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Adagrasib shows promise for the treatment of patients with KRAS G12C-mutated non-small cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center found the KRAS G12C inhibitor adagrasib showed promising activity suppressing cancer growth not only within the lungs but also in brain metastases for patients with KRAS G12C-mutated non-small cell lung cancer.

16 Jun 2023

Mutations that lead to intracranial aneurysms discovered

Researchers at the RIKEN Center for Brain Science (CBS) in Japan have discovered a set of related mutations that lead to intracranial aneurysms - weakened blood vessels in the brain that can burst at any time.

14 Jun 2023

Scientists develop two novel oral polio vaccines to bolster WHO's push to eradicate polio

Despite some of the most successful international vaccination campaigns in history, the poliovirus continues to circulate around the world, posing a threat of neurological damage and even paralysis to anyone who is not vaccinated.

14 Jun 2023

Metformin shows promising antiviral activity against SARS-CoV-2

Metformin, a widely available oral medication, reduces SARS-CoV-2 viral load by 3.6-fold in outpatient trial, offering a potential treatment option. Ivermectin and fluvoxamine show no significant virologic effect.

12 Jun 2023

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

UBQLN2 dysfunction in ALS leads to elevated PEG10 levels, suggesting a role for retrotransposon activity in the disease. PEG10's nuclear localization alters gene expression involved in axon remodeling, implicating it as a contributing mechanism in ALS.

7 Jun 2023

Ancient, virus-like protein may contribute to ALS

More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to speak, move, eat and breathe.

7 Jun 2023

Study identifies new altered neural circuits in Huntington’s disease

Huntington's disease is a genetically-based neurodegenerative disorder that causes motor, cognitive and psychiatric disorders in the affected individuals.

7 Jun 2023

Promising targeted therapy offers new hope to certain patients with advanced pancreatic cancer

A promising new targeted cancer therapy will soon be available to certain patients with advanced pancreatic cancer – from the comfort of their home.

7 Jun 2023

Differences in tumor mutation burden are a major reason for divergence: Study

The expected course of a patient's cancer prognosis has traditionally been judged by its type, stage and microscopic aggressiveness, but patients with the same presentation can still have widely divergent outcomes. Researchers from Vanderbilt-Ingram Cancer Center have discovered that differences in tumor mutation burden are a major reason for this divergence.

7 Jun 2023

Spinal neural circuit dysfunction mediates movement symptoms in dystonia

Many neurological conditions that involve involuntary muscle contractions have long been considered as diseases of the brain.

6 Jun 2023

Experts investigate the correlation between BORIS mutations and protein expression

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression."

6 Jun 2023

The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

Researchers investigate Nsp1 from SARS-CoV-2, MERS-CoV, and Bat-Hp-CoV using biophysical, structural, and biochemical assays.

5 Jun 2023

Simple blood test for the diagnosis of Glut1 deficiency syndrome

Glut1 deficiency syndrome is a rare and disabling neurological disease still relatively unknown to the medical community.

5 Jun 2023

New insights into the importance of microglia in controlling anxiety-related behaviors

The pandemic and its aftermath have raised anxiety to new levels. But the roots of anxiety-related conditions, including obsessive-compulsive spectrum disorder (OCSD), are still unclear.

5 Jun 2023

New research reveals the genetic diversity and evolutionary history of primates

The rich genetic diversity and evolutionary history of primates – the group that includes monkeys, apes, lemurs and humans ourselves - has been revealed in full for the first time in a new research paper published today.

5 Jun 2023

NCI launches new initiative to test new drug combinations that target specific tumor alterations

The National Cancer Institute (NCI) has launched a large precision medicine cancer initiative to test the effectiveness of treating adults and children with new drug combinations that target specific tumor alterations.

1 Jun 2023

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

Researchers from Children's Hospital of Philadelphia (CHOP) recently discovered that extremely thorough "deep sequencing" of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods.

1 Jun 2023

UNIGE researchers identify how the influenza A virus manages to penetrate host cells

Influenza epidemics, caused by influenza A or B viruses, result in acute respiratory infection. They kill half a million people worldwide every year.

31 May 2023

Aggressive lung pathogen may not be prone to person-to-person transmission

A little-known bacterium - a distant cousin of the microbes that cause tuberculosis and leprosy - is emerging as a public health threat capable of causing severe lung infections among vulnerable populations, those with compromised immunity or reduced lung function.

30 May 2023

Mutated gene protects the kidney from hypertension-induced damage

A mutation that causes severe hypertension also protects the kidneys from being damaged, reports a team led by Enno Klußmann of the Max Delbrück Center and the DZHK in "Kidney International".

30 May 2023

Mutation News and Research

Adagrasib shows promise for the treatment of patients with KRAS G12C-mutated non-small cell lung cancer

Mutations that lead to intracranial aneurysms discovered

Scientists develop two novel oral polio vaccines to bolster WHO's push to eradicate polio

Metformin shows promising antiviral activity against SARS-CoV-2

Scientists uncover key molecular culprit in ALS: PEG10 gene implicated in pathogenesis

Ancient, virus-like protein may contribute to ALS

Study identifies new altered neural circuits in Huntington’s disease

Promising targeted therapy offers new hope to certain patients with advanced pancreatic cancer

Differences in tumor mutation burden are a major reason for divergence: Study

Spinal neural circuit dysfunction mediates movement symptoms in dystonia

Experts investigate the correlation between BORIS mutations and protein expression

The universal role of Nsp1: Common mechanisms of translational shutdown by coronaviruses

Simple blood test for the diagnosis of Glut1 deficiency syndrome

New insights into the importance of microglia in controlling anxiety-related behaviors

New research reveals the genetic diversity and evolutionary history of primates

NCI launches new initiative to test new drug combinations that target specific tumor alterations

"Deep sequencing" of the genome informs diagnoses and treatment of vascular anomalies

UNIGE researchers identify how the influenza A virus manages to penetrate host cells

Aggressive lung pathogen may not be prone to person-to-person transmission

Mutated gene protects the kidney from hypertension-induced damage

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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