices for Medicare beneficiaries and those in private health insurance plans.

12 Oct 2021

Newly developed gel helps improve the effectiveness of immunotherapy in glioblastoma

Pairing a newly developed gel with immunotherapy that was delivered to post-surgical mouse brains with glioblastoma, a highly malignant and deadly cancer, improved the immunotherapy's effectiveness, report researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and colleagues. The findings appeared on Oct. 6, 2021, in Science Advances.

7 Oct 2021

Mouse brain atlas may help understand the complex circuits of the human brain

The circuits of the human brain contain more than 100 billion neurons, each linked to many other neurons via thousands of synaptic connections, resulting in a three-pound organ that is profoundly more complex than the sum of its innumerable parts.

7 Oct 2021

Blacks, Latinos with autoimmune diseases experience poorer outcomes due to modifiable social conditions

Minority populations in the US with multiple sclerosis and other autoimmune diseases experience poorer outcomes due to modifiable social conditions, according to a new USC study.

5 Oct 2021

Cancer patients on chemotherapy have lower immune response to COVID-19 vaccine, study finds

The COVID-19 pandemic has been an especially stressful time for cancer patients undergoing chemotherapy, which attacks not only the cancer, but also the immune cells needed to defend the body from infections.

2 Oct 2021

Pediatric transplant recipients mount a more robust immune response after two COVID-19 vaccine doses

In a study published today in the American Journal of Transplantation, Johns Hopkins Medicine researchers say that children between the ages of 12 and 18 who have received solid organ transplants appear to mount a more robust immune response than their adult counterparts after a standard two-dose vaccination regimen against SARS-CoV-2, the virus that causes COVID-19.

30 Sep 2021

Research points the way to identifying new precision treatments for cancer

Researchers at University of California San Diego and University of California San Francisco have mapped out how hundreds of mutations involved in two types of cancer affect the activity of discrete groups of proteins that are the ultimate actors behind the disease.

30 Sep 2021

Alzheimer’s drug targets people with mild cognitive impairment. What does that mean?

The approval of a controversial new drug for Alzheimer's disease, Aduhelm, is shining a spotlight on mild cognitive impairment — problems with memory, attention, language or other cognitive tasks that exceed changes expected with normal aging.

29 Sep 2021

A daily pill to treat covid could be just months away, scientists say

Within a day of testing positive for covid-19 in June, Miranda Kelly was sick enough to be scared. At 44, with diabetes and high blood pressure, Kelly, a certified nursing assistant, was having trouble breathing, symptoms serious enough to send her to the emergency room.

24 Sep 2021

KHN’s ‘What the Health?’: The autumn of Democrats’ discontent

Democrats in Congress and the White House are feverishly negotiating to pass as much of President Joe Biden's domestic agenda as they can agree on, even as Republicans who oppose much of the increased spending threaten to shut down the government and default on the nation's debt.

23 Sep 2021

Biosimilar drugs are cheaper than biologics. Are they similar enough to switch?

It took years for Elle Moxley to get a diagnosis that explained her crippling gastrointestinal pain, digestion problems, fatigue, and hot, red rashes.

23 Sep 2021

Public health experts ‘flabbergasted’ that Biden still hasn’t picked an FDA chief

President Joe Biden's failure to name someone to lead the Food and Drug Administration, more than 10 months after the election, has flummoxed public health experts who say it's baffling for the agency to be without a permanent leader during a national health crisis.

22 Sep 2021

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Sep 2021

Congress cites KHN investigation in probe of national academies

The House Committee on Oversight and Reform is requesting a ream of documents from the prestigious National Academies of Sciences, Engineering and Medicine, spurred by a recent KHN investigation that revealed deep ties between pharmaceutical companies and two members of a committee that took a pharma-friendly stance in a recent report on drug waste.

21 Sep 2021

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