Cartilage News and Research

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Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.

Patient enrollment in Phase II study of BioCart Autologous Cartilage System nearing halfway point

ProChon Biotech, Ltd., an innovator of tissue regenerative technologies that are being developed to relieve pain and restore the mobility and quality-of-life for sufferers of articular cartilage injuries, today announced that patient enrollment in the Company’s Phase II study of the BioCart™ Autologous Cartilage System is nearing the halfway point and is expected to be completed within the next three months.

5 Mar 2010

Translational Regenerative Medicine Forum in Winston-Salem

A spray-on skin product and an injectable cell therapy for heart attack patients are among 17 regenerative medicine technologies that will be showcased during the Translational Regenerative Medicine Forum, set for April 6-8 in Winston-Salem.

25 Feb 2010

End-stage ankle arthritis: New treatment options for baby boomers

There's good news for active older adults who are plagued with arthritic ankles. Surgeons presenting today at the American College of Foot and Ankle Surgeons' Annual Scientific Conference in Las Vegas are re-thinking treatment approaches for end-stage ankle arthritis.

25 Feb 2010

SSRIs exhibit anti-inflammatory effects and may provide drug development opportunities for RA

A new study found that fluoxetine (Prozac-) and citalopram (Celexa-) treatment significantly inhibited disease progression of collagen-induced arthritis (CIA) in mice. Research led by Sandra Sacre, Ph.D. from the Brighton and Sussex Medical School (BSMS) in the UK studied the anti-arthritic potential of these drugs, known as selective serotonin reuptake inhibitors (SSRIs), most commonly used to treat depression.

25 Feb 2010

AOSSM and RTI Biologics award $250,000 grant for ligament and tendon repair and regeneration research

Dr. Robert C. Bray of the University of Calgary was recently selected as the winner of the American Orthopaedic Society for Sports Medicine's (AOSSM) $250,000 Ligament and Tendon Repair and Regeneration Grant for his project, "Biological Augmentation of Ligament and Tendon Healing: Role of Neuropeptides."

25 Feb 2010

Smith & Nephew launches DYONICS RF System to remove soft tissue during arthroscopic surgery

Smith & Nephew's Endoscopy Division today announced the launch of the DYONICS™ RF System, which incorporates a compact generator with a family of probes for aggressively removing defects and smoothing soft tissue during arthroscopic surgery.

24 Feb 2010

Study shows CEL-2000 vaccine blocks RA progression in mice

CEL-SCI Corporation and their scientific collaborators announced today that the Company's CEL-2000 vaccine demonstrated that it is able to block the progression of rheumatoid arthritis (RA) in a mouse model.

23 Feb 2010

Single test is not enough for making accurate diagnosis of disc herniation

While lower back pain ranks as a common cause of disability in the United States, determining what causes a person's back pain is often challenging. A new Cochrane review on diagnosing back pain finds that no single diagnostic test is good at discriminating between patients who have a herniated disc and patients who do not, according to lead author Danielle van der Windt.

18 Feb 2010

BioMimetic Therapeutics annouces completion of Augment Bone Graft PMA submission

BioMimetic Therapeutics, Inc. today announced it has submitted the third and final module of its Premarket Approval (PMA) application for marketing of Augment™ Bone Graft in the U.S. This final module, containing a comprehensive review of the clinical data related to Augment, completes the PMA application to the FDA. The Company previously announced the filing of both the pre-clinical pharmacology/toxicology and quality/manufacturing modules with the FDA in June of 2009.

18 Feb 2010

New research report on orthopedic biomaterials market in the U.S.

According to a new global report series by iData Research (www.idataresearch.net), the leading authority in medical device, dental and pharmaceutical market research, the U.S. market for orthopedic biomaterials grew by 11.5% in 2009 and is estimated to reach almost $6.3 billion by 2016.

17 Feb 2010

AstraZeneca, Rigel Pharmaceuticals announce exclusive worldwide license agreement for R788

AstraZeneca and Rigel Pharmaceuticals today announced an exclusive worldwide license agreement for the global development and commercialization of fostamatinib disodium (R788), Rigel's late-stage investigational product for rheumatoid arthritis (RA) and additional indications.

16 Feb 2010

Fast method for producing bone and cartilage tissue using body's own cells

Injuries to joints and cartilage can have serious consequences, including osteoarthritis. Cartilage degeneration in joints is a widespread disease in Germany and worldwide. Prof. Dr. Prasad Shastri is an expert in tissue engineering (TE), tissue construction and tissue cultivation using the body's own cells. He is Professor of Biofunctional Macromolecular Chemistry at the Centre for Biological Signalling Studies (BIOSS), a Cluster of Excellence at the University of Freiburg, where he has been researching for the last year.

