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Inotuzumab ozogamicin achieves over 50% response rate against acute lymphoblastic leukemia

An antibody packaged with a potent chemotherapy drug to selectively destroy acute lymphoblastic leukemia (ALL) cells eradicated or greatly reduced the disease for 61 percent of 46 patients in a phase II study. It will be presented at the 47th annual meeting of the American Society of Clinical Oncology in Chicago June 3-7.

24 May 2011

Mount Sinai researchers identify protein signaling hyperactivity in human sarcoma cells

Researchers from Mount Sinai School of Medicine have discovered a protein signaling pathway that becomes hyperactivated in human sarcoma cells, suggesting that medications to inhibit this pathway may be effective in the treatment of human sarcomas. The research is published in the current issue of the journal Cancer Cell.

24 May 2011

'Survival protein' protects brain against effects of stroke

Johns Hopkins scientists say that a newly discovered "survival protein" protects the brain against the effects of stroke in rodent brain tissue by interfering with a particular kind of cell death that's also implicated in complications from diabetes and heart attack.

24 May 2011

PolyPid announces new drug delivery system and an innovative biodegradable bone void filler

PolyPid, a developer of innovative drug carriers, announced today the company’s flagship platform – PolyPid. PolyPid is a new, innovative family of drug carriers, based on a fusion between two known drug delivery systems: polymers and lipid-based systems. The new drug carriers enable long-lasting and controlled release of therapeutic drugs. The revolutionary, patented carrier can be tailored to almost any drug – small molecules, peptides, protein and nucleic acids-based drugs. The formulations can be pre-planned in order to achieve the desired release rate of the drug/s and the optimal duration, which can last up to several months.

23 May 2011

Discovery of possible new strategy for treating neurologic disorders

23 May 2011

An alternative solid phase affinity matrix for chromatin immunoprecipitation

Porvair Filtration Group working in collaboration with the Department of Biological Sciences, University of Essex, UK has produced an alternative, high performance Solid Phase Affinity Matrix for Chromatin Immunoprecipitation (ChIP) assays. The research at Essex University evaluating the new BioVyon - Protein A material in ChIP assays is published in the May 2011 issue of Analytical Biochemistry.

From Chromatrap® - Porvair Sciences Ltd 23 May 2011

Scientists find new drug target in breast cancer

Researchers have identified a new protein involved in the development of drug resistance in breast cancer which could be a target for new treatments, they report today in the journal Nature Medicine.

23 May 2011

Sangamo announces presentations of ZFP Therapeutics data at ASGCT 2011

Sangamo BioSciences, Inc. announced today that data from clinical, preclinical and research-stage programs focused on the development of zinc finger DNA-binding protein Therapeutics were described in twenty presentations given by Sangamo scientists and collaborators at the 14th Annual Meeting of the American Society of Gene and Cell Therapy.

23 May 2011

Lund University researcher discovers new sepsis biomarker in blood

Sepsis is the name of an infection that causes a series of reactions in the body, which in the worst case can prove fatal. The problem for both patients and doctors is that the early symptoms are difficult to distinguish from less dangerous infections such as a severe flu or winter vomiting disease.

23 May 2011

Tumor necrosis factor can suppress inflammation, treat rheumatoid arthritis

A new study by rheumatologists at Hospital for Special Surgery in New York has shown that a powerful pro-inflammatory protein, tumor necrosis factor, can also suppress aspects of inflammation.

23 May 2011

Researchers identify new drug resistant protein in breast cancer

Researchers have identified a new protein involved in the development of drug resistance in breast cancer which could be a target for new treatments, they report today in the journal Nature Medicine.

23 May 2011

Salk researchers successfully edit diseased gene in patient-specific induced pluripotent stem cells

In principle, genetic engineering is simple, but in practice, replacing a faulty gene with a healthy copy is anything but. Using mutated versions of the lamin A gene as an example to demonstrate the versatility of their virus-based approach, researchers at the Salk Institute for Biological Studies successfully edited a diseased gene in patient-specific induced pluripotent stem cells as well as adult stem cells.

