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Microscopic worms in space

A space flight by millions of microscopic worms could help us overcome the numerous threats posed to human health by space travel. The Caenorhabditis elegans (C. elegans) have also given experts an insight into how to block muscle degradation in the sick and elderly.

2 Jun 2011

Positive interim results from Fraunhofer USA CMB's HAC1 influenza vaccine Phase 1 trial

Fraunhofer USA Center for Molecular Biotechnology, a not-for-profit, Delaware-based organization focused on developing a proprietary plant-based protein production platform and its applications in vaccine and therapeutic fields, today announced positive interim results from the first human trial of plant-produced H1N1 influenza vaccine that began on September 13, 2010.

2 Jun 2011

PCF funds 14 new Creativity Awards for advanced prostate cancer research

The Prostate Cancer Foundation today announced that it has funded 14 new Creativity Awards for advanced prostate cancer research. These two-year awards are designed to support innovative research ideas that have the potential to achieve breakthroughs for improved prostate cancer diagnosis and treatment.

2 Jun 2011

Niiki Pharma to present NKP-1339 Phase I trial against metastatic cancer at ASCO 2011

Niiki Pharma announced today that it will present interim data from the ongoing Phase I clinical study for its lead product, NKP-1339, at the 2011 American Society for Clinical Oncology meeting in Chicago, IL.

2 Jun 2011

Adaptimmune announces opening of Phase I/II clinical trial in multiple myeloma

Adaptimmune announced that it has opened a Phase I/II, dual site, two-cohort, open-label clinical trial in multiple myeloma at the University of Maryland and the University of Pennsylvania testing its enhanced T cell receptor T cell therapy.

1 Jun 2011

Elsevier to organise third Current Opinion conference in structural biology, DNA repair

Elsevier, the leading provider of scientific, technical and medical information products and services, is organising the third Current Opinion conference, the Current Opinion in Structural Biology & DNA Repair.

1 Jun 2011

Plasma resuscitation restores damage to endothelial glycocalyx after hemorrhagic shock

Using plasma rather than standard resuscitation fluids seems to improve survival in trauma patients with massive blood loss. Now a new study in animals suggests that this benefit may result from plasma's ability to restore the "endothelial glycocalyx," a special layer lining the blood vessels, reports the June issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

1 Jun 2011

SMPX gene mutation causes hereditary hearing impairment

Excessive noise is not the only thing that causes damage to hearing. In many cases, genetic factors are responsible for the loss of hearing at a young age. Researchers at the Max Planck Institute for Molecular Genetics in Berlin together with colleagues from Nijmegen have discovered a previously unknown genetic cause of progressive hearing impairment: the disease is caused by mutations of the SMPX gene, which is located on the X chromosome.

1 Jun 2011

E64d reduces Aβ levels and improves memory function in brains of Alzheimer's disease mice

Researchers at the University of California, San Diego, the Medical University of South Carolina and American Life Science Pharmaceuticals of San Diego have demonstrated that oral administration of a cysteine protease inhibitor, E64d, not only reduces the build-up of β-amyloid in the brains of animal models for Alzheimer's disease, but also results in a substantial improvement in memory deficit.

1 Jun 2011

Suberoylanilide hydroxamic acid holds promise against familial frontotemporal dementia

A drug already approved for people with cancer shows early potential as a therapy for a common form of dementia, UT Southwestern Medical Center researchers report.

1 Jun 2011

European Commission grants Orphan Drug Designation for CSL Behring's rVIIa-FP to treat hemophilia

CSL Behring announced today that it has been granted Orphan Drug Designations by the European Commission for the development of its recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP), a novel therapy to treat hemophilia A and hemophilia B patients with inhibitors.

1 Jun 2011

Eculizumab effective for treating hemolytic-uremic syndrome from EHEC

In the online version of the New England Journal of Medicine, physicians and scientists in Heidelberg, Montreal, and Paris reported on the successful treatment of three young children who were suffering from a severe hemolytic-uremic syndrome after an infection with enterohemorrhagic Escherichia coli.

