Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

On Thursday, April 7, the Centers for Medicare and Medicaid (CMS) formalized its plan to cover the anti-amyloid drug Aduhelm only for patients enrolled in clinical trials.

8 Apr 2022

Axol Bioscience Raises £3.2 Million GBP (c. $4.2 million USD)

Axol Bioscience Ltd. today announced that it has raised £3.2 million GBP in the extension of its previous funding round, bringing the total raised to £7 million GBP.

From Axol Bioscience Ltd 7 Apr 2022

High-throughput screening assay could identify new prostate cancer drugs

A novel high-throughput screening assay is designed to identify inhibitors of the androgen receptor, which plays a critical role in the progression of prostate cancer.

6 Apr 2022

UCI researchers reveal the impact of native lipids on rhodopsin signaling and regeneration

In a new study at University of California, Irvine, researchers have revealed the impact of native lipids on rhodopsin signaling and regeneration, which may usher in a new paradigm for discovery of drugs that target G protein-coupled receptors (GPCRs).

6 Apr 2022

Researchers develop novel device to “cleanse” the blood of chemotherapeutic drugs

For patients with cancer, the tumor-killing power of chemotherapeutic drugs is a double-edged sword. While many cancer drugs kill tumor cells, they can also harm healthy cells as they travel throughout the bloodstream.

6 Apr 2022

Arrayjet introduces Mercury range of next-generation microarray printers

Arrayjet, a leading provider of inkjet liquid-handling solutions, today introduced Mercury, a new core range of five instruments for ultra-low-volume liquid dispensing.

From Arrayjet Ltd 4 Apr 2022

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Scientists discuss the pathogenic characteristics of SARS-CoV-2 and available therapeutic interventions for treating COVID-19.

3 Apr 2022

Clinical health outcomes of omicron ‘less severe’ than delta for pediatric patients

New research from the Case Western Reserve University (CWRU) School of Medicine suggests that the children younger than age 5 who are infected with the COVID-19 Omicron variant have less risk of severe health outcomes than those infected with the Delta variant.

2 Apr 2022

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

Furin inhibitors as potential therapeutics for treating COVID-19 and other diseases, wherein furin is integral for their pathogenicity and progression.

29 Mar 2022

New tissue-clearing method could speed the study of many disease-related biological processes

Scientists at Scripps Research have unveiled a new tissue-clearing method for rendering large biological samples transparent.

29 Mar 2022

Utilizing AI to Accelerate the Field of High Content Analysis

In this interview, we speak to Araceli Biosciences about their latest product the Araceli Endeavor, and how its revolutionizing the field of high content screening.

From Society for Laboratory Automation and Screening (SLAS) 29 Mar 2022

CDK6: a potential drug target for severe COVID-19

Researchers identify a methodology and workflow to repurpose drugs against the cyclin-dependent kinase 6 target gene of SARS-CoV-2.

27 Mar 2022

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Researchers discuss alternate therapeutic targets for treating COVID-19 and the effects of Gal-9 on SARS-CoV-2 infection and the immune response.

23 Mar 2022

Study reveals new opportunities for using small molecule drugs to target KRAS mutants

Research published today in Nature Chemical Biology reveals new opportunities for using small molecule drugs to target KRAS, the most commonly mutated protein in cancer.

23 Mar 2022

Powerful tool to monitor membrane proteins trafficking for drug discovery

Inside your body on the surface of cell membranes, a metaphorical communication and traffic network is underway as hormones - or chemical messengers - bind to cell membrane receptors to fine tune how the cell behaves.

22 Mar 2022

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Researchers evaluate antiviral effects of CD63 tetraspanin extracellular vesicles against SARS-CoV-2 and HIV-1.

22 Mar 2022

The obstacles to developing high-throughput 3D wound healing models

In this interview, News-Medical talks to Dr. Glauco Souza and Linda Boekestijn about their work in the wound healing space and how they devised a new high throughput 3D model for would healing.

From PromoCell 22 Mar 2022

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

The immune system deteriorates with age, making COVID-19 particularly deadly in older people - but to date, no clinically available medication addresses this key risk factor.

21 Mar 2022

Study unveils several natural marine products as potential agents against SARS-CoV-2

A recent study, published in the Journal of Natural Products of the American Chemical Society and American Society of Pharmacognosy, highlighted three natural marine products as potent inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – without any apparent toxic effects for human lung cells.

21 Mar 2022

Optical coherence tomography reveals the beating and development of human heart organoids

Researchers have been using organoids - 3D organ-like, tightly-packed cell cultures - as models to study organ development, disease and drug discovery with excellent success.

16 Mar 2022

Drug Discovery News and Research

Further Reading

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

Axol Bioscience Raises £3.2 Million GBP (c. $4.2 million USD)

High-throughput screening assay could identify new prostate cancer drugs

UCI researchers reveal the impact of native lipids on rhodopsin signaling and regeneration

Researchers develop novel device to “cleanse” the blood of chemotherapeutic drugs

Arrayjet introduces Mercury range of next-generation microarray printers

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Clinical health outcomes of omicron ‘less severe’ than delta for pediatric patients

Furin inhibitors as potential therapies to combat SARS-CoV-2 and other diseases

New tissue-clearing method could speed the study of many disease-related biological processes

Utilizing AI to Accelerate the Field of High Content Analysis

CDK6: a potential drug target for severe COVID-19

Researchers investigate Galectin-9 as a new treatment target for COVID-19

Study reveals new opportunities for using small molecule drugs to target KRAS mutants

Powerful tool to monitor membrane proteins trafficking for drug discovery

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

The obstacles to developing high-throughput 3D wound healing models

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

Study unveils several natural marine products as potential agents against SARS-CoV-2

Optical coherence tomography reveals the beating and development of human heart organoids

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