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UBC researchers lead development of new 'toolbox of MiniPromoters' for gene research and therapy

University of British Columbia researchers have led the development of a new "toolbox of MiniPromoters" for research and future therapies on brain, spinal cord and eye function.

31 Aug 2010

New hybrid proteins may lead to better gene replacement and editing therapies

An Iowa State University team of researchers has developed a type of hybrid proteins that can make double-strand DNA breaks at specific sites in living cells, possibly leading to better gene replacement and gene editing therapies.

31 Aug 2010

Scientists develop microarray technology to create blood transcriptional signatures for infectious diseases

It may soon be possible to identify patients who will develop tuberculosis, as scientists have identified changes in the blood specific to the disease. These findings are from an international study published in the August 19 issue of Nature and conducted by doctors and researchers at Nationwide Children's Hospital using blood profiling techniques to understand infections.

30 Aug 2010

New high throughput sequencing technology to identify genetic defects in rare diseases

The majority of rare diseases are hereditary. But despite significant progress in genome research, in most cases their exact cause remains unclear. The discovery of the underlying genetic defect is, however, a prerequisite for their definitive diagnosis and the development of innovative approaches to their treatment. Scientists at the Max Planck Institute for Molecular Genetics and the Institute of Medical Genetics at the Charit- Universit-tsmedizin - Berlin have succeeded in using a new process with which all of the genes in the human genome can be analysed simultaneously.

30 Aug 2010

GWAS finds new genetic link between Parkinson's disease and inflammation

A hunt throughout the human genome for variants associated with common, late-onset Parkinson's disease has revealed a new genetic link that implicates the immune system and offers new targets for drug development.

30 Aug 2010

Natural selection theory can explain evolution of eusocial behavior: Study

Scientists at Harvard University have sketched a new map of the "evolutionary labyrinth" species must traverse to reach eusociality, the rare but spectacularly successful social structure where individuals cooperate to raise offspring.

27 Aug 2010

Gene linked to Fuchs corneal dystrophy discovered

A 13-member research team led by University of Oregon scientist Dr. Albert O. Edwards has found a gene likely responsible for Fuchs corneal dystrophy, an inheritable genetic disorder and leading cause of corneal transplant operations.

26 Aug 2010

Scientists create novel map of lipid locations in single cell

In real estate, location is everything. The same might be said of lipids - those crucial cellular fats and oils that serve as building blocks for cells and as key energy sources for the body.In a paper published in the September issue of the Journal of Lipid Research, a team of scientists, led by researchers at the University of California, San Diego School of Medicine, has mapped for the first time the actual locations of specific lipids within a single cell.

26 Aug 2010

Ambry Genetics acquires Illumina HiSeq 2000 Sequencing and BeadXpress Genotyping systems

Ambry Genetics, a global leader in genomic services, announced today that it has acquired the Illumina HiSeq 2000 Next Generation Sequencing System as well as received the first 510(K) approved Illumina BeadXpress Genotyping System. Ambry Genetics has been an early adapter of Illumina systems since late 2007 and has extensive experience as a Certified Service Provider.

26 Aug 2010

Research finds adenovirus impact on cell's suicide program pave way for new cancer therapy

A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted cancer therapy, report researchers at the Salk Institute for Biological Studies in the Aug. 26, 2010 issue of Nature.

26 Aug 2010

Fox Chase Cancer Center to host Philadelphia Chromosome Symposium

In celebration of a seminal discovery in cancer biology, Fox Chase Cancer Center will host the Philadelphia Chromosome Symposium: Past, Present and Future, on September 28, 2010, from 8 a.m. to 7 p.m. at The Chemical Heritage Foundation, 315 Chestnut Street, Philadelphia. The event marks the 50th anniversary of the discovery of the first genetic abnormality associated with cancer, and the first to lead to a targeted therapy for cancer.

25 Aug 2010

CAS researchers confirm Gleevec’s first generation drug targets chronic myelogenous leukemia

Today, leukemia patients who have struggled with cancer therapy resistance and intolerance will now have more options thanks to targeted drug therapy. Such new treatment options are due, in part, to a rapid increase in journal and patent publications following the discovery of Gleevec, as reported by Chemical Abstracts Service (CAS), the world's authority for chemical information.

