Mouse Model News and Research

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Research may lead to safer ways to care for patients impacted by blood clots

A nanoparticle therapy developed by investigators at University Hospitals (UH) and Case Western Reserve University targets overactive neutrophils, a specific kind of white blood cell, to prevent almost all types of blood clots while causing no increased risk for bleeding.

30 Sep 2022

Study reveals the role of autophagy in competitive elimination of cancer cells

Elimination of transformed cells that can initiate cancer is necessary to maintain tissue integrity. In a new study, scientists from Tokyo University of Science show how this mechanism is regulated by the cellular process “autophagy.”

30 Sep 2022

Researchers discover how cancer cells can turn off the immune system to help tumors grow

When cancer arises in the body, it starts with tumor cells that rapidly grow and divide and eventually spread.

29 Sep 2022

Mouse model reveals link between GABA receptors and sleepiness in people with myotonic dystrophy

People with the inherited disorder myotonic dystrophy (DM) often experience excessive daytime sleepiness and fatigue, as well as altered responses to anesthetics that can put them at risk for complications when hospitalized.

29 Sep 2022

Changes in temperature may be behind the link between circadian disruption and cancer

Disruptions in circadian rhythm - the ways that our bodies change in response to the 24-hour light and dark cycle - have been linked to many different diseases, including cancer.

28 Sep 2022

New compound triggers the same anti-depressant action as rapidly acting psychedelic drugs

While illegal for recreational use, psychedelic drugs are showing great promise as treatments for severe depression and anxiety, as well as alcohol addiction and other conditions.

28 Sep 2022

New Zika vaccine technology found to be highly effective and safe in preclinical mouse models

Researchers from the University of California, Los Angeles have developed a Zika vaccine technology that is highly effective and safe in preclinical mouse models.

28 Sep 2022

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

Infertility is a global public health problem caused by genetic defects, lifestyle, nutrition, and factors affecting the local metabolism and microenvironment of the reproductive system.

26 Sep 2022

Does leptin play a role in Parkinson’s disease?

Scientists review in vitro and in vivo evidence associated with Parkinson's disease and leptin.

26 Sep 2022

LncDACH1 may be a potential therapeutic target for pulmonary fibrosis

This new article publication from Acta Pharmaceutica Sinica B, discusses how LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation.

26 Sep 2022

Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

Currently, spinal cord injury does not have any effective treatments; physical rehabilitation can help patients regain some mobility, but for severe cases the outcomes are extremely limited by the failure of spinal neurons to regenerate naturally after injury.

20 Sep 2022

Overload of stress granules enables the growth of obesity-related pancreatic cancer

Obesity is a known risk factor for at least 13 types of cancer, in part because it creates ever-present inflammatory state. For years, one researcher has wondered if there's more to the story than inflammation.

20 Sep 2022

Intact autophagic vacuoles found to be indispensable in mediating competitive elimination of cancer cells

19 Sep 2022

Researchers identify a promising bacterial target for vaccine development

Acinetobacter baumannii is a bacterial pathogen responsible for serious hospital-related infections that is becoming increasingly resistant against antibiotics.

19 Sep 2022

Study identifies a promising target for polycystic kidney disease treatment

Blocking the inhibition of PKD1 and PKD2 gene expression by deleting a binding site for microRNAs hindered the formation and growth of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD) models, UT Southwestern researchers reported.

16 Sep 2022

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

A new paper discusses the hope held out by recent results on a compound called irisin, a short protein secreted by skeletal muscle that produces some exercise-related effects on the brain.

15 Sep 2022

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Researchers at Oregon State University and Oregon Health & Science University have developed a promising, first-of-its-kind messenger RNA therapy for ovarian cancer as well as cachexia, a muscle-wasting condition associated with cancer and other chronic illnesses.

13 Sep 2022

Gut commensal bacteria promote the development of virus-induced cancer by suppressing the immune system

Gut bacteria have a profound impact on health by aiding digestion, providing nutrients and metabolites, and working with the immune system to fend off pathogens.

13 Sep 2022

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Researchers at Johns Hopkins Medicine report that an experimental drug first developed to treat kidney disease prolongs survival and improves muscle function in mice genetically engineered to develop a severe form of Duchenne muscular dystrophy (DMD).

13 Sep 2022

Age-related changes in microbiome composition affects brain macrophages

Scientists review the impact of age-related gut microbiome composition on age-associated diseases caused by dysfunctional macrophages within the brain.

13 Sep 2022

Mouse Model News and Research

Research may lead to safer ways to care for patients impacted by blood clots

Study reveals the role of autophagy in competitive elimination of cancer cells

Researchers discover how cancer cells can turn off the immune system to help tumors grow

Mouse model reveals link between GABA receptors and sleepiness in people with myotonic dystrophy

Changes in temperature may be behind the link between circadian disruption and cancer

New compound triggers the same anti-depressant action as rapidly acting psychedelic drugs

New Zika vaccine technology found to be highly effective and safe in preclinical mouse models

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

Does leptin play a role in Parkinson’s disease?

LncDACH1 may be a potential therapeutic target for pulmonary fibrosis

Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

Overload of stress granules enables the growth of obesity-related pancreatic cancer

Intact autophagic vacuoles found to be indispensable in mediating competitive elimination of cancer cells

Researchers identify a promising bacterial target for vaccine development

Study identifies a promising target for polycystic kidney disease treatment

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Gut commensal bacteria promote the development of virus-induced cancer by suppressing the immune system

Experimental drug prolongs survival, improves muscle function in mice severe Duchenne muscular dystrophy

Age-related changes in microbiome composition affects brain macrophages

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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