Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Researchers develop new way to fight late-stage sepsis

Researchers have developed a way to prop up a struggling immune system to enable its fight against sepsis, a deadly condition resulting from the body's extreme reaction to infection.

6 Jan 2020

Aspirin’s benefits may extend beyond heart health to colorectal cancer treatment

The benefits of a daily aspirin may extend beyond heart health to colorectal cancer treatment, say City of Hope researchers who have found aspirin appears to reduce tumor growth and inhibit recurrence of the disease.

6 Jan 2020

Researchers move closer to identifying leukemic stem cells

Acute myeloid leukemia is the most common type of leukemia in adults. It is characterized by the pathological expansion of immature cells (myeloblasts) that invade the bone marrow and expand into the blood, affecting the production of the rest of the healthy cells.

2 Jan 2020

A HSC surface marker plays key role in ontogeny of hematopoiesis

A group of researchers at Osaka University revealed that ESAM (Endothelial cell-selective adhesion molecule), a surface marker for hematopoietic stem cells (HSCs) and vascular endothelial cells (ECs), played an important role in the ontogeny of hematopoiesis in mice, particularly in the development of adult-type erythropoiesis.

26 Dec 2019

Scientists develop 3D atlas of bone marrow to help study blood diseases

The bone marrow, which is the spongy and viscous tissue that fills the bone, is the site of blood cell formation or hematopoiesis. If the bone marrow doesn’t work properly, it can lead to many blood diseases, including leukemia, sickle cell anemia, and lymphoma, among others.

23 Dec 2019

Study unlocks the potential for new therapies to help correct bone disorder

Osteogensis imperfecta is a group of genetic disorders that mainly affect the bone. Patients with OI have bones that break easily, sometimes with no apparent cause.

23 Dec 2019

Artificial intelligence can detect AML with high reliability

Artificial intelligence can detect one of the most common forms of blood cancer - acute myeloid leukemia (AML) - with high reliability.

20 Dec 2019

Scientists explain how a common virus causes havoc on bone marrow, organ transplant patients

For the first time, scientists have discovered the molecular mechanism behind how a common virus can wreak havoc on bone marrow and organ transplant patients, according to a paper published in the journal Cell & Host Microbe.

19 Dec 2019

Routine cardiac stress test turns into lifesaving gift

Erika Hosey, a cardiovascular technician at University Hospitals Ahuja Medical Center, ended the year by giving a life-changing gift to a patient in need. While performing a routine cardiac stress test, she drummed up a conversation. She learned that her patient, Denise Butvin, had kidney disease and needed transplant surgery.

19 Dec 2019

Leukemia patients treated with common cancer drug have heightened risk of heart failure

Patients with acute lymphoblastic leukemia or acute myeloid leukemia who are treated with anthracyclines are at a heightened risk of heart failure- most often within one year of exposure to the chemotherapy treatment, according to a new study led by researchers at Penn Medicine.

17 Dec 2019

New combination therapy can lead to durable responses in patients with multiple myeloma

An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies.

17 Dec 2019

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

In a clinical trial led by Yale Cancer Center and Smilow Cancer Hospital, researchers aim to exploit DNA mutations in the treatment of two blood and bone marrow cancers, a different tacit than the more traditional approach of blunting or switching off genetic mutations linked to cancer.

10 Dec 2019

Transplant patient finds out his DNA has been replaced by that of his donor

A bone marrow transplant recipient later found out that the DNA in his blood and semen had been replaced by that of his donor.

10 Dec 2019

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed.

10 Dec 2019

Study reveals new mechanism that contributes to bone maintenance and repair

Led by researchers at Baylor College of Medicine, a study published in the journal Cell Stem Cell reveals a new mechanism that contributes to adult bone maintenance and repair and opens the possibility of developing therapeutic strategies for improving bone healing.

9 Dec 2019

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

New findings published Dec. 9 in Nature Biomedical Engineering from scientists at Fred Hutchinson Cancer Research Center show for the first time that a piece of small, thin metal mesh loaded with cancer-fighting immune cells shrinks tumors in preclinical models of ovarian cancer.

9 Dec 2019

Genetic features of AML in older patients can predict outcomes after stem cell transplant

For older patients with acute myeloid leukemia, the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute and other research centers will report today at the 61st American Society of Hematology (ASH) Annual Meeting.

8 Dec 2019

Pilot clinical trial tests new treatment for type 1 diabetes

Type 1 diabetes is a chronic condition in which the body's own immune system attacks and destroys beta cells in the pancreas. Once the beta cells are destroyed, the pancreas can no longer produce insulin. Currently, there is no cure for T1D and treatment focuses on managing blood sugar levels.

6 Dec 2019

Adding post-transplant chemotherapy to standard treatment improves remission of allogeneic transplant patients

Investigators in the Blood and Marrow Transplant Program at Rutgers Cancer Institute of New Jersey compared outcomes for patients having undergone allogeneic stem cell transplant when post-transplant cyclophosphamide (PCy, a type of chemotherapy) was added as part of standard treatment to prevent disease through an immune response (immunoprophylaxis) than if this standard treatment was given alone.

5 Dec 2019

A major step toward preventing GvHD in patients receiving bone marrow transplants

A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use.

4 Dec 2019

Bone Marrow News and Research

Further Reading

Researchers develop new way to fight late-stage sepsis

Aspirin’s benefits may extend beyond heart health to colorectal cancer treatment

Researchers move closer to identifying leukemic stem cells

A HSC surface marker plays key role in ontogeny of hematopoiesis

Scientists develop 3D atlas of bone marrow to help study blood diseases

Study unlocks the potential for new therapies to help correct bone disorder

Artificial intelligence can detect AML with high reliability

Scientists explain how a common virus causes havoc on bone marrow, organ transplant patients

Routine cardiac stress test turns into lifesaving gift

Leukemia patients treated with common cancer drug have heightened risk of heart failure

New combination therapy can lead to durable responses in patients with multiple myeloma

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

Transplant patient finds out his DNA has been replaced by that of his donor

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

Study reveals new mechanism that contributes to bone maintenance and repair

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

Genetic features of AML in older patients can predict outcomes after stem cell transplant

Pilot clinical trial tests new treatment for type 1 diabetes

Adding post-transplant chemotherapy to standard treatment improves remission of allogeneic transplant patients

A major step toward preventing GvHD in patients receiving bone marrow transplants

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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