Hepatology News and Research

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Hepatology is the branch of medicine that incorporates study of liver, gallbladder, biliary tree and pancreas as well as management of their disorders.

Hyperuricemia associated with more severe hepatic ATP depletion in response to fructose intake

Obese patients with type 2 diabetes who consume higher amounts of fructose display reduced levels of liver adenosine triphosphate (ATP)—a compound involved in the energy transfer between cells.

14 Sep 2012

Concise guide to treat children who have swallowed powerful neodymium magnets

Children who swallow powerful neodymium magnets are at risk of serious complications, requiring emergency evaluation and possible treatment. That's the message of a new clinical algorithm published in the September issue of The Journal of Pediatric Gastroenterology and Nutrition, official journal of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN).

5 Sep 2012

Emergency readmission after endoscopy linked to mortality risk

The risk for mortality is significantly increased among patients who are readmitted urgently following endoscopy, compared with other endoscopy patients, a UK study shows.

30 Aug 2012

Removing entire pancreas does not result in unmanageable diabetes in patients with cancer

Removing the entire pancreas in patients with cancer or precancerous cysts in part of the organ does not result in unmanageable diabetes — as many physicians previously believed, research at Mayo Clinic in Florida has found.

30 Aug 2012

Southampton Traffic Light test could easily diagnose liver fibrosis and cirrhosis

A new 'traffic light' test devised by Dr Nick Sheron and colleagues at University of Southampton and Southampton General Hospital could be used in primary care to diagnose liver fibrosis and cirrhosis in high risk populations more easily than at present.

30 Aug 2012

Israel's Ministry of Health approves Medgenics’ INFRADURE Phase I/II clinical trials for hepatitis C

Medgenics, Inc., the developer of Biopump, a novel technology for the sustained production and delivery of therapeutic proteins in patients using their own tissue, today announced that Israel's Ministry of Health (MOH) has approved two Phase I/II clinical trials to assess the safety and efficacy of INFRADURE in patients with hepatitis C.

30 Aug 2012

ICUS applauds FDA's decision to modify U.S. product label for OPTISON ultrasound contrast agent

The International Contrast Ultrasound Society (ICUS) today applauded the FDA's decision to modify the U.S. product label for OPTISON, an ultrasound contrast agent used to improve the accuracy of radiation-free ultrasound scans.

22 Aug 2012

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage.

17 Aug 2012

Study reports new potential NOX inhibitor therapy for liver fibrosis

A study published in the online journal Hepatology reports a potential new NADPH oxidase (NOX) inhibitor therapy for liver fibrosis, a scarring process associated with chronic liver disease that can lead to loss of liver function.

8 Aug 2012

TAT-ARC fusion protein helps treat acute liver failure

Acute liver failure is a life-threatening disease, characterized by a sudden, massive death of liver cells. Unfortunately, few treatment options exist, especially for advanced-stage liver failure. As a last resort a liver transplant may be the only remaining option.

3 Aug 2012

Biomimetic bioartificial livers and cell toxicity assays: an interview with Dr. Joris Braspenning, CEO Medicyte

Biomimetic bioartificial livers are liver organoids based on synthetic equivalents of the human extracellular matrix (ECM) which will be seeded with human cells.

1 Aug 2012

Hyperion Therapeutics announces completion of initial public offering

Hyperion Therapeutics, Inc. announced today the completion of its initial public offering of 5,000,000 shares of common stock.

31 Jul 2012

Gluconeogenesis severely compromised in HCC by IL6-Stat3-mediated activation of miR-23a

As liver cancer develops, tumor cells lose the ability to produce and release glucose into the bloodstream, a key function of healthy liver cells for maintaining needed blood-sugar levels.

31 Jul 2012

EASL calls on the UN to take action to fight against viral hepatitis infection

Marking World Hepatitis Day, the European Association for the Study of the Liver (EASL) calls on the different organizations which make up the United Nations systems to take action to fight against Viral Hepatitis (Hepatitis B and C), a potentially fatal infection of the liver which affects 500 million people.

30 Jul 2012

Hyperion prices initial public offering of 5,000,000 shares of common stock

Hyperion Therapeutics, Inc. announced today the pricing of its initial public offering of 5,000,000 shares of its common stock at $10.00 per share, before underwriting discounts and commissions.

26 Jul 2012

Follow-up exams for patients with celiac disease are often inadequate and highly variable

Follow-up exams for patients with celiac disease are often inadequate and highly variable, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association (AGA).

26 Jul 2012

EMA COMP issues positive opinion to Albireo for A4250

Albireo AB, a biopharmaceutical company specializing in gastroenterology, today announced that the European Medicines Agency Committee for Orphan Medicinal Products (COMP) has issued a positive opinion on an application for orphan medicinal product status for the company's lead hepatology candidate, A4250.

25 Jul 2012

Aspirin use appears to reduce risk of Barrett's esophagus

Aspirin use appears to reduce the risk of Barrett's esophagus (BE), the largest known risk factor for esophageal cancer, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

24 Jul 2012

Scientists identify inhibitors of key enzyme involved in survival of malaria parasite

An international team of scientists, led by researchers from the Department of Pediatrics at the University of California, San Diego School of Medicine, have identified the first reported inhibitors of a key enzyme involved in survival of the parasite responsible for malaria. Their findings, which may provide the basis for anti-malarial drug development, are currently published in the online version of the Journal of Medicinal Chemistry.

20 Jul 2012

HealthHIV, CCO announce new series of CME/CE-certified interactive local live workshops

Clinical Care Options (CCO), a leader in next-generation medical education, information, and publishing for healthcare professionals, announces a new series of CME/CE-certified interactive local live workshops developed and implemented in partnership with HealthHIV, the leading national HIV nonprofit organization building the capacity of primary care providers to integrate HIV care into their practices.

20 Jul 2012

Hepatology News and Research

Further Reading

Hyperuricemia associated with more severe hepatic ATP depletion in response to fructose intake

Concise guide to treat children who have swallowed powerful neodymium magnets

Emergency readmission after endoscopy linked to mortality risk

Removing entire pancreas does not result in unmanageable diabetes in patients with cancer

Southampton Traffic Light test could easily diagnose liver fibrosis and cirrhosis

Israel's Ministry of Health approves Medgenics’ INFRADURE Phase I/II clinical trials for hepatitis C

ICUS applauds FDA's decision to modify U.S. product label for OPTISON ultrasound contrast agent

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Study reports new potential NOX inhibitor therapy for liver fibrosis

TAT-ARC fusion protein helps treat acute liver failure

Biomimetic bioartificial livers and cell toxicity assays: an interview with Dr. Joris Braspenning, CEO Medicyte

Hyperion Therapeutics announces completion of initial public offering

Gluconeogenesis severely compromised in HCC by IL6-Stat3-mediated activation of miR-23a

EASL calls on the UN to take action to fight against viral hepatitis infection

Hyperion prices initial public offering of 5,000,000 shares of common stock

Follow-up exams for patients with celiac disease are often inadequate and highly variable

EMA COMP issues positive opinion to Albireo for A4250

Aspirin use appears to reduce risk of Barrett's esophagus

Scientists identify inhibitors of key enzyme involved in survival of malaria parasite

HealthHIV, CCO announce new series of CME/CE-certified interactive local live workshops

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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