15 Feb 2010

New project to unravel secret lives of cancer cells may help produce new cancer therapies

A team of scientists from Princeton University and The Cancer Institute of New Jersey has embarked on a major new project to unravel the secret lives of cancer cells that go dormant and self-cannibalize to survive periods of stress. The work may help produce new cancer therapies to stem changes that render cancer cells dangerous and resistant to treatment.

12 Feb 2010

Better and standardized animal models needed for musculoskeletal regenerative medicine

Clinical testing and development of novel therapies based on advances in tissue engineering and regenerative medicine that will one day enable the repair and replacement of diseased or damaged human muscle, bone, tendons, and ligaments depends on the availability of good animal models.

12 Feb 2010

Winter Sports: Tips on proper training, and prevention of injuries and concussions

According to the Centers for Disease Control and Prevention, 46 percent of children admitted to trauma centers for winter sports injuries have been diagnosed with a head injury – the majority of them from snowboarding, sledding, skiing, ice skating or ice hockey. Pediatric sports medicine is a growing field and is a direct response to how active today’s children are in competitive and recreational sports.

11 Feb 2010

Study sheds new light on cancer metastasis

Some cells are natural rule-breakers. Neural crest cells for example, not only migrate throughout the body during development (most cells are more selective in their wandering), they are also more developmentally flexible than their predecessors (a no-no for nearly all cell types).

4 Feb 2010

Blood cytokine levels may help in predicting arthritic rheumatism

Levels of inflammatory proteins, so-called cytokines, are elevated in the blood even before the onset of arthritic rheumatism. This means that such blood samples could be used to predict the development of the disease and thereby make it possible to prevent the pathological process, according to an article by Umeå researcher Solbritt Rantapää-Dahlqvist and her associates in the journal Arthritis and Rheumatism.

4 Feb 2010

Nanotope’s bioactive nanofiber system promotes cartilage regeneration

Arrowhead Research Corporation today announced publication in Proceedings of the National Academy of Sciences (PNAS) of a study using Nanotope’s lead compound for cartilage regeneration. The study’s authors, which include Nanotope co-founder Dr. Samuel Stupp, showed that Nanotope’s bioactive nanofiber system promotes the growth of new cartilage in a rabbit model. The treatment is engineered to repair cartilage defects by working with an animal’s own bone marrow stem cells to stimulate the production of new natural cartilage.

3 Feb 2010

Nanotope publishes preclinical data demonstrating cartilage regeneration

Arrowhead Research Corporation has announced publication in Proceedings of the National Academy of Sciences (PNAS) of a study using Nanotope's lead compound for cartilage regeneration.

3 Feb 2010

Gentag signs license agreement to develop and commercialize post surgery wireless skin patch

Gentag, Inc. and The CORE Institute® are pleased to announce the signing of a license agreement to develop and commercialize a disposable wireless skin patch to allow patients to self monitor themselves in the comfort of their homes after orthopedic surgery in hospitals through the use of cell phones

2 Feb 2010

Cartilage News and Research

Further Reading

Patient enrollment in Phase II study of BioCart Autologous Cartilage System nearing halfway point

Translational Regenerative Medicine Forum in Winston-Salem

End-stage ankle arthritis: New treatment options for baby boomers

SSRIs exhibit anti-inflammatory effects and may provide drug development opportunities for RA

AOSSM and RTI Biologics award $250,000 grant for ligament and tendon repair and regeneration research

Smith & Nephew launches DYONICS RF System to remove soft tissue during arthroscopic surgery

Study shows CEL-2000 vaccine blocks RA progression in mice

Single test is not enough for making accurate diagnosis of disc herniation

BioMimetic Therapeutics annouces completion of Augment Bone Graft PMA submission

New research report on orthopedic biomaterials market in the U.S.

AstraZeneca, Rigel Pharmaceuticals announce exclusive worldwide license agreement for R788

Fast method for producing bone and cartilage tissue using body's own cells

New project to unravel secret lives of cancer cells may help produce new cancer therapies

Better and standardized animal models needed for musculoskeletal regenerative medicine

Winter Sports: Tips on proper training, and prevention of injuries and concussions

Study sheds new light on cancer metastasis

Blood cytokine levels may help in predicting arthritic rheumatism

Nanotope’s bioactive nanofiber system promotes cartilage regeneration

Nanotope publishes preclinical data demonstrating cartilage regeneration

Gentag signs license agreement to develop and commercialize post surgery wireless skin patch

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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