1 Jun 2011

Type II diabetes drug may slow or stop breast cancer tumor metastasis

A protein activated by certain drugs already approved for treating Type II diabetes may slow or stop the spread of breast tumors.

1 Jun 2011

Researchers discover new drug target that may effectively prevent onset of Huntington's disease

McMaster University researchers have discovered a new drug target that may be effective at preventing the onset of Huntington's disease, working much the same way heart medications slow the progression of heart disease and reduce heart attacks.

1 Jun 2011

Ampio commences new anti-inflammatory agent Phase 1B trial in osteoarthritis

Ampio Pharmaceuticals, Inc. announced today that it received ethics board approval for a Phase 1B clinical trial in Australia of its biologic anti-inflammatory agent, Ampion.

1 Jun 2011

Research: Gene mutation causes eye disease glaucoma

It is a mutation in a gene that causes the eye disease glaucoma, according to collaborative research conducted by Swedish, Tunisian, and American researchers. The findings were recently published in the journal Nature Genetics.

31 May 2011

Scientists develop carbohydrate-based vaccine against C. difficile infection

There is now a promising vaccine candidate for combating the pathogen which causes one of the most common and dangerous hospital infections. An international team of scientists from the Max Planck Institute of Colloids and Interfaces in Potsdam has developed a vaccine based on a carbohydrate against the Clostridium difficile bacterium, which is known to cause serious gastrointestinal diseases mainly in hospitals.

31 May 2011

Heptares, AstraZeneca partner to discover and develop new GPCR drug targets

AstraZeneca and Heptares Therapeutics today announced they have entered a four-year collaboration focused on the potential discovery and development of new medicines targeting G-protein coupled receptors.

31 May 2011

Scientists study key malaria protein structure to demonstrate how cells grow and move

Researchers from the Walter and Eliza Hall Institute have overturned conventional wisdom on how cell movement across all species is controlled, solving the structure of a protein that cuts power to the cell 'motor'. The protein could be a potential drug target for future malaria and anti-cancer treatments.

31 May 2011

Small noncoding RNA spurs Alzheimer's development

Researchers pinpoint a small RNA that spurs cells to manufacture a particular splice variant of a key neuronal protein, potentially promoting Alzheimer's disease or other types of neurodegeneration.

31 May 2011

G Protein News and Research

Microscopic worms in space

Positive interim results from Fraunhofer USA CMB's HAC1 influenza vaccine Phase 1 trial

PCF funds 14 new Creativity Awards for advanced prostate cancer research

Niiki Pharma to present NKP-1339 Phase I trial against metastatic cancer at ASCO 2011

Adaptimmune announces opening of Phase I/II clinical trial in multiple myeloma

Elsevier to organise third Current Opinion conference in structural biology, DNA repair

Plasma resuscitation restores damage to endothelial glycocalyx after hemorrhagic shock

SMPX gene mutation causes hereditary hearing impairment

E64d reduces Aβ levels and improves memory function in brains of Alzheimer's disease mice

Suberoylanilide hydroxamic acid holds promise against familial frontotemporal dementia

European Commission grants Orphan Drug Designation for CSL Behring's rVIIa-FP to treat hemophilia

Eculizumab effective for treating hemolytic-uremic syndrome from EHEC

Type II diabetes drug may slow or stop breast cancer tumor metastasis

Researchers discover new drug target that may effectively prevent onset of Huntington's disease

Ampio commences new anti-inflammatory agent Phase 1B trial in osteoarthritis

Research: Gene mutation causes eye disease glaucoma

Scientists develop carbohydrate-based vaccine against C. difficile infection

Heptares, AstraZeneca partner to discover and develop new GPCR drug targets

Scientists study key malaria protein structure to demonstrate how cells grow and move

Small noncoding RNA spurs Alzheimer's development

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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