Pathophysiology News and Research

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New study examines gender differences in prevalence and pathophysiology of COPD

A new study review authored by the University of Kentucky's Dr. David Mannino examines the gender differences in the prevalence, pathophysiology, and clinical presentation of chronic obstructive pulmonary disease (COPD) and how this information may ultimately be used to identify areas for future work.

4 Dec 2013

Cognitive behavioral therapy for PTSD affects underlying biology of the disorder

A new paper published in Biological Psychiatry suggests that cognitive behavioral therapy for posttraumatic stress disorder not only reduces symptoms but also affects the underlying biology of this disorder.

4 Dec 2013

3T MRI scanner allows Polish scientists to perform structural and functional imaging of human brain

The Nencki Institute of Experimental Biology in Warsaw launches research programs, which require state-of-the-art magnetic resonance scanner.

3 Dec 2013

Screening for genetic mutations may help identify silent carriers of adrenal Cushing's syndrome

Genetic research that will be published tomorrow in the New England Journal of Medicine suggests to Dr. André Lacroix, professor at the University of Montreal, that clinicians' understanding and treatment of a form of Cushing's syndrome affecting both adrenal glands will be fundamentally changed, and that moreover, it might be appropriate to begin screening for the genetic mutations that cause this form of the disease.

28 Nov 2013

Neuroimaging could predict psychosis treatment response

Assessing white matter integrity in patients with first-episode psychosis may predict who will respond to antipsychotic treatment, research suggests.

27 Nov 2013

Icahn School of Medicine receives $2.7M to investigate narrow pathway targeted immune therapy

The National Institutes of Health has awarded a research team at the Icahn School of Medicine at Mount Sinai $2.7 million to study systemic treatments for patients with moderate to severe atopic dermatitis (AD), also known as eczema.

26 Nov 2013

Enhancing the NMDA glutamate receptor causes antidepressant-like effects

Thirteen years ago, an article in this journal first reported that the anesthetic medication, ketamine, showed evidence of producing rapid antidepressant effects in depressed patients who had not responded to prior treatments. Ketamine works by blocking one of the targets for the neurotransmitter glutamate in the brain, the N-methyl-D-aspartate (NMDA) glutamate receptor.

20 Nov 2013

Elsevier launches two new open access journals in cardiology journals series

Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announced the launch of two new open access journals in its cardiology journals series: International Journal of Cardiology-Heart & Vessels and International Journal of Cardiology-Metabolic & Endocrine.

20 Nov 2013

Special issue on Helicobacter pylori provides new insights into diagnosis, prevention and treatment

A special issue on Helicobacter pylori has been published by Landes Bioscience (Austin, TX USA). The articles contained in this special issue of the journal Gut Microbes have been authored by world-class investigators and provide new insights into the pathophysiology, diagnosis, prevention, and treatment of this microbe.

20 Nov 2013

mTOR protein: A key mediator of antidepressant effects of ketamine

Two years ago, mammalian target of rapamycin or mTOR, a signaling protein, was identified as a key mediator of the antidepressant effects of ketamine, the first rapidly acting antidepressant medication to be identified.

20 Nov 2013

Grave prognosis for heart patients with treatment-resistant hypertension

Patients with coronary artery disease have a particularly high risk for poor outcomes if they have treatment-resistant hypertension, shows an analysis of the Treating to New Targets trial.

18 Nov 2013

European Commission grants marketing authorization for Bayer HealthCare's Xofigo injection

Bayer HealthCare announced today that the European Commission has granted marketing authorization for Xofigo (radium Ra 223 dichloride) solution for injection for the treatment of adults with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastases. This decision follows a positive recommendation from the European Committee for Medicinal Products for Human Use in September of this year.

15 Nov 2013

Brain & Behavior Research Foundation announces recipients of NARSAD Investigator Grants

The Brain & Behavior Research Foundation (formerly known as NARSAD, the National Alliance for Research on Schizophrenia and Depression), under the direction of Dr. Jeffrey Borenstein, President & CEO, has announced the latest recipients of its NARSAD Distinguished Investigator Grants.

