Nephropathy News and Research

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Nephropathy is a broad medical term used to denote disease or damage of the kidney, which can eventually result in kidney failure. The primary and most obvious functions of the kidney are to excrete any waste products and to regulate the water and acid-base balance of the body – therefore loss of kidney function is a potentially fatal condition.

FDA EMDAC votes to recommend approval of Merck's VYTORIN for pre-dialysis CKD

Merck, known as MSD outside the United States and Canada, announced today that the Endocrinologic and Metabolic Drugs Advisory Committee of the U.S. Food and Drug Administration (FDA) unanimously voted to recommend approval of Merck's VYTORIN (ezetimibe/simvastatin) for use in patients with pre-dialysis chronic kidney disease.

3 Nov 2011

Hospitalized diabetic patients with acute kidney injury more likely to develop CKD

Findings from a recent University of Cincinnati (UC) and Cincinnati Department of Veterans Affairs (VA) Medical Center study show that multiple episodes of acute kidney injury during hospital stays for patients with diabetes are associated with a risk for developing chronic kidney disease.

2 Nov 2011

NIH-funded project to discover biomarkers for type 2 diabetes

Arizona State University will lead a four-year, $5 million expanded initiative sponsored by the National Institutes of Health to discover proteins, or biomarkers, to help predict cardiovascular disease and to assess potential new treatments in people with type 2 diabetes.

2 Nov 2011

New computer-based tool enables early diagnosis of cancer

A computer-based tool could help GPs to speed up the diagnosis and treatment of patients suffering from two of the most common forms of cancer, potentially saving thousands of lives every year.

31 Oct 2011

Twelve students participate in Hartford Doctoral Fellows Program in Geriatric Social Work

Twelve outstanding students have been chosen as the newest participants in the Hartford Doctoral Fellows Program in Geriatric Social Work. The program is funded by the John A. Hartford Foundation, administered by The Gerontological Society of America, and directed by James Lubben, DSW, MPH.

29 Oct 2011

VUMC doctors to begin statin drug screening for rare genetic variation

Vanderbilt University Medical Center doctors announced today they will begin screening patients who take commonly prescribed statin drugs for a rare genetic variation that can increase risks for side effects from these drugs such as muscle aches, kidney damage and even death.

29 Oct 2011

Patients with ANCA-associated vasculitis harbor Flt1 protein that blocks blood vessel repair

In some kidney diseases, patients have high blood levels of a protein that blocks blood vessel repair, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology.

28 Oct 2011

RA drug reduces kidney cyst growth in ADPKD mouse model

Scientists at UC Santa Barbara have discovered that patients with an inherited kidney disease may be helped by a drug that is currently available for other uses.

28 Oct 2011

Sulodexide drug fails to benefit diabetes patients with kidney disease

What was hoped to be a promising new drug to protect the kidneys has failed to benefit diabetes patients with kidney disease, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology.

28 Oct 2011

Diabetic patients with mild kidney disease may benefit from vitamin B6 derivative

A vitamin B6 derivative may help slow or prevent the progression of mild kidney disease in patients with diabetes, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology.

28 Oct 2011

Medtronic initiates Symplicity System clinical study in treatment-resistant hypertension

Medtronic Inc. announced today the start of SYMPLICITY HTN-3, the company's U.S. clinical trial of the Symplicity Renal Denervation System for treatment-resistant hypertension.

From Medtronic 27 Oct 2011

Study provides details on genetics behind many metabolic diseases

In what is so far the largest investigation of its kind, researchers uncovered a wide range of new insights about common diseases and how they are affected by differences between two persons' genes. The results from this study could lead to highly targeted, individualized therapies.

27 Oct 2011

FDA's ODAC to review Affymax peginesatide NDA for treatment of CKD-associated anemia

Affymax, Inc. today announced that the U.S. Food and Drug Administration's (FDA) Oncologic Drugs Advisory Committee (ODAC) will review the New Drug Application (NDA) for peginesatide proposed for the treatment of anemia associated with chronic kidney disease (CKD) in adult patients on dialysis on December 7, 2011 during the afternoon session.

