Mutation News and Research

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Discovery of protein that stops the growth of melanomas

One might call it a tale of two melanocytes. Given the same genetic mutation, why does one melanocyte shut down growth and become a relatively benign mole, while another rages out of control and develops into deadly melanoma"

8 Feb 2008

Bone problems and cystic fibrosis

A recent study by Dr Christina Haston, a researcher of the McGill University Health Centre research Institute, sheds some new light on the bone problems that generally accompany cystic fibrosis.

8 Feb 2008

New research allays some panic about suspected cancer-causing agents

A risk assessment tool has been developed through the Cancer Control Program at South Eastern Sydney & Illawarra Health (SESIH) by a University of New South Wales (UNSW) researcher, Professor Bernard Stewart.

7 Feb 2008

New approach to genetic diagnosis in autism

A practical, stepwise approach to diagnosing genetic causes of autism and related disorders is proposed in the January issue of Genetics in Medicine, official journal of the American College of Medical Genetics (ACMG), published by Lippincott Williams & Wilkins.

7 Feb 2008

New understanding of cancer initiation

Researchers at the University of Nebraska Medical Center (UNMC) in Omaha have assisted in a significant discovery - the understanding of a common mechanism of cancer initiation - that could result in better cancer assessment, prevention and detection.

7 Feb 2008

Chemical chaperone could open door to treatment of neurological disorder

An unexpected finding turned out to be a clue leading researchers at Washington University School of Medicine in St. Louis to propose a new treatment approach for Niemann-Pick disease, a rare, deadly neurodegenerative disorder.

7 Feb 2008

Experimental drug shows promise for cystic fibrosis

An experimental drug that has proven effective in treating muscular dystrophy also works for cystic fibrosis, according to researchers at the University of Alabama at Birmingham (UAB).

5 Feb 2008

Study of successful drug targets could hasten development of new medications

Guidance from an innovative computational approach could speed up the process and cut down the cost of new drug development, researchers from the University of Chicago Medical Center and Columbia University suggest in a study to be published in the February 2008 issue of Genome Research, available early online.

5 Feb 2008

Chemists track how amantadine drug changes, blocks flu virus

An anti-virus drug attacks influenza A by changing the motion and structure of a proton channel necessary for the virus to infect healthy cells, according to a recently published research paper by two Iowa State University chemists.

5 Feb 2008

Genetic mutations in the Toll-like receptor 4 gene increase risk of preterm birth

Genetic mutations in the Toll-like receptor 4 (TLR4) gene appear to have significant association with inflammatory injury to the placenta and developing baby, researchers from the University of Pittsburgh's department of obstetrics, gynecology and reproductive sciences report at the 28th annual meeting of the Society for Maternal-Fetal Medicine.

5 Feb 2008

Researchers identify cells that cause nervous system disease

Two teams of University of Michigan researchers have tracked down the cells responsible for neurofibromatosis type1, a disfiguring, incurable condition and one of the most common hereditary disorders.

4 Feb 2008

Researchers uncover key interaction in cholesterol regulation

Researchers at UT Southwestern Medical Center have determined the specific way in which a destructive protein binds to and interferes with a molecule that removes low-density lipoproteins (LDL), the so-called "bad" cholesterol, from the blood.

4 Feb 2008

Targeting astrocytes slows progression of Lou Gehrig's disease

In what the researchers say could be promising news in the quest to find a therapy to slow the progression of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, scientists at the University of California, San Diego (UCSD) School of Medicine have shown that targeting neuronal support cells called astrocytes sharply slows disease progression in mice.

4 Feb 2008

New research shows that people with blue eyes have a single, common ancestor

A team at the University of Copenhagen have tracked down a genetic mutation which took place 6-10,000 years ago and is the cause of the eye colour of all blue-eyed humans alive on the planet today.

4 Feb 2008

Variation in the BCL11A gene linked to moderated symptoms of beta-thalassemia

Beta-thalassemia is a serious, potentially life-threatening disease that affects red blood cells, cells that carry oxygen via hemoglobin throughout the body.

4 Feb 2008

A loss in DNS repair function causes acute myeloid leukemia relapse

A University of Kentucky research team reports that loss of an important DNA repair function, called DNA mismatch repair (MMR), is responsible for refractory/relapsed Acute Myeloid Leukemia (AML).

4 Feb 2008

New target for flu prevention

Emerging subtypes of influenza A virus hold the potential to initiate a world-wide epidemic in the next few years, according to World Health Organization officials.

4 Feb 2008

New research allays some panic about suspected cancer-causing agents

New research has allayed some panic about suspected cancer-causing agents, such as deodorants, coffee and artificial sweeteners. A risk assessment tool has been developed through the Cancer Control Program at South Eastern Sydney & Illawarra Health (SESIH) by a University of New South Wales (UNSW) researcher, Professor Bernard Stewart.

4 Feb 2008

Viruses for a healthy pregnancy

Sequences of DNA in the human genome that originated from ancient viral infections have some surprising effects on our bodies and are even essential for a healthy pregnancy, according to an article in the February issue of Microbiology Today.

31 Jan 2008

Virtual human in HIV drug simulation

The combined supercomputing power of the UK and US 'national grids' has enabled UCL (University College London) scientists to simulate the efficacy of an HIV drug in blocking a key protein used by the lethal virus.

31 Jan 2008