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SARS-CoV-2-encoded protein ameliorates neuromuscular degeneration in fly models of neurodegenerative diseases

Researchers explored the in vivo efficacy of SARS-CoV-2-encoded proteins against neuromuscular degeneration associated with ribosome stalling.

3 Oct 2022

Sleep disparities may impact health in minority communities

Minority and low-income communities face a sleep gap that can damage their health.

29 Sep 2022

Scientists visualize antibiotics in action inside a pathogenic bacterium

Every living cell relies on proteins in order to function and the process of protein synthesis – translation – is critical for survival.

28 Sep 2022

Genome editing approaches enable precise gene correction and disease rescue in inherited retinal diseases

In a new paper, University of California, Irvine researchers explain how precision genome editing agents have enabled precise gene correction and disease rescue in inherited retinal diseases (IRDs).

23 Sep 2022

Investigating a potential new treatment for glioblastomas

A research question posed in Pankaj Desai's lab has led to a decade of research, a clinical trial and major national funding to further investigate a potential new treatment for the most deadly form of brain tumors.

23 Sep 2022

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Researchers described a novel antiviral mechanism of action for an FDA (food and drug administration)-approved thiopurine known as 6-thioguanine (6-TG).

21 Sep 2022

Many refugees dealing with trauma face obstacles to mental health care

As a young boy living in what was then Zaire, Bertine Bahige remembers watching refugees flee from the Rwandan genocide in 1994 by crossing a river that forms the two Central African nations' border.

19 Sep 2022

Study identifies a promising target for polycystic kidney disease treatment

Blocking the inhibition of PKD1 and PKD2 gene expression by deleting a binding site for microRNAs hindered the formation and growth of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD) models, UT Southwestern researchers reported.

16 Sep 2022

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

In a recent study posted to the medRxiv* preprint server, researchers in Australia determined whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta-ORF7aΔ17del [open reading frame 7a protein with 17-nucleotide (nt) frameshift-inducing deletion] variant has a fitness advantage over the Delta variant lacking the ORF7aΔ17del deletion (Delta-ORF7aintact) and/or the SARS-CoV-2 lineage (A.2.2).

12 Sep 2022

Small molecule inhibitor found to be effective against SARS-CoV-2 variants

In a new study, researchers developed RK-33, a small molecule inhibitor of DDX3, and evaluated its efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs).

12 Sep 2022

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Based on findings from a new study by a Johns Hopkins Medicine-led research team, an effective means of fighting SARS-CoV-2, the virus that causes COVID-19, may be possible that circumvents the problem of waning immunity often observed when current vaccines deal with emerging COVID variants.

8 Sep 2022

Wearable assistive robot can detect and prevent a fall before it happens

Researchers at Nanyang Technological University, Singapore (NTU Singapore) and Tan Tock Seng Hospital (TTSH) have developed a wearable assistive robot that can detect and prevent a fall before it happens, reducing the user's risk of sustaining injuries.

7 Sep 2022

dsDNA Quantification for NGS Quality Control

Andrew Jones discusses the importance of quality control in NGS and the effect that a poorly followed protocol can have on experimental results.

From DeNovix Inc. 1 Sep 2022

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial mutations to observe these tiny organelles.

30 Aug 2022

3 shots in 1: How microparticles could be used to deliver self-boosting vaccines

In this interview, we speak to Morteza Sarmadi from MIT about his labs latest research that developed microparticles able to deliver self-boosting vaccines.

30 Aug 2022

Study reveals a 'stealing' mechanism that contributes to antibody diversity

A few years ago, Professor Kathrin de la Rosa and her colleagues in the lab of the Swiss immunologist Antonio Lanzavecchia made an unusual discovery.

29 Aug 2022

Regenstrief research scientist voted president-elect of the American Delirium Society

Regenstrief Research Scientist Noll Campbell, PharmD, M.S., has been voted president-elect of the American Delirium Society (ADS) by the board of directors. Dr. Campbell will be installed into office in conjunction with the society's national conference in June of 2023.

29 Aug 2022

Viruses modify host cellular machinery to produce high amounts of viral progeny

The study, published in Nature Communications, shows a new mechanism whereby viruses modify cellular machinery so that it can better read the instructions in the genome of the invading virus.

29 Aug 2022

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

The W.M. Keck Foundation has awarded a $1.2 million grant to medicinal chemistry and computational biology researchers at the University of Kansas and the University of Chicago focused on addressing a long-unresolved problem in biomedical research - finding molecules able to target the "undruggable proteome."

29 Aug 2022

Three-drug medication effective in preventing recurrent cardiovascular events after a heart attack

A three-drug medication known as a "polypill," developed by the Spanish National Center for Cardiovascular Research (CNIC) and Ferrer, is effective in preventing secondary adverse cardiovascular events in people who have previously had a heart attack, reducing cardiovascular mortality by 33 percent in this patient population.

26 Aug 2022

Translation News and Research

SARS-CoV-2-encoded protein ameliorates neuromuscular degeneration in fly models of neurodegenerative diseases

Sleep disparities may impact health in minority communities

Scientists visualize antibiotics in action inside a pathogenic bacterium

Genome editing approaches enable precise gene correction and disease rescue in inherited retinal diseases

Investigating a potential new treatment for glioblastomas

New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine

Many refugees dealing with trauma face obstacles to mental health care

Study identifies a promising target for polycystic kidney disease treatment

First report of a SARS-CoV-2 variant with an ORF7a deletion that dominated an outbreak

Small molecule inhibitor found to be effective against SARS-CoV-2 variants

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Wearable assistive robot can detect and prevent a fall before it happens

dsDNA Quantification for NGS Quality Control

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

3 shots in 1: How microparticles could be used to deliver self-boosting vaccines

Study reveals a 'stealing' mechanism that contributes to antibody diversity

Regenstrief research scientist voted president-elect of the American Delirium Society

Viruses modify host cellular machinery to produce high amounts of viral progeny

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

Three-drug medication effective in preventing recurrent cardiovascular events after a heart attack

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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