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Deficiencies in DNA loop formation can cause multiple diseases: Research

The genes that are responsible for maintaining each cell type form DNA loops that link control elements for these genes. This surprising genome structure is generated and reinforced by two essential protein complexes that bridge the loops and contribute to proper gene regulation.

19 Aug 2010

MD Anderson Cancer Center receives $20 million to advance research on targeted therapies

Dallas businessman and philanthropist H. Ross Perot has donated $20 million to The University of Texas MD Anderson Cancer Center for research to advance and design novel targeted therapies.

19 Aug 2010

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Researchers at Massachusetts General Hospital found that patients with nonalcoholic fatty liver disease (NAFLD) who carry an allele of the PNPLA3 gene have an increased risk of developing advanced disease, including nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. A second study supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) validates these findings and further concludes that in pediatric patients, the same allele is associated with earlier disease presentation.

18 Aug 2010

Advanced Cell Technology to obtain patent for cellular reprogramming, generation of iPS cells

Advanced Cell Technology, Inc. announced today that it is positioned to obtain significant patents relating to cellular reprogramming and the generation of induced pluripotent stem (iPS) cells. iPS cells are similar to embryonic stem (ES) cells, except they are generated from adult cells such as skin using certain reprogramming factors, without the controversial use of embryos. Although human iPS cells were first produced in 2007, ACT has been working on inducing pluripotency, with positive results, for more than a decade. The Company's efforts go back to the 1990s, providing (through existing patent filings and continuations) some of the earliest priority dates in the field.

18 Aug 2010

UK scientists receive Royal Society awards for cancer research

Two Cancer Research UK scientists were recently awarded prestigious Royal Society Awards, while a number of Cancer Research UK scientists were elected fellows of the Royal Society and the Academy of Medical Sciences.Dr Tomas Lindahl is the recipient of the Royal Society Copley Medal, the world's oldest prize for scientific achievement, and Professor Stephen West is awarded this year's GlaxoSmithKline Prize and Lecture.

18 Aug 2010

Research confirms genetic link to advanced fatty liver disease

17 Aug 2010

Chronix Biomedical expands biomarker development capabilities with installation of DNA mass sequencer

Chronix Biomedical today reported that it has significantly expanded and accelerated its biomarker development capabilities with the installation of Germany's first state-of-the-art high-throughput DNA mass sequencer at the University of Göttingen, Chronix's long-time collaborator. Chronix is developing disease-specific biomarkers based on DNA fragments that are released into the bloodstream by damaged and dying (apoptotic) cells.

17 Aug 2010

Scientists identify possible therapeutic strategy for reducing leukemia risk from chemotherapy

A UCSF-led team has discovered at least one key reason why blood stem cells are susceptible to developing the genetic mutations that can lead to adult leukemia. Their finding also may explain, they say, why some other age-related hematological disorders develop.The study, reported in "Cell Stem Cell" and reviewed in Cell Stem Cell and Cell, opens a new frontier for studying the molecular underpinnings of adult leukemia.

17 Aug 2010

Scientists find epigenetic landscape map for tissue differentiation

Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation.The details of this collaborative study between Johns Hopkins, Stanford and Harvard appear August 15 in the early online publication of Nature.

17 Aug 2010

Albert Einstein College of Medicine named 1 of 5 Nathan Shock Centers

Albert Einstein College of Medicine of Yeshiva University has been named one of the National Institutes of Health's (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. The select group of five centers nationwide provides leadership in the pursuit of basic research into the biology of aging. Einstein's designation includes a $3.1 million, five-year grant from the NIH's National Institute on Aging.

17 Aug 2010

Arrayit announces addition of 128 new products to life sciences tools portfolio

Arrayit Corporation, a leader in life sciences and healthcare technology, announces today that the company has added 128 new products to its widely-used portfolio of life sciences tools. Arrayit now offers 836 life sciences products to researchers worldwide, all of which can be purchased on-line 24 hours a day at the Arrayit Store. The company has recorded $36.2M in product revenue in the Arrayit Store since its inception.

16 Aug 2010

Abnormalities in certain genes may cause autism: Research

Together with colleagues from an international research group, autism researcher Christopher Gillberg of the University of Gothenburg, Sweden, has found in a new study that autism can be partially explained by abnormalities in certain genes. The group's results could, in the long run, pave the way for more appropriate treatments for autism.

