Mutation News and Research

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AACR's Sixth Annual Landon Awards recognize Richard Kolodner, Douglas Lowy and John Schiller

Scientists whose discoveries have led to fundamental advances in the science and treatment of cancer are the recipients of two prestigious international prizes offered by the Kirk A. and Dorothy P. Landon Foundation and the American Association for Cancer Research.

22 Mar 2007

New dimension to understanding of p53 protein

The p53 protein routinely shuts down damaged cells and is one of our main lines of defence against cancer. Scientists at Karolinska Institutet in Sweden now present new findings on how p53 carries out this all-important function.

21 Mar 2007

Discovery of new cell involved with cancer

Scientists have discovered a new type of cell that appears to play a role in the development of cancer – a highly volatile, precancerous stem cell that can either remain benign or become malignant, depending upon environmental cues.

14 Mar 2007

Researchers uncover genetic sequence responsible for rare form of pancreatic cancer

Pancreatic ductal adenocarcinoma is an almost uniformly fatal disease regardless of the stage at time of diagnosis. However, a small percentage of patients develop a form of ductal adenocarcinoma associated with cystic lesions that can be detected earlier, is less aggressive and has a 50 percent long-term survival rate.

14 Mar 2007

Stem cells delay neurodegeneration in the brain

Sufferers from devastating neurodegenerative diseases have been given some hope by the results of recent research.

12 Mar 2007

Second bird flu death in Laos - 11th country to fall victim to H5N1

The death of a 15-year-old girl from Laos from the deadly H5N1 strain of bird flu, is the country's first officially confirmed victim of the disease.

11 Mar 2007

New discovery suggests novel methods for treating acute lymphoblastic leukemia

Investigators at St. Jude Children's Research Hospital have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children.

8 Mar 2007

China's southern Guangdong Province found to be source of H5N1

A team of scientists at the University of California, Irvine, who have been conducting a genetic analysis of the H5N1 bird flu virus, have found that China's southern Guangdong Province is the source of the deadly strain.

7 Mar 2007

Bird flu vaccine - experts say let's try harder

Experts on viruses are calling for a bigger effort to be made in developing vaccines to tackle pandemics.

6 Mar 2007

Life-saving cancer genetic testing vastly underutilized

A study released today at the Society of Gynecologic Oncologists 38th Annual Meeting on Women's Cancer found few patients were aware of genetic cancer syndromes and the high risk of developing cancer if genetic mutations were found. Fewer still were motivated to follow up on this information with their own healthcare provider or genetic counseling/testing services.

5 Mar 2007

Two experimental drugs aimed at controlling viral loads among HIV-positive people who have developed drug resistance show promise

Two experimental antiretroviral drugs, called TMC278 and elvitegravir, show promise in controlling the viral loads of HIV-positive people who have developed resistance to available drugs, researchers said Wednesday at the 14th Annual Conference on Retroviruses and Opportunistic Infections in Los Angeles, the Los Angeles Times reports.

4 Mar 2007

Another case of bird flu appears in Laos

World Health Organization (WHO) officials say it is likely 42-year-old woman who died in Laos had bird flu.

4 Mar 2007

Bird flu vaccine offers limited protection but 'better than nothing'

Despite evidence it will not protect most people, a panel of health advisers have recommended that the Food and Drug Administration (FDA) in the United States approve the first vaccine against bird flu.

28 Feb 2007

First 3-D structure from key influenza protein revealed

In 1918, 50 million people died during a worldwide influenza pandemic caused by mutation of a bird-specific strain of the influenza virus. Recently H5N1, another highly infectious avian strain has caused outbreaks of bird flu around the world.

27 Feb 2007

Genetically caused deafness may be reversible by compensating for a missing protein

Emory University researchers have found that in mice, increasing the amount of the protein connexin26 in the ear's cochlea compensates for an absence of another protein, connexin30.

26 Feb 2007

Irregular heartbeat linked to genetic mutation

Every day for 10 years, a seemingly heart-healthy 53-year-old woman experienced rapid and irregular heartbeats. She had no personal or family history of hypertension or hyperthyroidism. She did not suffer from myocardial or coronary artery disease, or any abnormalities of the heart as best doctors and medical science could determine.

25 Feb 2007

microRNA directly regulates a gene implicated in human cancers

MicroRNAs are tiny snippets of RNA that can repress activity of a gene by targeting the gene's messenger RNA (which copies DNA information and starts the process of protein production).

22 Feb 2007

Entire genetic blueprints of more than 2,000 human and avian influenza viruses completed and made public

The Influenza Genome Sequencing Project, funded by the National Institute of Allergy and Infectious Diseases (NIAID), announced today that it has achieved a major milestone.

21 Feb 2007

More Moscow suburbs affected by bird flu

Russian officials say two more localities near Moscow have reported what appears to be the highly pathogenic H5N1 strain of bird flu.

21 Feb 2007

New test identifies suitable lymphoma patients likely to respond to new therapy

Researchers at the Albert Einstein College of Medicine of Yeshiva University have discovered a genetic signature identifying cases of lymphoma that are uniquely susceptible to a newly developed molecular targeted therapy. As a result, physicians organizing clinical trials of the new therapy will be able to enroll patients who'll be most likely to benefit from it.

20 Feb 2007