21 May 2011

Lilly Phase I multiple myeloma study affirms potential of LY2127399-bortezomib combination

Eli Lilly and Company announced Phase I data on LY2127399, a human monoclonal antibody that neutralizes B-cell activating factor (BAFF), for use in combination with bortezomib in patients with previously-treated multiple myeloma.

21 May 2011

Modified cells protect marrow and blood cells from harmful chemotherapy effects in brain tumor patients

Although chemotherapy is used to kill cancer cells, it can also have a strong toxic effect on normal cells such as bone marrow and blood cells, often limiting the ability to use and manage the chemotherapy treatment.

21 May 2011

DFG to fund 60 million euros for 18 new Research Training Groups

With the aim of further strengthening early-career research in Germany, the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is to establish 18 new Research Training Groups.

21 May 2011

Researchers develop cheap, reliable diagnostic test for HLRCC

Researchers at the University of Oxford have developed a cheap and reliable diagnostic test for a rare form of cancer. The test involves screening tumour samples for a particular molecular fingerprint unique to this type of cancer.

21 May 2011

Stopping prostate cancer cells from 'bulking up' with nutrients blocks spread of disease

Cancer Research UK scientists have discovered that stopping prostate cancer cells from 'bulking up' with nutrients reduces the spread of the disease and tumour size, according to research published today in EMBO Journal.

21 May 2011

Healthy breakfast containing protein-rich foods can help people stay satisfied longer

A University of Missouri researcher has found that eating a healthy breakfast, especially one high in protein, increases satiety and reduces hunger throughout the day. In addition, using functional magnetic resonance imaging (fMRI) the researchers found that eating a protein-rich breakfast reduces the brain signals controlling food motivation and reward-driven eating behavior.

20 May 2011

Curcumin compound can help head and neck cancer cells overcome resistance to chemotherapy drugs

A primary reason that head and neck cancer treatments fail is the tumor cells become resistant to chemotherapy drugs. Now, researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from the Indian spice curcumin can help cells overcome that resistance.

20 May 2011

Berkeley Lab scientists reveal how protein-making machine bends without breaking

It sounds like hype from a late-night infomercial: It can twist and bend without breaking! And wait, there's more: It could someday help you fend off disease!

20 May 2011

G Protein News and Research

Inotuzumab ozogamicin achieves over 50% response rate against acute lymphoblastic leukemia

Mount Sinai researchers identify protein signaling hyperactivity in human sarcoma cells

'Survival protein' protects brain against effects of stroke

PolyPid announces new drug delivery system and an innovative biodegradable bone void filler

Discovery of possible new strategy for treating neurologic disorders

An alternative solid phase affinity matrix for chromatin immunoprecipitation

Scientists find new drug target in breast cancer

Sangamo announces presentations of ZFP Therapeutics data at ASGCT 2011

Lund University researcher discovers new sepsis biomarker in blood

Tumor necrosis factor can suppress inflammation, treat rheumatoid arthritis

Researchers identify new drug resistant protein in breast cancer

Salk researchers successfully edit diseased gene in patient-specific induced pluripotent stem cells

Lilly Phase I multiple myeloma study affirms potential of LY2127399-bortezomib combination

Modified cells protect marrow and blood cells from harmful chemotherapy effects in brain tumor patients

DFG to fund 60 million euros for 18 new Research Training Groups

Researchers develop cheap, reliable diagnostic test for HLRCC

Stopping prostate cancer cells from 'bulking up' with nutrients blocks spread of disease

Healthy breakfast containing protein-rich foods can help people stay satisfied longer

Curcumin compound can help head and neck cancer cells overcome resistance to chemotherapy drugs

Berkeley Lab scientists reveal how protein-making machine bends without breaking

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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