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Hormone C-type natriuretic peptide protects the heart muscle from thickening abnormally

When the heart is weakened, it tries to compensate for its impaired pumping function through an enlargement of the heart muscle cells. Physicians speak in this case of cardiac hypertrophy, abnormal enlargement of the heart.

13 Mar 2006

Scientists create a mosquito resistant to Type 2 dengue fever virus

Researchers have successfully created a genetically engineered mosquito that shows a high level of resistance against the most prevalent type of dengue fever virus, providing a powerful weapon against a disease that infects 50 million people each year.

9 Mar 2006

Sex chromosome genes influence aggression

It has been well documented that, across human cultures and in most mammals, males are usually more aggressive and less nurturing than females.

9 Mar 2006

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Researchers at UC Irvine have found that a new compound not only relieves the cognitive symptoms of Alzheimer's disease, but also reduces the two types of brain lesions that are hallmarks of this devastating disease, thereby blocking its progression.

7 Mar 2006

Research shows promise for the advancement of cancer and stem-cell research

The paper explains how proteins, known as epigenetic activators (such as Ash1 from the fruit fly Drosophila), bind to their target DNA and activate genes that determine what function a cell will have in the body.

1 Mar 2006

Interleukin-15 encourages CD8+ T cells to proliferate and reduces their tolerance to tumor antigens

Certain types of white blood cells assist the body in destroying cancerous tumors. Among these are CD8+ T cells. The T is for thymus, the gland near the base of the throat that both raises up and weeds out blood cells involved in immune responses.

20 Feb 2006

Researchers create animal model of any schizophrenic characteristics

Researchers have developed a mouse strain in which the abnormal activity of the dopamine machinery in a specific part of the brain causes cognitive and behavioral impairments mimicking those in human schizophrenics.

20 Feb 2006

Cathepsin inhibitors as cancer therapies

In the March 1 issue, Drs. Johanna Joyce (MSKCC), Douglas Hanahan (UCSF) and colleagues lend new insight into how broad-spectrum cysteine cathepsin inhibitors combat pancreatic cancer, and provide new data to help refine the design of more precisely targeted anti-cathepsin therapies.

17 Feb 2006

Major Alzheimer's discovery

A team from the Faculty of Medicine at Universiti Laval and the research centre at CHUQ (Centre hospitalier universitaire de Quibec) has discovered a natural defence mechanism that the body deploys to combat nerve cell degeneration observed in persons with Alzheimer's disease (AD).

17 Feb 2006

Research sheds light on origins of "junk" DNA

In experiments with transgenic mice, University of Pennsylvania School of Medicine researchers discovered the remaining steps in the complicated process of how the largest class of jumping genes replicates and inserts themselves within the human genome.

7 Feb 2006

New tool for genetic research

In an article appearing online today in the journal Nature Methods, researchers at the EPFL (Ecole Polytechnique Fidirale de Lausanne) unveil a powerful new tool that will facilitate genetic research and open up new avenues for the clinical treatment of genetic disease.

23 Jan 2006

Histidine may be key to new therapies for cardiovascular disease

It's just one little amino acid, but it makes all the difference in protecting the heart from the harmful effects of heart attack and cardiac failure. Researchers from the University of Michigan Medical School suggest this amino acid, called histidine, could be the key to a new therapy for cardiovascular disease

23 Jan 2006

Identification of Gli protein degradation signals that directly affect tumor latency

Dr. Anthony E. Oro and colleagues (Stanford University) have identified two key Gli protein degradation signals that directly affect tumor latency in a mouse model of human skin cancer.

22 Jan 2006

Genome-wide prediction of mammalian enhancers for control of gene expression

Molecular biologists, developmental biologists and computer scientists at the Universtity of Helsinki, Finland, came together to advance towards cracking the code for how gene expression is controlled. The results of this work are published in Cell, in January 2006.

16 Jan 2006

Tobacco plant-derived vaccines safeguard against Yersinia pestis

Through an innovative feat of plant biotechnology and vaccine design, researchers in the Biodesign Institute at Arizona State University have successfully turned tobacco plants into vaccine production factories to combat the deadliest form

10 Jan 2006

Molecular link between high fat diets and type 2 diabetes established

Howard Hughes Medical Institute researchers have discovered a molecular link between a high-fat, Western-style diet, and the onset of type 2 diabetes. In studies in mice, the scientists showed that a high-fat diet disrupts insulin production, resulting in the classic signs of type 2 diabetes.

29 Dec 2005

Anti-Abeta42 and Anti-Abeta40–specific monoclonal antibodies attenuate amyloid deposition in an Alzheimer disease mouse model

Current hypotheses suggest that it is the accumulation over time of amyloid beta peptide 1–42 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease.

13 Dec 2005

Understanding obesity in humans

A new study by researchers at UT Southwestern Medical Center suggests that when fat cells increase in size - as they do during the development of obesity - the cells progressively lose receptors for the hormone leptin, a powerful stimulus for fat burning.

7 Dec 2005

Unexpected link between muscular dystrophy and muscle wasting associated with cancer

A new study provides important insight into the mechanisms of a muscle wasting disorder that interferes with treatment for cancer and has a negative impact on patient survival.

5 Dec 2005

Discovery of genetic mechanism that causes new arteries to grow in response to blocked arteries

Researchers at the San Francisco VA Medical Center have uncovered part of the genetic mechanism that causes new arteries to grow in response to blocked arteries.

2 Dec 2005