16 Aug 2010

Researchers discover genetic alterations responsible for Kabuki syndrome

Using a new, rapid and less expensive DNA sequencing strategy, scientists have discovered genetic alterations that account for most cases of Kabuki syndrome, a rare disorder that causes multiple birth defects and mental retardation. Instead of sequencing the entire human genome, the new approach sequences just the exome, the 1-2 percent of the human genome that contains protein-coding genes.

16 Aug 2010

CLC bio, PSSC Labs announce new turnkey solution for full-genome assembly and analysis

Today, CLC bio and PSSC Labs announced a new turnkey solution, CLC Genomics Factory, for assembly, read mapping, and subsequent downstream analysis of very large amounts of high-throughput DNA and RNA sequencing data. Built as a high-performance bioinformatics appliance, CLC Genomics Factory comes in three different sizes with varying numbers of compute nodes, capable of processing the data output from up to 10 Illumina HiSeq2000 or 7 Life Technologies SOLiD 4 systems.

13 Aug 2010

Researchers find transposons determine differences in physical traits, disease risks

Building on a tool that they developed in yeast four years ago, researchers at the Johns Hopkins University School of Medicine scanned the human genome and discovered what they believe is the reason people have such a variety of physical traits and disease risks.

12 Aug 2010

Sage Science introduces Pippin Prep DNA size selection system in US markets

Sage Science, Inc. announced today the release of the Pippin Prep DNA size selection system to the United States market. This device automates the collection of DNA fragments for next generation sequencing library preparations, and replaces manual gel purification techniques that typically require hours of effort.

12 Aug 2010

Systemic lupus erythematosus drug market to quadruple from $400 million in 2009 to over $1.6 billion in 2019

Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, driven primarily by the launch and uptake of Human Genome Sciences/GlaxoSmithKline's Benlysta, the systemic lupus erythematosus (SLE) drug market will quadruple from about $400 million in 2009 to more than $1.6 billion in 2019 in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan.

10 Aug 2010

Genetic factors lead to meningitis development: Study

Genetic differences that make some people susceptible to developing meningococcal meningitis and septicaemia, and others naturally immune, are revealed in a new study of over 6,000 people, published today in Nature Genetics.The research, led by Imperial College London and the Genome Institute of Singapore, is the largest ever genetic study of meningitis and septicaemia caused by meningococcal bacteria. It suggests that people who develop these diseases have innate differences in their natural defences that leave them unable to attack meningococcal bacteria successfully.

9 Aug 2010

GWA Study helps scientists identify genetic variant that increases tuberculosis susceptibility in African populations

Scientists have identified a genetic variant which increases susceptibility to tuberculosis (TB) in African populations using a technique known as a genome-wide association (GWA) study. This is the first novel disease variant to be identified using this technique in Africans and demonstrates that such studies are viable in African populations, which have a high degree of genetic diversity.

9 Aug 2010

UCSF researchers discover new technology purifying special types of stem cells

UCSF researchers are reporting the first success in very rapidly purifying one type of embryonic stem cell from a mix of many different types of embryonic stem cells in the culture dish. The technique, which avoids the need to genetically alter the cells to distinguish them, is a key advance, the researchers say, for obtaining the appropriate cells for repairing specific damaged tissues.

7 Aug 2010

Genome News and Research

Deficiencies in DNA loop formation can cause multiple diseases: Research

MD Anderson Cancer Center receives $20 million to advance research on targeted therapies

Genome-wide study identifies key genetic variant associated with nonalcoholic fatty liver disease

Advanced Cell Technology to obtain patent for cellular reprogramming, generation of iPS cells

UK scientists receive Royal Society awards for cancer research

Research confirms genetic link to advanced fatty liver disease

Chronix Biomedical expands biomarker development capabilities with installation of DNA mass sequencer

Scientists identify possible therapeutic strategy for reducing leukemia risk from chemotherapy

Scientists find epigenetic landscape map for tissue differentiation

Albert Einstein College of Medicine named 1 of 5 Nathan Shock Centers

Arrayit announces addition of 128 new products to life sciences tools portfolio

Abnormalities in certain genes may cause autism: Research

Researchers discover genetic alterations responsible for Kabuki syndrome

CLC bio, PSSC Labs announce new turnkey solution for full-genome assembly and analysis

Researchers find transposons determine differences in physical traits, disease risks

Sage Science introduces Pippin Prep DNA size selection system in US markets

Systemic lupus erythematosus drug market to quadruple from $400 million in 2009 to over $1.6 billion in 2019

Genetic factors lead to meningitis development: Study

GWA Study helps scientists identify genetic variant that increases tuberculosis susceptibility in African populations

UCSF researchers discover new technology purifying special types of stem cells

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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