24 Oct 2011

Clues into how gene defects may cause ARPKD in babies

Babies born with autosomal recessive polycystic kidney disease (ARPKD) often develop kidney failure because they have very large kidneys filled with tiny cysts. Even with excellent medical care, about 30% die shortly after birth. New research now provides clues into how gene defects may cause this condition, which occurs in 1 out of 20,000 newborns.

22 Oct 2011

Americans on a sodium high: CDC report

A new study by federal government researchers shows that most Americans consume too much sodium, and new strategies and stronger efforts are needed to reduce the amount of dietary salt. Experts add that high levels of sodium consumption are associated with increased risk of high blood pressure, which can lead to heart disease and stroke.

20 Oct 2011

Winter health and safety tips

Winter is a special time for celebration. It should also be a time for added caution if you or someone in your family is an older adult. It is the season for falls, slips on icy streets, and other dangers that can be especially harmful for older adults. "Something as simple as a fall can be devastating for older men and women," says Dr. Evelyn Granieri, director of the Division of Geriatrics at NewYork-Presbyterian Hospital/The Allen Hospital. "Before the cold weather arrives, it is important to prepare."

20 Oct 2011

Data from Concert Pharmaceuticals' CTP-499 study to be presented at ASN Kidney Week 2011

Concert Pharmaceuticals, Inc. today announced that three abstracts relating to CTP-499, its clinical candidate for the potential treatment of diabetic nephropathy, have been accepted for poster presentations at the American Society of Nephrology's (ASN) Kidney Week 2011.

19 Oct 2011

African-Americans donate exclusively to family members for living kidney transplants

Family matters, especially when it comes to African-Americans and living kidney donation. In a study conducted at Wake Forest Baptist Medical Center, researchers found that African-Americans donate almost exclusively to family members for living kidney transplants, as compared to Caucasians.

19 Oct 2011

Viewpoints: CLASS decision ends fear of government bailout; the strengths and failings of U.S. health care

The problem, as numerous experts warned at the time, was whether the program could be run, as the law required, in a way that made it financially solvent for at least 75 years. The difficulty with the CLASS Act was ensuring that premiums could be set low enough to attract widespread participation but high enough to pay tbenefits. The risk was that the program would attract the sickest participants, who thought they might need its protections, and thereby drive premium prices ever higher in a spiral of dysfunctionhe promised.

19 Oct 2011

Nephron Dx to develop more accurate diagnostic kit for early detection of diabetic CKD

A new spin-off company from the National University of Singapore (NUS), called Nephron Dx, has recently been set up to develop a more accurate diagnostic kit for the earlier detection of diabetic chronic kidney disease. Nephron Dx aims to enter the multi-billion dollar kidney disease diagnostic market by 2013.

18 Oct 2011

Nephropathy News and Research

Further Reading

FDA EMDAC votes to recommend approval of Merck's VYTORIN for pre-dialysis CKD

Hospitalized diabetic patients with acute kidney injury more likely to develop CKD

NIH-funded project to discover biomarkers for type 2 diabetes

New computer-based tool enables early diagnosis of cancer

Twelve students participate in Hartford Doctoral Fellows Program in Geriatric Social Work

VUMC doctors to begin statin drug screening for rare genetic variation

Patients with ANCA-associated vasculitis harbor Flt1 protein that blocks blood vessel repair

RA drug reduces kidney cyst growth in ADPKD mouse model

Sulodexide drug fails to benefit diabetes patients with kidney disease

Diabetic patients with mild kidney disease may benefit from vitamin B6 derivative

Medtronic initiates Symplicity System clinical study in treatment-resistant hypertension

Study provides details on genetics behind many metabolic diseases

FDA's ODAC to review Affymax peginesatide NDA for treatment of CKD-associated anemia

Clues into how gene defects may cause ARPKD in babies

Americans on a sodium high: CDC report

Winter health and safety tips

Data from Concert Pharmaceuticals' CTP-499 study to be presented at ASN Kidney Week 2011

African-Americans donate exclusively to family members for living kidney transplants

Viewpoints: CLASS decision ends fear of government bailout; the strengths and failings of U.S. health care

Nephron Dx to develop more accurate diagnostic kit for early detection of diabetic CKD

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