25 Aug 2010

Agilent Technologies introduces SureSelect Human All Exon v2 Target Enrichment kit for cancer assay

Agilent Technologies Inc.today introduced the SureSelect Human All Exon v2 Target Enrichment kit, which was developed in close collaboration with the Broad Institute of MIT and Harvard. The kit, the 15th SureSelect product in Agilent's portfolio, is a single tube assay that allows researchers to streamline experiments by sequencing the expressed genome while discarding regions not of interest.

25 Aug 2010

Scientists discover influence of vitamin D in genes linked with autoimmune diseases

UK scientists at the University of Oxford have discovered that vitamin D can affect the activity of more than 200 genes of cells grown in the lab. Some of these genes are known from previous studies to be involved in diseases like diabetes and cancer.

24 Aug 2010

OSDD program aims to develop new drug for tuberculosis

An unlikely effort is underway to lift the veil of nearly-total secrecy that has surrounded the process of developing new prescription drugs for the last century, scientists said today at the 240th National Meeting of the American Chemical Society (ACS). The upheaval in traditional practice would make key data available to college students, university professors, and others in an open, collective process.

24 Aug 2010

Researchers discover unusual property of meiosis may lead to Down syndrome

In a study of egg cells using time-lapse microscopy, researchers at the University of California, San Diego School of Medicine and the Ludwig Institute for Cancer Research have discovered an unusual property of meiosis - cell division that produces reproductive cells in sexually reproducing organisms.

23 Aug 2010

Castor bean genome may help prevent potential bioterrorism events

A research team co-led by scientists from the J. Craig Venter Institute (JCVI) and the Institute for Genome Sciences (IGS), University of Maryland School of Medicine, today published the sequence and analysis of the castor bean (Ricinus communis) genome in Nature Biotechnology.

23 Aug 2010

New diagnostic tool proves cost-effective in identifying rare genetic disorders

Mutations in a single gene can cause several types of developmental brain abnormalities that experts have traditionally considered different disorders. With support from the National Institutes of Health, researchers found those mutations through whole exome sequencing - a new gene scanning technology that cuts the cost and time of searching for rare mutations.

23 Aug 2010

Genetic architecture controlling growth of 'back-up' blood vessels uncovered

Researchers at the University of North Carolina at Chapel Hill School of Medicine have uncovered the genetic architecture controlling the growth of the collateral circulation - the "back-up" blood vessels that can provide oxygen to starved tissues in the event of a heart attack or stroke.

20 Aug 2010

Even low-level exposure to cigarette smoke affects gene function in lungs

Casual smokers may think that smoking a few cigarettes a week is "no big deal." But according to new research from physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, having an infrequent smoke, or being exposed to secondhand smoke, may be doing more harm than people may think. The findings may further support public smoking bans, say the authors.

20 Aug 2010

Genome News and Research

UBC researchers lead development of new 'toolbox of MiniPromoters' for gene research and therapy

New hybrid proteins may lead to better gene replacement and editing therapies

Scientists develop microarray technology to create blood transcriptional signatures for infectious diseases

New high throughput sequencing technology to identify genetic defects in rare diseases

GWAS finds new genetic link between Parkinson's disease and inflammation

Natural selection theory can explain evolution of eusocial behavior: Study

Gene linked to Fuchs corneal dystrophy discovered

Scientists create novel map of lipid locations in single cell

Ambry Genetics acquires Illumina HiSeq 2000 Sequencing and BeadXpress Genotyping systems

Research finds adenovirus impact on cell's suicide program pave way for new cancer therapy

Fox Chase Cancer Center to host Philadelphia Chromosome Symposium

CAS researchers confirm Gleevec’s first generation drug targets chronic myelogenous leukemia

Agilent Technologies introduces SureSelect Human All Exon v2 Target Enrichment kit for cancer assay

Scientists discover influence of vitamin D in genes linked with autoimmune diseases

OSDD program aims to develop new drug for tuberculosis

Researchers discover unusual property of meiosis may lead to Down syndrome

Castor bean genome may help prevent potential bioterrorism events

New diagnostic tool proves cost-effective in identifying rare genetic disorders

Genetic architecture controlling growth of 'back-up' blood vessels uncovered

Even low-level exposure to cigarette smoke affects gene function in lungs

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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