Genetic Information News and Research

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Researchers identify new mutation responsible for spinocerebellar ataxia

Using the genetic information of two different families with three generations of disease, researchers have identified a new mutation responsible for a degenerative and ultimately fatal movement disorder. Through induced pluripotent stem cell techniques, researchers also grew neurons from one patient in the laboratory to be used in future experiments.

15 Mar 2016

Scientists map biological networks of genes to gain new insights on disease mechanisms

Innovative software tools allowed the scientists to construct accurate "maps" of gene networks for about 400 different human cell and tissue types, ranging from immune cells to brain tissues, whereas previous studies were limited to just one or few tissues.

11 Mar 2016

IOM report elucidates state of ovarian cancer incidence, treatment and research

Ovarian cancer, one of the deadliest malignancies, is actually a constellation of different cancers that may originate in other organs and should not be treated as a single disease, concludes a new congressionally mandated report on the state of ovarian cancer incidence, treatment and research. The report, published by the Institute of Medicine of the National Academies of Sciences, Engineering, and Medicine, also highlights persistent serious disparities in delivery of care across different groups of women in the U.S., and suggests promising areas for further research.

4 Mar 2016

Study on DNA scrunching may aid in developing new antimicrobial medicines

A research collaboration that combines novel "big-data" informatics tools with expertise in basic biology has uncovered details of an essential process in life: how a crucial enzyme locates the site on DNA where it begins to direct the synthesis of RNA. This finding may aid in the discovery of new antimicrobial medicines, and the powerful technological approaches developed for this research may shed light on other essential cellular processes.

4 Mar 2016

Dr. Benjamin Neale awarded Leena Peltonen Prize for Excellence in Human Genetics

The Leena Peltonen Prize for Excellence in Human Genetics was established in winter 2010 to recognize scientists who are in the early phases of their independent careers. The second award ceremony will take place at the University of Helsinki, Finland, on March 3, 2016.

3 Mar 2016

New MyGene2 web tool may help find genes influencing Mendelian disorders

A new web tool, MyGene2, will enable patients and their families to join clinicians and scientists in the search for genes underlying rare disorders. The sharing of health information also will improve knowledge about how gene variants influence symptoms and other clinical features of Mendelian disorders.

3 Mar 2016

Genetic errors may reduce heart attack risk, study finds

To reduce risk of heart attack, the benefits of a healthy lifestyle are clear. But genetics can still stack the deck. Some people's genes bestow a natural advantage — or disadvantage — in protecting against heart disease, the leading cause of death worldwide.

3 Mar 2016

Common blood test could help predict risk of second stroke

A new discovery about ischemic stroke may allow to doctors to predict a patient's risk of having a second stroke using a commonly performed blood test and their genetic profile.

3 Mar 2016

U-M researchers develop novel mouse model of children's brain cancer

Children with brain cancer may soon get some help from mice with the same disease, thanks to new research from University of Michigan Medical School scientists and their colleagues.

3 Mar 2016

Researchers explore genetically-tailored diets

Genes are the latest trend in nutrition, at least going by the burgeoning legion of Internet companies offering diets tailored to our genetic make-up. These services are relatively affordable and simple to use.

27 Feb 2016

Discovery highlights need to improve patient education about genomics

An overwhelming majority of people with incurable cancer want to hear findings from DNA sequencing of their own tumors and normal cells, and to learn how those results may affect their health and treatment options, Dana Farber Cancer Institute scientists report.

27 Feb 2016

Investigating mechanism behind development of high-grade serous ovarian cancer

Rutgers Cancer Institute of New Jersey researcher Michael L. Gatza, PhD, has received a $747,000 Pathway to Independence Award (R00-CA166228) from the National Cancer Institute to explore the mechanism behind the development of a subtype of ovarian cancer known as high-grade serous ovarian cancer.

24 Feb 2016

FSU researchers explore new method to decipher genetic data for new prostate cancer treatments

Florida State University researchers are working on new approaches to deciphering genetic data that may lead to new, more targeted prostate cancer treatments.

22 Feb 2016

Study shows new RNA letter as regulatory key to control gene expression

DNA, RNA, protein -- the end. Or is it? Until recently, the pattern used to encode genetic information into our cells was considered to be relatively straightforward: four letters (A,G,C,T) for DNA and four (A,G,C,U) for RNA. This equation, however, turned out to be oversimplified -- RNA was holding out.

17 Feb 2016

Bad technology choices contributing to increased drug development costs, say experts

The search for new medicines is becoming unsustainably expensive despite huge technological advances because researchers are using the wrong methods, experts say.

15 Feb 2016

New technique allows better understanding of cellular stress reaction

Stress in the body's cells is both the cause and consequence of inflammatory diseases or cancer. The cells react to stress to protect themselves. Researchers at the University of Zurich have now developed a new technique that allows studying a fundamental response to stress in much more detail than previously possible: the ADP-ribosylation of chromatin.

9 Feb 2016

Abnormal breakage of chromosomes in white blood cells triggers aggressive form of ALL

A research team led by St. Jude Children's Research Hospital scientists has discovered details of how the abnormal breakage and rearrangement of chromosomes in white blood cells triggers a particularly aggressive form of acute lymphoblastic leukemia (ALL). Such leukemias are cancers of white blood cells, in which genetic mutations trigger overproduction of immature cells, called lymphoblasts.

9 Feb 2016

Study sheds light on mechanisms linked to formation of healthy egg cells in humans

Congenital disorders such as Down's syndrome could be better understood, following new insights into how healthy cells are formed.

3 Feb 2016

Research offers novel insights into root causes of schizophrenia

Schizophrenia is a mysterious and devastating disorder that afflicts one percent of the adult population worldwide. Its symptoms — hallucinations, emotional withdrawal, and cognitive impairment — are chronic and typically emerge just as individuals are entering adulthood. Today's medications treat just one of these symptoms (psychosis); treatments for the underlying disease and its many other symptoms have been hard to develop, because no one really understands what causes the disorder.

31 Jan 2016

CNIO team uses network theory to build and study first epigenetic communication network

One of the big questions for which there is still no clear answer in biology is how, based on the four universal letters that make up DNA, it is possible to generate such different organisms as a fly or a human, or the different organs and tissues they comprise. In recent years, researchers have discovered that the system is much more complicated than was originally thought.

29 Jan 2016

Genetic Information News and Research

Researchers identify new mutation responsible for spinocerebellar ataxia

Scientists map biological networks of genes to gain new insights on disease mechanisms

IOM report elucidates state of ovarian cancer incidence, treatment and research

Study on DNA scrunching may aid in developing new antimicrobial medicines

Dr. Benjamin Neale awarded Leena Peltonen Prize for Excellence in Human Genetics

New MyGene2 web tool may help find genes influencing Mendelian disorders

Genetic errors may reduce heart attack risk, study finds

Common blood test could help predict risk of second stroke

U-M researchers develop novel mouse model of children's brain cancer

Researchers explore genetically-tailored diets

Discovery highlights need to improve patient education about genomics

Investigating mechanism behind development of high-grade serous ovarian cancer

FSU researchers explore new method to decipher genetic data for new prostate cancer treatments

Study shows new RNA letter as regulatory key to control gene expression

Bad technology choices contributing to increased drug development costs, say experts

New technique allows better understanding of cellular stress reaction

Abnormal breakage of chromosomes in white blood cells triggers aggressive form of ALL

Study sheds light on mechanisms linked to formation of healthy egg cells in humans

Research offers novel insights into root causes of schizophrenia

CNIO team uses network theory to build and study first epigenetic communication network

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