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Researchers discover how traffic jam in intracellular sorting can cause tumor development

For tissues to cooperate and perform normal functions, cells need to know which way is up. When cells lose track of their orientation, they can start to grow out of control, and develop into cancer.

6 Nov 2017

An alternative approach to augmenting the effect of antibiotics in chronic CF lung infections

There are about 77,000 people known to have cystic fibrosis. That's from the various cystic fibrosis registries available globally. The World Health Organization suggests that this number may be low, because there's no reporting on cystic fibrosis from the developing world. The accepted number, at the moment, is about 80,000. That's the one that is used for most of the work that's being done on cystic fibrosis.

From Neem Biotech 3 Nov 2017

Study demonstrates beneficial effects of calorie-restricted diet in mice

Caloric restriction diets have been associated with various health benefits, but their effects on the skin have not been previously demonstrated. Research conducted at the University of São Paulo (USP) in Brazil shows that controlling calories helps mice live longer, although it reduces the reserves of fat in adipose tissue needed to keep the body warm.

30 Oct 2017

Study reveals why Alzheimer's drugs fail in clinical trials

A tremendous amount of Amyloid-β peptide (Aβ) (a peptide of ～40 amino acids) accumulates in the brain of Alzheimer's disease patients. γ-Secretase inhibitors were designed to inhibit the enzymatic activity that produces Aβ. By reducing Aβ production, γ-secretase inhibitors were considered able to treat Alzheimer's disease (Aβ hypothesis).

25 Oct 2017

Scientists develop unique CRISPR-based method for more precise, systematic gene tagging

The genome editing tool known as CRISPR/Cas9 has opened many doors for biomedical research by allowing scientists to precisely edit DNA sequences and alter function. The technology offers hope for correcting genetic defects and preventing disease.

24 Oct 2017

New model predicts how E. coli bacteria respond to temperature changes, genetic mutations

Researchers at the University of California San Diego have developed a genome-scale model that can accurately predict how E. coli bacteria respond to temperature changes and genetic mutations.

13 Oct 2017

Awards for contributions to analytical chemistry and applied spectroscopy announced by Pittcon

The Pittcon Program Committee is pleased to announce this year’s recipients of 13 prestigious awards honoring scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each award will be presented in a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory science, which will be held February 26-March 1, Orange County Convention Center, Orlando, Florida.

From Pittcon 10 Oct 2017

Study reveals link between dietary potassium and vascular calcification

A new study conducted at the University of Alabama at Birmingham suggested that potassium rich food like avocados and bananas might aid in protection against hardening of the arteries, also mentioned as pathogenic vascular calcification.

6 Oct 2017

Foods rich in potassium may help protect against vascular calcification

Bananas and avocados -- foods that are rich in potassium -- may help protect against pathogenic vascular calcification, also known as hardening of the arteries.

5 Oct 2017

Light-activated nanoparticles can provide crucial boost in effectiveness for antibiotics

Light-activated nanoparticles, also known as quantum dots, can provide a crucial boost in effectiveness for antibiotic treatments used to combat drug-resistant superbugs such as E. coli and Salmonella, new University of Colorado Boulder research shows.

4 Oct 2017

Researchers test new strategy to increase effectiveness of topical anesthesia used in dentistry

Researchers from Brazil and Texas have started testing on humans a new strategy to increase the effectiveness of topical anesthesia used in dentistry, used by dentists to reduce patient discomfort during the application of injected anesthesia - required for more invasive procedures such as fillings, tooth extraction or surgery.

4 Oct 2017

New way of tagging exosomes could have long term benefits in treatment of life-threatening conditions

The development of a new technique for labelling the body’s own transporters – exosomes - could have long term benefits in the treatment of life-threatening medical conditions, including cancer.

28 Sep 2017

Research reveals novel mechanism of ribosome dimerization using cryo-electron microscopy

Antibiotics are the most common medication used to treat microbial infections. Many antibiotics target intracellular bacterial ribosomes - cellular factories that synthesize proteins - which are essential for bacterial survival and proliferation.

28 Sep 2017

Bacteria release membrane-derived vesicles that may have different functions during infection

Bacteria release membrane-derived vesicles (MVs), which are small particles that can transport virulence factors to neighboring bacteria or to the cells of a mammalian host. This special MV-based system for delivering toxic proteins and nucleic acids in a protected manner to the target cells may have different specific functions depending on whether the bacterium acts as an extracellular or intracellular pathogen.

18 Sep 2017

Research highlights problems with titanium based nanoparticles in joint implants

A team of researchers from Mayo Clinic have found that that Titanium Dioxide (TiO2) nanoparticles that are present in bone implants may be causing harm by impairing bone formation and interfering with resorption at the site of repair. This can lead to loosening of the implants and pain.

15 Sep 2017

Researchers develop fluorescent sensors for detecting, tracking GTP levels in living cells

For several decades, scientists have recognized the key role that a molecule known as GTP, one of the building blocks of RNA, plays in the development of cancer and other diseases.

13 Sep 2017

Researchers identify protein that offers likely target for treating high-risk pediatric cancers

Oncology researchers studying high-risk children's cancers have identified a protein that offers a likely target for immunotherapy--harnessing the immune system in medical treatments. In cell cultures and animal models, a potent drug attached to an antibody selectively zeroes in on cancer cells without harming healthy cells.

11 Sep 2017

Study sheds light on virulence strategy of intracellular bacteria that cause legionellosis

Intracellular pathogens adopt various strategies to circumvent the defences of the host cell and to proliferate intracellularly. One specific strategy is to target host organelles like the mitochondria. Mitochondria are well-defined cytoplasmic organelles, which take part in a variety of cellular metabolic functions.

7 Sep 2017

Discovery of sugar 'warehouse' provides new metabolic target to regulate immune activity

A surprising discovery that immune cells possess an internal warehouse of glycogen used to activate immune responses could help to increase immune activity in vaccines or suppress immune reactions in autoimmune disease or hyper-inflammatory conditions.

6 Sep 2017

Research provides novel insights into bacterial toxins

A toxin produced by a bacterium that causes urinary tract infections is related to, yet different in key ways from, the toxin that causes whooping cough, according to new research.

5 Sep 2017