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Scientists identify role of PNPASE in regulating RNA import into mitochondria

Researchers at UCLA's Jonsson Comprehensive Cancer Center and the departments of Chemistry and Biochemistry and Pathology and Laboratory Medicine have uncovered a role for an essential cell protein in shuttling RNA into the mitochondria, the energy-producing "power plant" of the cell. The import of nucleus-encoded small RNAs into mitochondria is essential for the replication, transcription and translation of the mitochondrial genome, but the mechanisms that deliver RNA into mitochondria remain poorly understood.

7 Aug 2010

Alnylam publishes research findings of Sort1 gene role in cardiovascular disease development

Alnylam Pharmaceuticals, Inc. a leading RNAi therapeutics company, announced today the publication of new research findings in the journal Nature describing the discovery and validation of the role of the gene Sort1 in the development of cardiovascular disease, including myocardial infarction (MI). This work was done with collaborators at University of Pennsylvania (UPenn) School of Medicine, Massachusetts General Hospital (MGH), and the Broad Institute. The collaborative effort combined genome-wide association studies (GWAS) and RNAi technology to identify and validate novel genes as targets for new therapies for heart disease.

6 Aug 2010

Helmsley Charitable Trust awards $3.15M grant to support UofL James Graham Brown Cancer Center

The University of Louisville has received a $3.15 million grant from the Leona M. and Harry B. Helmsley Charitable Trust to support the UofL James Graham Brown Cancer Center and cancer research taking place in Owensboro. The grant will be matched with state "Bucks for Brains" funding to bring more than $4.5 million to the Owensboro Cancer Research Program.

6 Aug 2010

Scientists identify genetic variant that increases risk of schizophrenia

A group of scientists has identified a genetic variant that substantially increases the risk for developing schizophrenia in Ashkenazi Jewish and other populations. The study, published by Cell Press on August 5th in the American Journal of Human Genetics, associates a deletion on chromosome 3 with increased incidence of schizophrenia.

6 Aug 2010

Researchers identify gene associated with susceptibility to chronic pain caused by nerve injury

Researchers at the Hebrew University of Jerusalem and elsewhere have succeeded in identifying for the first time a gene associated with susceptibility to chronic pain caused by nerve injury in humans, signaling a significant step toward better understanding and treating of the condition.

6 Aug 2010

Agendia inaugurates new clinical genomics laboratory

Agendia, a world leader in molecular cancer diagnostics, today announced the inauguration of a new state-of-the-art clinical genomics laboratory in Irvine, CA. Previously, Agendia's offices and laboratory were located in Huntington Beach, CA. The new laboratory will further increase capacity to support Agendia's strong commercial expansion in the U.S. market, as well as the use of multiple Agendia tests in clinical research. MammaPrint, the company's lead product and the only FDA-cleared breast cancer recurrence test, is reimbursed by an increasing number of payers, covering some 100 million lives today.

6 Aug 2010

Life Technologies, UCSD Moores Cancer Center to use SOLiD 4 technology to study CLL

Life Technologies Corporation and the University of California at San Diego Moores Cancer Center today announced a partnership to use SOLiD 4 genomic analysis technology in a research program to study chronic lymphocytic leukemia, a cancer of the white blood cells. The CLL research is made possible by funding from the National Institutes of Health and will enable scientists to survey the whole transcriptomes of 96 CLL tumor samples for potential biomarkers.

5 Aug 2010

German Virtual Liver Network aims to grasp whole organ and functions in computer model

The aim of this unique research consortium is to grasp the whole organ and its functions in a computer model

5 Aug 2010

Gene associated with susceptibility to chronic pain caused by nerve injury identified

Researchers at the Hebrew University of Jerusalem and elsewhere have succeeded in identifying for the first time a gene associated with susceptibility to chronic pain caused by nerve injury in humans, signalling a significant step toward better understanding and treating of the condition.

5 Aug 2010

Genomic sequence of living marine sponge reveals some basic information about cancer: Scientists

This week's publication of the complete genomic sequence of a living marine sponge reveals genes dating back hundreds of millions of years -- a result far exceeding the expectations of the scientific world.

5 Aug 2010

SORT1 pathway holds promise as new target for therapeutic intervention for LDL cholesterol reduction

The true power of genomic research lies in its ability to help scientists understand biological processes, particularly those that - when altered - can lead to disease. This power is demonstrated dramatically in a pair of papers published today in the journal Nature. In the first, a global team of researchers describes 95 different variations across the genome that contribute in different degrees to alterations in blood cholesterol and triglyceride levels in multiple human populations. In the second report, close examination of just one of these common variants not only reveals the involvement of an unexpected genetic pathway in lipid metabolism but also provides a blueprint for using genomic findings to unravel biological connections between lipid levels and coronary heart disease.

5 Aug 2010

Study links sea sponge genome sequence with first animals and cancer

The sponge, which was not recognized as an animal until the 19th century, is now the simplest and most ancient group of animals to have their genome sequenced. In a paper appearing in the August 5 issue of the journal Nature, a team of researchers led by Daniel Rokhsar of the University of California, Berkeley, and the Department of Energy's Joint Genome Institute (JGI), report the draft genome sequence of the sea sponge Amphimedon queenslandica and several insights the genome gives into the origins of both the first animals and cancer.

