Mouse Model News and Research

RSS

Repurposed drug shows promise as potential new treatment for motor neuron disease

A drug typically used to treat enlarged prostates and high blood pressure has shown promise as a potential new therapy for motor neuron disease (MND), according to a new study.

11 Aug 2022

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Scientists review current literature associated with the role of the gut-brain axis in AD pathogenesis.

9 Aug 2022

Researchers unravel a novel molecular target of eicosapentaenoic acid

Eicosapentaenoic acid (EPA) is an essential nutrient belonging to the omega-3 group of polyunsaturated fatty acids (PUFAs). As the human body cannot synthesize PUFAs, dietary supplements containing EPA are required for normal physiological functions. Found abundantly in natural sources like fish, hemp oil, and linseed oil, EPA is known to exhibit anti-inflammatory, neuroprotective, and cardiovascular protective activities.

9 Aug 2022

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Researchers demonstrated that vaccine frameworks containing deoxyribonucleic acid (DNA) origami possessing SARS-CoV-2 receptor-binding domain induce strong protective immunity.

8 Aug 2022

Terminally exhausted T cells may remain competent for transcription, researchers say

During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived.

8 Aug 2022

Optically controlled local heat-pulse method manipulates temperature in cells

A team of researchers led by Osaka University finds that mutant variants of the calcium channel protein RyR1 are hypersensitive to heat, which creates a positive feedback loop of calcium release and leads to malignant hyperthermia

8 Aug 2022

Vascular dysfunction may be the cause of metabolic changes that can lead to diabetes, study suggests

A major risk factor for diabetes, insulin resistance occurs when the cells of the body do not respond to insulin and cannot make use of the glucose (sugar) in the blood stream.

5 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety of chronic human ailments, including obesity, type 2 diabetes, atherosclerosis, cancer, non-alcoholic fatty liver disease and inflammatory bowel disease.

4 Aug 2022

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

We are increasingly being exposed to endocrine-disrupting chemicals (EDCs) that interfere with the normal functioning of our hormones. Bisphenol A (BPA) and phthalates, which are widely used in consumer products including plastics, aluminum cans, pharmaceuticals, and cosmetics, are well-known EDCs.

4 Aug 2022

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Two years ago, University of Alabama at Birmingham researchers and colleagues reported that reductive stress - an imbalance in the normal oxidation/reduction, or redox, homeostasis - caused pathological changes associated with heart failure in a mouse model.

3 Aug 2022

Gene therapy approach delays disease onset in humanized mouse models of familial ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control.

2 Aug 2022

Study reveals how barrier cells that line the intestines send messages to patrolling T cells

Cells in the gut send secret messages to the immune system. Thanks to new research from La Jolla Institute for Immunology (LJI) scientists, we can finally get a look at what they're saying.

29 Jul 2022

SARS-CoV-2 spike subunit 2–targeted vaccine could more effectively combat all human coronaviruses

In a new study, researchers evidenced that the S2 subunit of SARS-CoV-2 spike (S) could be an integral component of a pan-coronavirus vaccine.

29 Jul 2022

New glioma drug may represent a paradigm for designing therapeutics exploiting specific DNA repair

A new class of glioma drugs exploits tumors that lack the DNA repair enzyme MGMT; the drugs lead to the generation of cytotoxic DNA and selectively kill tumor cells without the risk of resistance, researchers report.

29 Jul 2022

Bivalent mRNA vaccine induces powerful antibody response to SARS-CoV-2 Omicron subvariants

Researchers discuss the development and efficacy of a bivalent mRNA vaccine against emerging variants such as BA.2.12.1, BA.4, or BA.5.

25 Jul 2022

Research reveals molecular clues associated with traumatic brain injury

New research led by scientists at Arizona State University has revealed some of the first detailed molecular clues associated with one of the leading causes of death and disability, a condition known as traumatic brain injury (TBI).

23 Jul 2022

Two UTHSC research teams receive CORNET Awards for novel projects

Two research teams at the University of Tennessee Health Science Center (UTHSC) have been awarded the 2022 UTHSC Collaborative Research Network (CORNET)-Functional Genomics Award. Each team will receive $50,000 to support their novel projects.

22 Jul 2022

Study clarifies the role of intestinal white blood cells in colorectal cancer

Colorectal tumors are swarming with white blood cells, but whether these cells help or hinder the cancer is hotly debated.

22 Jul 2022

Improving the immune defenses against blood cancer

For patients with lymphoma, multiple myeloma, or certain types of leukemia, treatment with chimeric antigen receptor T cells (CAR T cells) is sometimes the last chance of overcoming the cancer.

22 Jul 2022

Mouse Model News and Research

Repurposed drug shows promise as potential new treatment for motor neuron disease

Alzheimer’s disease is associated with characteristic gut metabolomic signatures

Researchers unravel a novel molecular target of eicosapentaenoic acid

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Terminally exhausted T cells may remain competent for transcription, researchers say

Optically controlled local heat-pulse method manipulates temperature in cells

Vascular dysfunction may be the cause of metabolic changes that can lead to diabetes, study suggests

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Gene therapy approach delays disease onset in humanized mouse models of familial ALS

Study reveals how barrier cells that line the intestines send messages to patrolling T cells

SARS-CoV-2 spike subunit 2–targeted vaccine could more effectively combat all human coronaviruses

New glioma drug may represent a paradigm for designing therapeutics exploiting specific DNA repair

Bivalent mRNA vaccine induces powerful antibody response to SARS-CoV-2 Omicron subvariants

Research reveals molecular clues associated with traumatic brain injury

Two UTHSC research teams receive CORNET Awards for novel projects

Study clarifies the role of intestinal white blood cells in colorectal cancer

Improving the immune defenses against blood cancer

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News