Cell Death News and Research

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U-M researchers target a protein channel in the cell’s lysosome to selectively kill cancer cells

Cancer treatments necessarily target unchecked cell growth, and selectively kill cancer cells while sparing normal cells and avoiding general toxicity in the human body.

20 Oct 2021

Suggested mechanism of SARS-CoV-2 infection inhibition by Mitoxantrone

A group of researchers performed a drug repurposing screen on an FDA-approved anti-cancer drug named Mitoxantrone.

20 Oct 2021

Long-term predictions of immunity after two doses of mRNA vaccine

Researchers from York University has investigated the long-term protection of two mRNA vaccines.

20 Oct 2021

An investigation of three SARS-CoV-2 mRNA doses in multiple sclerosis vaccine non-responders

A clinical study by a team of scientists from Norway aimed to assess the immunogenicity and safety of a third dose of COVID-19 mRNA vaccine in MS patients treated with anti-CD20 therapy or fingolimod. A preprint version of the study, which is yet to undergo peer review, is available on the medRxiv* server.

20 Oct 2021

Researchers discover new way to jump-start the immune system to attack tumors

Immunotherapy is a promising strategy to treat cancer by stimulating the body's own immune system to destroy tumor cells, but it only works for a handful of cancers.

19 Oct 2021

Study identifies the role of a key cell receptor in efferocytosis after ischemic stroke

It's clear that taking out the trash is an essential process in maintaining a clean and tidy home. But did you know that your body has a similar process for waste removal in which damaged cells are "thrown out"? A research team in Japan has recently shed new light on the dynamics of this process—termed efferocytosis—following ischemic stroke.

18 Oct 2021

Common treatment for MIS-C patients likely works by depleting neutrophils

Intravenous immune globulin (IVIG) — a common treatment for multisystem inflammatory syndrome in children (MIS-C) — likely works by depleting immune cells called neutrophils, according to a recent study funded by the National Institutes of Health.

15 Oct 2021

New study finds SARS-CoV-2 causes retinal infection

Can coronavirus disease 2019 (COVID-19) affect the eye? New research suggests the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the eye and infect photoreceptor and retinal ganglion cells. In addition, SARS-CoV-2 infection increases the expression of several inflammatory genes, including the cytokine interleukin 33 (IL33), which is linked to COVID-19 disease and retinal degeneration.

13 Oct 2021

Characterization of circulating neutrophils from hospitalized COVID-19 patients

A new preprint deals with the characterization of neutrophil phenotypes in an attempt to provide biomarkers that can predict severe disease in patients hospitalized with COVID-19.

8 Oct 2021

Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021.

7 Oct 2021

Toxic fatty acids trigger cell death in damaged neurons

Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows.

6 Oct 2021

Researchers identify mechanism that can lead to deafness in rare Norrie disease

A team of Mass Eye and Ear Scientists led by Albert Edge, PhD, working with research fellow Yushi Hayashi, MD, PhD, has identified the mechanism that can lead to deafness in the rare syndrome, Norrie disease.

5 Oct 2021

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

MUSC Hollings Cancer Center researcher Haizhen (Jen) Wang, Ph.D., was awarded a five-year $344,000 per year grant by the National Cancer Institute to pursue her early investigator studies in leukemia.

5 Oct 2021

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

A new study reported that the ZBP1-induced inflammatory signaling pathway is dependent on ubiquitination and RIPK3’s scaffolding ability, independent of cell death.

5 Oct 2021

Damaging DNA builds up in the eyes to drive blinding age-related macular degeneration

Damaging DNA builds up in the eyes of patients with geographic atrophy, an untreatable, poorly understood form of age-related macular degeneration that causes blindness, new research from the University of Virginia School of Medicine reveals.

1 Oct 2021

Researchers discover how a genetic mutation in mice and monkeys interferes with viruses

A nationwide team of researchers, led by scientists at University of Utah Health and The Rockefeller University, has determined how a genetic mutation found in mice and monkeys interferes with viruses such as HIV and Ebola.

30 Sep 2021

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

NIH-funded project to test light therapies to combat Alzheimer’s debilitating effects

Alzheimer's disease is a mind-robbing brain disorder that affects nearly 6.2 million older Americans. Despite decades of research on high-tech drugs, diets, and crossword puzzles, scientists have yet to discover a highly effective treatment for patients.

23 Sep 2021

Gram-positive and -negative bacteria found to be involved in periodontal bone loss

Mouths are filthy, harboring the second largest microbiome of the human body. Some bacteria can help break down food, among other responsibilities; other bacteria can travel into the mouth on food, fingers, pen caps and more to contribute to gum disease and other oral infections.

22 Sep 2021

Repeated injury to the epithelial tissue of airways causes "biological aging" of stem cells

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so.

22 Sep 2021

Cell Death News and Research

U-M researchers target a protein channel in the cell’s lysosome to selectively kill cancer cells

Suggested mechanism of SARS-CoV-2 infection inhibition by Mitoxantrone

Long-term predictions of immunity after two doses of mRNA vaccine

An investigation of three SARS-CoV-2 mRNA doses in multiple sclerosis vaccine non-responders

Researchers discover new way to jump-start the immune system to attack tumors

Study identifies the role of a key cell receptor in efferocytosis after ischemic stroke

Common treatment for MIS-C patients likely works by depleting neutrophils

New study finds SARS-CoV-2 causes retinal infection

Characterization of circulating neutrophils from hospitalized COVID-19 patients

Novel peptide-drug conjugate enhances the efficacy of immunotherapy in preclinical cancer models

Toxic fatty acids trigger cell death in damaged neurons

Researchers identify mechanism that can lead to deafness in rare Norrie disease

Hollings Cancer Center researcher awarded NCI grant to pursue early investigator studies in leukemia

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

Damaging DNA builds up in the eyes to drive blinding age-related macular degeneration

Researchers discover how a genetic mutation in mice and monkeys interferes with viruses

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

NIH-funded project to test light therapies to combat Alzheimer’s debilitating effects

Gram-positive and -negative bacteria found to be involved in periodontal bone loss

Repeated injury to the epithelial tissue of airways causes "biological aging" of stem cells

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

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