8 Nov 2013

Advanced prostate cancer therapies: an interview with Dr. Nancy Dawson, Lombardi Comprehensive Cancer Center

The prostate gland produces part of the seminal fluid that protects sperm. It is located in front of the rectum and under the bladder, and surrounds the urethra, the tube through which urine flows from the bladder to and out of the penis.

6 Nov 2013

Endocrine Society announces winners of organization's prestigious 2014 Laureate Awards

The Endocrine Society today announced it has selected 15 accomplished endocrinologists as winners of the organization's prestigious 2014 Laureate Awards.

5 Nov 2013

Trophos completes efficacy study of olesoxime in patients with Spinal Muscular Atrophy

Trophos SA, a clinical stage pharmaceutical company developing innovative therapeutics from discovery to clinical validation for indications with under-served needs in neurology and cardiology, has completed its efficacy study of olesoxime in the rare neurodegenerative condition Spinal Muscular Atrophy.

5 Nov 2013

Offspring born to stressed mothers show stress-induced changes

Children of survivors of extremely stressful life events face adjustment challenges of their own, as has been most carefully studied among the children of Nazi Death Camp survivors. This "intergenerational" transmission of stress response has been studied predominately from the psychological perspective. However, recent research points to biological contributions as well.

5 Nov 2013

Oligomeric proanthocyanidin has protective effect on retinal ganglion cells, shows study

The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy. Oxidative stress is one of the major reasons to cause the cell death.

4 Nov 2013

Neuroimaging findings indicate presence of 'fatigue-network' in individuals with MS

A new study by Kessler Foundation scientists sheds light on the mechanisms underlying cognitive fatigue in individuals with multiple sclerosis. Cognitive fatigue is fatigue resulting from mental work rather than from physical labor.

4 Nov 2013

$IOF outlines guidelines to help prevent osteoporosis and fractures in cancer patients$

IOF outlines guidelines to help prevent osteoporosis and fractures in cancer patients

Cancer is a health burden of increasing importance which affects close to 13 million people globally. Bone is often affected in these patients, frequently because of bone metastases, or as a result of anti-cancer therapies which can contribute to bone loss and fragility.

4 Nov 2013

Pathophysiology News and Research

New study examines gender differences in prevalence and pathophysiology of COPD

Cognitive behavioral therapy for PTSD affects underlying biology of the disorder

3T MRI scanner allows Polish scientists to perform structural and functional imaging of human brain

Screening for genetic mutations may help identify silent carriers of adrenal Cushing's syndrome

Neuroimaging could predict psychosis treatment response

Icahn School of Medicine receives $2.7M to investigate narrow pathway targeted immune therapy

Enhancing the NMDA glutamate receptor causes antidepressant-like effects

Elsevier launches two new open access journals in cardiology journals series

Special issue on Helicobacter pylori provides new insights into diagnosis, prevention and treatment

mTOR protein: A key mediator of antidepressant effects of ketamine

Grave prognosis for heart patients with treatment-resistant hypertension

European Commission grants marketing authorization for Bayer HealthCare's Xofigo injection

Brain & Behavior Research Foundation announces recipients of NARSAD Investigator Grants

Advanced prostate cancer therapies: an interview with Dr. Nancy Dawson, Lombardi Comprehensive Cancer Center

Endocrine Society announces winners of organization's prestigious 2014 Laureate Awards

Trophos completes efficacy study of olesoxime in patients with Spinal Muscular Atrophy

Offspring born to stressed mothers show stress-induced changes

Oligomeric proanthocyanidin has protective effect on retinal ganglion cells, shows study

Neuroimaging findings indicate presence of 'fatigue-network' in individuals with MS

IOF outlines guidelines to help prevent osteoporosis and fractures in cancer patients

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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