Immune System News and Research

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Researchers find CFI deficiency alarmingly high in old order Amish

Researchers from Children's Hospital of Philadelphia (CHOP) and the Clinic for Special Children found that complement factor I (CFI) deficiency, an ultra-rare genetic disorder that can cause debilitating neuroinflammation, is more than 4500 times more likely to be found in individuals of Old Order Amish ancestry than the rest of the global population.

13 Aug 2025

OU researchers explore how cannabis use affects recovery after head and neck cancer surgery

University of Oklahoma researchers are conducting a first-of-its-kind study to determine whether cannabis use affects recovery from the wounds associated with head and neck cancer surgery. The outcomes may have implications for other types of surgery and conditions.

12 Aug 2025

Polyphenols and exercise show promise in fighting gliomas

A new review in Food Science & Nutrition highlights how combining dietary polyphenols with structured exercise can enhance brain function, regulate epigenetics, and support glioma management. The authors outline mechanisms, patient-centered strategies, and research gaps for turning this synergy into clinical practice.

12 Aug 2025

Adding MET inhibitor enhances immune response against small cell lung tumors

Adding a MET gene inhibitor enhances the effect of combined chemotherapy and immunotherapy in small cell lung cancer (SCLC), according to a multicenter study led by the Hospital del Mar Research Institute, in collaboration with researchers from the CIBERONC cancer research network.

12 Aug 2025

Novel vaccine shows promise against KRAS-driven pancreatic and colorectal cancers

A novel cancer vaccine that stimulates the immune system to target one of the most common cancer-driving mutations has shown encouraging early results in patients with pancreatic and colorectal cancer, two of the most difficult-to-treat malignancies, according to a study led in part by investigators at the UCLA Health Jonsson Comprehensive Cancer Center.

12 Aug 2025

Global Virus Network committed to the continued development of mRNA vaccines

The Global Virus Network (GVN), a coalition of leading human and animal virologists from 80+ Centers of Excellence and Affiliates in more than 40 countries dedicated to advancing pandemic preparedness, is unequivocally committed to the continued development and deployment of mRNA vaccines and the global scientific collaboration that makes such innovation possible.

12 Aug 2025

Researchers develop machine learning models to identify biomarkers for chronic fatigue syndrome

When cells expire, they leave behind an activity log of sorts: RNA expelled into blood plasma that reveal changes in gene expression, cellular signaling, tissue injury and other biological processes.

11 Aug 2025

Breakthrough approaches enhance RNA delivery while minimizing inflammation

Lipid nanoparticles (LNPs) are tiny fat bubbles that are used to deliver medicines, genes, and RNA into cells. However, in some cases LNPs can cause harmful inflammation as a result of the process of RNA delivery.

11 Aug 2025

Implant system can treat Type 1 diabetes by supplying extra oxygen to insulin-secreting cells

Cornell researchers have developed an implant system that can treat Type 1 diabetes by supplying extra oxygen to densely packed insulin-secreting cells, without the need for immunosuppression.

11 Aug 2025

Parasitic worm evades detection by suppressing skin neurons

New research, published in The Journal of Immunology, discovered that a parasitic worm suppresses neurons in the skin to evade detection.

11 Aug 2025

How early immune challenges influence oral and systemic health in children

Once viewed only as infectious invaders, bacteria are now understood to play an important role in overall health.

8 Aug 2025

Decoding macrophage immune responses with gene editing and machine learning

Fighting off pathogens is a tour de force that must happen with speed and precision. A team of researchers at CeMM and MedUni Vienna led by Christoph Bock and Matthias Farlik has investigated how macrophages-immune cells that are the body's first responders-master this challenge.

8 Aug 2025

Understanding the biomarkers and mechanisms associated with anti-NMDAR encephalitis

Encephalitis is a potentially life-threatening condition that involves inflammation of the brain. While some cases of encephalitis are caused by a bacterial or viral infection, other cases of 'autoimmune' encephalitis result when the body's own immune system attacks the brain.

8 Aug 2025