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'Senolytic' therapy blunts liver tumor progression in animal models

"Senotherapy," a treatment that uses small molecule drugs to target "senescent" cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, Ph.D., a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute.

20 May 2020

Study: Bioelectrical view can provide biological understanding of cellular processes

We use cells to breathe, to moderate body temperature, to grow and many other every day processes, however the cells in these processes are so complex its left scientists perplexed into how they develop in different environments.

20 May 2020

New study initiated to establish the presence of SARS-CoV-2 in environmental samples

he Ministry of Science and Innovation, by way of the COVID-19 fund of the Carlos III Health Institute (ISCIII), is funding a study aimed at establishing the presence of SARS-CoV-2 in environmental samples as well as its indirect transmission potential.

20 May 2020

Immunologists propose possible molecular mechanism for the deadly respiratory syndrome

Research into how the SARS-CoV-2 virus induces death is suggesting potential treatments for its most destructive complications.

20 May 2020

Family environment and socioeconomic status affect brain development during adolescence

Childhood environment and socioeconomic status affect cognitive ability and brain development during adolescence independently of genetic factors, researchers at Karolinska Institutet report in a new study published in the journal PNAS.

20 May 2020

Children exposed to maternal antenatal corticosteroids have more behavioral disorders

Maternal antenatal corticosteroid treatment is standard care when there is a risk for preterm delivery. The treatment improves the prognosis of babies born preterm.

20 May 2020

Diagnosis and treatment of nonalcoholic fatty liver disease

Gastroenterology, the official journal of the American Gastroenterological Association (AGA), has released a special issue providing clinicians and researchers an up-to-date resource on the risk factors, natural history, diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD).

20 May 2020

Methodologies to detect the presence of SARS-CoV-2

In an important, comprehensive, and timely review, an expert team from the University of California Berkeley details the methodologies used in nucleic acid-based tests for detecting the presence of SARS-CoV-2, the virus that causes COVID-19.

20 May 2020

Study could help identify more targeted treatments for ovarian cancer

The rogue cellular engine that drives a majority of ovarian cancers remains frustratingly difficult to disable. A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about this machinery and confirms biological hallmarks of survival.

20 May 2020

MU researchers examine how menopause can impact cognitive function

Characterized by a buildup of amyloid plaques in the brain, Alzheimer's is an irreversible disease that leads to memory loss and a decrease in cognitive function.

19 May 2020

Texas A&M lab produces 3D-bioprinted bone tissue to benefit bone regeneration

Dr. Akhilesh K. Gaharwar, associate professor, has developed a highly printable bioink as a platform to generate anatomical-scale functional tissues. This study was recently published in the American Chemical Society's Applied Materials and Interfaces.

19 May 2020

Do parasites protect against SARS-CoV-2?

The world has rarely seen such a readily transmissible infection as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over the last century. Within five months, the virus has created a Tsunami of COVID-19 positive cases, comprising almost 4.88 million people and causing 322,000 deaths.

19 May 2020

Gene mutation linked to MEF2C haploinsufficiency syndrome

A collaboration between scientists at the Medical University of South Carolina and clinicians at the Greenwood Genetic Center has yielded new findings about how a particular gene might regulate brain development.

19 May 2020

Did SARS-CoV-2 adapt to humans long before the index case?

A new study from Canada and the U.S. suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have already been pre-adapted to human transmission when it emerged in late 2019, which means there may be lingering populations of progenitor SARS-CoV-2 adept for human transmission and coronavirus disease (COVID-19) re-emergence. The research is published on the preprint server bioRxiv in May 2020.

19 May 2020

DZD researchers discover additional genetic cause for non-alcoholic fatty liver disease

In Germany about 18 million people suffer from non-alcoholic fatty liver. The causes of this disease are manifold and include environmental as well as genetic factors.

19 May 2020

Gene variants can increase risk of schizophrenia, shows study

Variants in a gene of the human immune system cause men and women to have different vulnerabilities to the autoimmune diseases lupus and Sjögren's syndrome, according to findings published in the journal Nature.

19 May 2020

Study: Personalized ovarian cancer risk prediction reduces worries among a majority of women

Offering personalised ovarian cancer risk prediction to women shows that 98 per cent of participants felt less worried after finding out their ovarian cancer risk status, according to a study led by Queen Mary University of London.

19 May 2020

Mount Sinai researchers are first to use AI model to analyze COVID-19 patients

Mount Sinai researchers are the first in the country to use artificial intelligence (AI) combined with imaging, and clinical data to analyze patients with coronavirus disease (COVID-19).

19 May 2020

Study shows how normal RAS interacts with mutated RAS in living cells

Many cancer medications fail to effectively target the most commonly mutated cancer genes in humans, called RAS.

19 May 2020

New animal model for COVID-19

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to ravage the world, scientists are frantically searching for a vaccine or new drug that will effectively counter the lethal effects of the virus that leads to COVID-19 disease.

19 May 2020