RNA Sequencing News and Research

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Groundbreaking study identifies unique lung cells that may drive pulmonary fibrosis

A groundbreaking study published today and led by the Translational Genomics Research Institute, an affiliate of City of Hope, identifies unique lung cells that may drive Idiopathic Pulmonary Fibrosis, a deadly lung disease that affects hundreds of thousands of Americans, and for which there is no cure.

9 Jul 2020

New study provides insight into the origin and evolution of glioblastoma

Brain cancers have long been thought of as being resistant to treatments because of the presence of multiple types of cancer cells within each tumor. A new study uncovers a cancer cell hierarchy that originates from a single cancer cell type, which can be targeted to slow cancer growth.

8 Jul 2020

Researchers create new tool to identify cancer-causing mutations lurking in 98% of the genome

Gene coding regions constitute 2% of the human genome. St. Jude Children's Research Hospital scientists have developed a computational tool to identify alterations that drive tumor formation in the remaining 98% of the genome.

6 Jul 2020

Researchers develop technique for personalizing stomach cancer therapy

Researchers from the Moscow Institute of Physics and Technology and their colleagues have developed the first technique for personalizing stomach cancer therapy based on RNA sequencing of tumor cells. The study, supported by the Russian Science Foundation, was published in Cold Spring Harbor Molecular Case Studies.

30 Jun 2020

Interactive cloud-based data portal provides access to treasure trove of pediatric solid tumor data

An innovative, interactive cloud-based data portal debuted this week that lets academic researchers mine the world's largest and most comprehensive collection of scientific resources for studying pediatric solid tumors and their related biology.

26 Jun 2020

Researchers discover key signaling pathway in the pathogenesis of Paget's disease

Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of poorly understood malignant skin cancers collectively known as Paget's disease.

26 Jun 2020

Genes associated with SARS-CoV-2 human lung cell infection

Now, a new study published on the preprint server bioRxiv in June 2020 attempts to make sense of this data to identify viral genes that are explicitly expressed in the cells infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This could help reveal new therapeutic targets.

26 Jun 2020

SARS-CoV-2 can replicate in human pediatric gastric organoids

A diverse research group from the United Kingdom, Italy, China, and Australia established a first expandable human gastric organoid culture across fetal developmental stages, supporting the hypothesis that fetal tissue seems to be much less susceptible to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection – especially in the early stages of development.

25 Jun 2020

Researchers develop less invasive genetic tools to understand cellular activity

Graduate student Ubadah Sabbagh placed a cold glass slide on the microscope. It was getting late and the lab was quiet.

24 Jun 2020

Abnormal findings in testicular tissue of COVID-19 patients, SARS-CoV-2 mostly undetected

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 9.263 million cases and taken more than 477,000 lives as of June 24, 2020 – just six months after the initial outbreak in Wuhan, China, was reported. The illness, called COVID-19 disease, caused by SARS-CoV-2 is a severe pneumonic illness, caused by the entry of the virus into the type II alveolar cells.

24 Jun 2020

Female reproductive organs not susceptible to direct SARS-CoV-2 infection

Researchers at the University in San Francisco, California, report that coronavirus disease 2019 (COVID-19) is unlikely to negatively impact on pregnancy-related outcomes such as premature birth, transmission to babies via breast milk, and infertility.

23 Jun 2020

St. Jude scientists create O-PDX models for pediatric brain tumor research

Scientists at St. Jude Children's Research Hospital have created orthotopic patient-derived xenograft (O-PDX) models representing a variety of pediatric brain tumor types.

23 Jun 2020

Long-term endurance training alters the activity of genes involved in metabolic health

Decades-long endurance training alters the activity of genes in human skeletal muscle that are important for metabolic health.

23 Jun 2020

Organoids can help provide new level of accuracy in prescribing anti-cancer therapies

Precision medicine, using the power of the human genome to diagnose and treat patients, is about to get even more precise.

22 Jun 2020

Killifish model helps unravel molecular events that lead to loss of protein homeostasis during brain aging

Aging is the main risk factor for dementia and Parkinson's disease. As age progresses, toxic protein aggregates pile up in the brain and impair neuronal function.

21 Jun 2020

Using stem cells to study the developmental effects of Neandertal DNA

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available.

18 Jun 2020

Study identifies a previously unknown mechanism that contributes to intestinal cancer

A MedUni Vienna study group has identified a previously unknown mechanism involved in the development of intestinal cancer: The bacterial microbiome activates the so-called immune checkpoint Ido1 in Paneth cells, a special cell that is only found in the gastrointestinal tract, thereby preventing local intestinal inflammation.

18 Jun 2020

Scientists evaluate SARS-CoV-2 infection risks in livestock, poultry, pets and wildlife

A large-scale single-cell screening endeavor on a wide variety of animals showed that cells targeted by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are most abundant in cats, but are also found in other animals – unveiling a valuable resource for controlling the ongoing disruptive coronavirus disease (COVID-19) pandemic.

16 Jun 2020

Accelerating the Diagnosis and Treatment of Cancer with Mass-Spectrometry Based Techniques

An interview with Livia Eberlin, Assistant Professor at the University of Texas at Austin, discussing the development of mass-spectrometry based techniques for cancer diagnosis and improved clinical outcomes.

From Pittcon 16 Jun 2020

Ashion Analytics is now part of NCI's MATCH cancer clinical trials

Ashion Analytics, a clinical laboratory of the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, is now part of the National Cancer Institute's MATCH program, which provides patients who have rare or difficult-to-treat cancers with access to unique clinical trials nationwide that might give them the best therapeutic treatments and outcomes.

12 Jun 2020

RNA Sequencing News and Research

Groundbreaking study identifies unique lung cells that may drive pulmonary fibrosis

New study provides insight into the origin and evolution of glioblastoma

Researchers create new tool to identify cancer-causing mutations lurking in 98% of the genome

Researchers develop technique for personalizing stomach cancer therapy

Interactive cloud-based data portal provides access to treasure trove of pediatric solid tumor data

Researchers discover key signaling pathway in the pathogenesis of Paget's disease

Genes associated with SARS-CoV-2 human lung cell infection

SARS-CoV-2 can replicate in human pediatric gastric organoids

Researchers develop less invasive genetic tools to understand cellular activity

Abnormal findings in testicular tissue of COVID-19 patients, SARS-CoV-2 mostly undetected

Female reproductive organs not susceptible to direct SARS-CoV-2 infection

St. Jude scientists create O-PDX models for pediatric brain tumor research

Long-term endurance training alters the activity of genes involved in metabolic health

Organoids can help provide new level of accuracy in prescribing anti-cancer therapies

Killifish model helps unravel molecular events that lead to loss of protein homeostasis during brain aging

Using stem cells to study the developmental effects of Neandertal DNA

Study identifies a previously unknown mechanism that contributes to intestinal cancer

Scientists evaluate SARS-CoV-2 infection risks in livestock, poultry, pets and wildlife

Accelerating the Diagnosis and Treatment of Cancer with Mass-Spectrometry Based Techniques

Ashion Analytics is now part of NCI's MATCH cancer clinical trials

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