5 Aug 2010

Scientists identify 95 gene loci that influence lipoprotein metabolism in humans

In a large-scale international study in which Helmholtz Zentrum München participated, scientists have identified 95 gene loci which influence lipoprotein metabolism in humans. Viewed from a long-term perspective, these findings open up new lines of research in the prevention and treatment of coronary artery disease. It is the first genome-wide association study of this kind to be published in the prestigious journal Nature.

4 Aug 2010

QCMG selects SGI LiveArc storage solution for cancer genome sequence data processing

SGI, a global leader in HPC and data center solutions, today announced that the Queensland Centre for Medical Genomics at the University of Queensland has selected SGI LiveArc storage solution to increase its ability to store, manage and process human cancer genome sequence data. This project will contribute to mapping the genetic changes that lead to cancer, providing better understanding of such cancers and potentially helping to combat the disease.

4 Aug 2010

BCM collaborates with Roche NimbleGen for high throughput exome capture technology

The Baylor College of Medicine Human Genome Sequencing Center has standardized its target enrichment human disease research studies on Roche NimbleGen Sequence Capture Exome technology. The Baylor HGSC will sequence over 5,000 exomes in the next two years to identify genetic variants underlying multiple human diseases and will employ NimbleGen SeqCap EZ Exome and customized NimbleGen exome designs as the exome capture technology of choice. More than 15 different diseases will be investigated by Baylor HGSC, including brain, liver, pancreatic, colon, ovarian and bladder cancers, heart disease, diabetes, autism, and other inherited diseases with the goal of better understanding causative mutations and their impact on these diseases.

4 Aug 2010

Caliper Life Sciences second-quarter GAAP revenue decreases 10% to $29.0 million

Caliper Life Sciences, Inc., today reported results for its second quarter ended June 30, 2010. Second quarter GAAP revenue decreased 10% to $29.0 million from $32.1 million in the same period in 2009 as a result of divestitures in 2010 and 2009. Revenue from on-going business increased 4% on a reported basis and 6% on an organic basis (which assumes constant currency).

3 Aug 2010

Emerging Healthcare Solutions executes Term Sheet with Stand-By Systems

Emerging Healthcare Solutions, Inc. disclosed today that the Company has executed a Term Sheet with Stand-By Systems. The Term Sheet represents successful negotiations between the two companies just ahead of finalizing a Definitive Agreement. Stand-By Systems (SBS) owns the FDA approved SBS 1615 catalytic oxygen generator and associated systems. This cutting edge generator provides medical grade USP oxygen at the push of a button from self-contained inert dry compounds.

3 Aug 2010

People insensitive to quinine's bitter taste may have varied absorption, metabolization capabilities: Study

Some people find quinine to be bitter while others can drink it like water. Now, scientists from the Monell Center and collaborators report that individual differences in how people experience quinine's bitterness are related to underlying differences in their genes.The findings, published online in the journal Human Molecular Genetics, demonstrate that genetic variation in regions of DNA that encode bitter taste receptors predicts a person's perception of bitterness from quinine.

3 Aug 2010

Researchers develop techniques to identify evolution of drug resistance strains of malaria

Researchers at Case Western Reserve University developed techniques to quickly identify evolution of drug resistance in strains of malaria. Their goal is to enable the medical community to react quickly to inevitable resistance and thereby save lives while increasing the lifespan of drugs used against the disease.Currently, disease monitoring requires months of clinical trials. The new methods can provide more information in just days, and far cheaper.

3 Aug 2010

Scientists identify genetic basis for prostate cancer susceptibility in non-European population

A genome-wide study on Japanese subjects has identified 5 new genetic variations associated with prostate cancer and revealed differences and similarities between Europeans and Asians in susceptibility to the disease. Reported in Nature Genetics, the findings offer a first-ever glimpse of the genetic basis for prostate cancer susceptibility in a non-European population.

2 Aug 2010

Genome News and Research

Scientists identify role of PNPASE in regulating RNA import into mitochondria

Alnylam publishes research findings of Sort1 gene role in cardiovascular disease development

Helmsley Charitable Trust awards $3.15M grant to support UofL James Graham Brown Cancer Center

Scientists identify genetic variant that increases risk of schizophrenia

Researchers identify gene associated with susceptibility to chronic pain caused by nerve injury

Agendia inaugurates new clinical genomics laboratory

Life Technologies, UCSD Moores Cancer Center to use SOLiD 4 technology to study CLL

German Virtual Liver Network aims to grasp whole organ and functions in computer model

Gene associated with susceptibility to chronic pain caused by nerve injury identified

Genomic sequence of living marine sponge reveals some basic information about cancer: Scientists

SORT1 pathway holds promise as new target for therapeutic intervention for LDL cholesterol reduction

Study links sea sponge genome sequence with first animals and cancer

Scientists identify 95 gene loci that influence lipoprotein metabolism in humans

QCMG selects SGI LiveArc storage solution for cancer genome sequence data processing

BCM collaborates with Roche NimbleGen for high throughput exome capture technology

Caliper Life Sciences second-quarter GAAP revenue decreases 10% to $29.0 million

Emerging Healthcare Solutions executes Term Sheet with Stand-By Systems

People insensitive to quinine's bitter taste may have varied absorption, metabolization capabilities: Study

Researchers develop techniques to identify evolution of drug resistance strains of malaria

Scientists identify genetic basis for prostate cancer susceptibility in non-European population

Genetics & Genomics - Second Edition eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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