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Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Scientists have identified a lipid-degrading enzyme as a prognostic biomarker for luminal breast cancer.

31 May 2023

Study shows impacts of ASO-based MALAT1-inhibition on MAPK-pathway gene regulation in melanoma

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment."

30 May 2023

Novel technology enhances potency and breadth of vaccine-induced responses through antigen presentation

Novel EABR technology enhances potency and breadth of vaccine-induced responses through antigen presentation.

30 May 2023

Novel assay for identifying individuals with synucleinopathies using serum samples

Synucleinopathies are a group of neurodegenerative diseases caused by the abnormal accumulation α-synuclein, a protein normally found in the brain and neurons. Incorrect folding of α-synuclein leads to formation of 'seeds', which attract more α-synuclein proteins to form larger clumps.

29 May 2023

Novel endoscopic imaging system design could accelerate the adoption of multi-tracer FGS

For patients with solid cancers, endoscopic surgery is one of the primary treatment options to remove tumors. However, there is a high risk of cancer recurrence if even a small number of cancerous cells are left behind after surgical resection.

26 May 2023

Using nanoparticles and magnetic field to guide immunotherapy cells

A novel ideal proposed by European researchers would guide immunotherapy cells to where they are needed most.

26 May 2023

The potential clinical benefit of the Multabody platform as a therapeutic for SARS-CoV-2

The potential clinical benefit of the Multabody platform as a therapeutic for SARS-CoV-2.

26 May 2023

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Researchers develop a lipid nanoparticle-formulated mRNA-based antigen encoding three SARS-CoV-2 peptides derived from non-structural proteins.

25 May 2023

Bridging the Gap between Academia and Industry: The Power of Collaboration in Life Sciences

In this behind-the-scenes interview, we speak to Dr. Sinead Knight, chair of SLAS Europe 2023, about this years programme, highlighting the key topics and speakers.

From Society for Laboratory Automation and Screening (SLAS) 25 May 2023

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

Abdominal obesity increases the risk of severe COVID-19 and mortality due to heightened inflammatory responses, according to a study on Japanese patients and a murine COVID-19 model. Blocking inflammatory cytokines and preventing obesity may improve survival rates.

24 May 2023

Gut check: Our microbiome's vitamin factory could redefine personal health

Research highlights the crucial role of vitamins in metabolic and regulatory processes. It explores the microbial contribution of essential vitamins, such as vitamin K and B-group vitamins, in the gastrointestinal tract, emphasizing their impact on human health and the gut microbiome.

23 May 2023

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

A new research paper was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis."

23 May 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Research introduces FeLab, a responsive hydrogel that combines nanozymes and probiotics for the treatment of Candida vaginitis. FeLab demonstrates effective anti-Candida activity, promotes vaginal mucosa repair, and restores healthy vaginal microbiota, offering a promising therapeutic approach for this condition.

21 May 2023

Indirect inhibitors of cellular respiration for treatment of glioblastoma

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Targeting cellular respiration as a therapeutic strategy in glioblastoma."

19 May 2023

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

Alzheimer's Disease (AD) is a complex neurodegenerative illness with genetic and environmental origins.

19 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Both vaccine strain and adjuvant selection are critical elements for improving the breadth of protective immunity against enterovirus D68

Researchers demonstrated the production of cross-clade neutralizing antibodies in response to EV-D68.

19 May 2023

Turn down the heat: Spicy foods linked to memory decline in inactive seniors

Research investigates the association between spicy food consumption and Alzheimer's disease (AD) or cognitive decline in older adults. The study found that a high level of spiciness in food is associated with decreased memory or global cognition, and this relationship is worsened by a physically inactive lifestyle.

18 May 2023

in vivo News and Research

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Study shows impacts of ASO-based MALAT1-inhibition on MAPK-pathway gene regulation in melanoma

Novel technology enhances potency and breadth of vaccine-induced responses through antigen presentation

Novel assay for identifying individuals with synucleinopathies using serum samples

Novel endoscopic imaging system design could accelerate the adoption of multi-tracer FGS

Using nanoparticles and magnetic field to guide immunotherapy cells

The potential clinical benefit of the Multabody platform as a therapeutic for SARS-CoV-2

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Bridging the Gap between Academia and Industry: The Power of Collaboration in Life Sciences

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

Gut check: Our microbiome's vitamin factory could redefine personal health

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Surviving without glucose: uridine-derived ribose as an alternative energy source

Hydrogel combines nanozymes and probiotics for effective Candida vaginitis treatment

Indirect inhibitors of cellular respiration for treatment of glioblastoma

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Both vaccine strain and adjuvant selection are critical elements for improving the breadth of protective immunity against enterovirus D68

Turn down the heat: Spicy foods linked to memory decline in inactive seniors

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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