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Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

Tafenoquine, a prodrug that could fulfill the criteria for a mass eradication campaign.

23 Apr 2024

New QR4 algorithm outperforms previous models in predicting cardiovascular disease risk

A new cardiovascular risk prediction algorithm.

23 Apr 2024

Does diabetes increase the risk of long COVID?

A recent study in eClinicalMedicine assesses whether individuals with diabetes are more susceptible to developing long COVID, analyzing a UK cohort to explore the prolonged impact of SARS-CoV-2 infection in this population.

22 Apr 2024

Greenspace exposure boosts gut and skin microbiota health, study finds

A systematic review in "Environmental International" found greenspace exposure enhances diversity and composition of gut and skin microbiota, but effects on oral, nasal, and ocular microbiota are unclear.

17 Apr 2024

Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances.

13 Apr 2024

NCCN 2024 Annual Conference focuses on practical applications for improving cancer care

The National Comprehensive Cancer Network (NCCN) - an alliance of leading cancer centers - hosted more than 1,700 oncology professionals during the NCCN 2024 Annual Conference on April 5-7.

13 Apr 2024

As bans spread, fluoride in drinking water divides communities across the US

Regina Barrett, a 69-year-old retiree who lives in this small North Carolina city southeast of Charlotte, has not been happy with her tap water for a while.

12 Apr 2024

Cannabis compound d-limonene reduces anxiety-inducing effects of THC

A Johns Hopkins Medicine-led research team has added to evidence that a chemical found naturally in cannabis (also known as marijuana) can - in the right amounts - lessen the anxiety-inducing effects of tetrahydrocannabinol (THC), the primary psychoactive sister chemical found in cannabis.

12 Apr 2024

Treating gum disease during AFib blanking period could reduce recurrence risk

Study evaluates whether treating periodontitis during the blanking period after atrial fibrillation (AF) ablation reduces AF recurrence, revealing that comprehensive periodontal care may significantly diminish recurrence rates by addressing inflammation linked to periodontitis.

12 Apr 2024

Study shows daily glucose levels fluctuate more than we thought, challenging diabetes diagnosis

Study reveals significant fasting glucose variability in nondiabetic adults using continuous glucose monitoring, challenging current diabetes diagnosis criteria and emphasizing the need for multiple measurements to reduce misclassification.

11 Apr 2024

Periodontal treatment after heart rhythm ablation may reduce AFib recurrence

Treating gum disease in the 3-months after a procedure to correct an irregular heartbeat known as atrial fibrillation (AFib) may lower oral inflammation and may reduce AFib recurrence, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

10 Apr 2024

Largest-ever global deployment of cholera rapid diagnostic tests for better disease control

The arrival of rapid diagnostic test (RDT) kits for cholera in Malawi today signals the start of a global programme that will see more than 1.2 million tests distributed to 14 countries at high risk for cholera over the next several months.

10 Apr 2024

Beta-blockers show no benefit for heart attack patients with normal heart function

The REDUCE-AMI trial found that long-term beta-blocker therapy does not reduce mortality risk in acute myocardial infarction patients with preserved left ventricular ejection fraction compared to no beta-blocker treatment.

8 Apr 2024

Revolutionary therapeutic shows promise for pancreatic cancer treatment

A new type of investigational therapeutic in development for pancreatic cancer has shown unprecedented tumor-fighting abilities in preclinical models of the disease, suggesting it has the potential to offer novel treatment options for nearly all pancreatic tumors, a comprehensive study has found.

8 Apr 2024

DEPOSITION trial evaluates the use of topical tranexamic acid during heart surgery

Administering tranexamic acid (TxA), a drug used to reduce bleeding during heart surgery, topically rather than intravenously did not meet its primary endpoint of reducing seizures and was stopped early due to an increased risk of bleeding events, according to research presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Poor oral health linked to negative long-term systemic health outcomes

Those who report having poor oral health are as likely to have negative long-term systemic health outcomes as those previously diagnosed with periodontal disease, or gum disease, according to a new Tufts University School of Dental Medicine study published in The Journal of the American Dental Association.

8 Apr 2024

First-ever guidelines developed to help build a child's tolerance to common food allergens

Researchers with McMaster University have crafted the first-ever guidelines to help prepare families who plan to build their child's tolerance to common food allergens.

8 Apr 2024

Lerodalcibep reduces LDL cholesterol by over 50% in high-risk patients

Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or "bad" cholesterol, levels by more than half on average, compared with a placebo.

8 Apr 2024

Study shows promise of zilebesiran injection in reducing systolic blood pressure

A single subcutaneous injection of the investigational drug zilebesiran, when added to existing treatment with a standard antihypertensive medication, reduced systolic blood pressure by between 4 to 12 mmHg on average at three months in patients whose blood pressure had remained uncontrolled despite compliance with their medication regimen, according to a study presented at the American College of Cardiology's Annual Scientific Session.

7 Apr 2024

Oral spray-based vaccine is a potential alternative to antibiotic treatments for recurrent UTIs

Recurrent Urinary Tract Infections (UTIs) can be prevented for up to nine years in more than half of people given an oral spray-based vaccine and is a potential alternative to antibiotic treatments, finds research.

7 Apr 2024

Oral News and Research

Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

New QR4 algorithm outperforms previous models in predicting cardiovascular disease risk

Does diabetes increase the risk of long COVID?

Greenspace exposure boosts gut and skin microbiota health, study finds

Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

NCCN 2024 Annual Conference focuses on practical applications for improving cancer care

As bans spread, fluoride in drinking water divides communities across the US

Cannabis compound d-limonene reduces anxiety-inducing effects of THC

Treating gum disease during AFib blanking period could reduce recurrence risk

Study shows daily glucose levels fluctuate more than we thought, challenging diabetes diagnosis

Periodontal treatment after heart rhythm ablation may reduce AFib recurrence

Largest-ever global deployment of cholera rapid diagnostic tests for better disease control

Beta-blockers show no benefit for heart attack patients with normal heart function

Revolutionary therapeutic shows promise for pancreatic cancer treatment

DEPOSITION trial evaluates the use of topical tranexamic acid during heart surgery

Poor oral health linked to negative long-term systemic health outcomes

First-ever guidelines developed to help build a child's tolerance to common food allergens

Lerodalcibep reduces LDL cholesterol by over 50% in high-risk patients

Study shows promise of zilebesiran injection in reducing systolic blood pressure

Oral spray-based vaccine is a potential alternative to antibiotic treatments for recurrent UTIs

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