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Single-cell sequencing reveals why some CAR-T therapies succeed while others fail

Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses.

30 Apr 2026

Metabolic rewiring could help CAR-T cells fight solid tumors

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.

29 Apr 2026

How multi-omics is changing what scientists can see in the human immune system

Human systems immunology is using multi-omics, single-cell tools, spatial technologies, and AI to decode immune responses across real-world human cohorts. The review highlights major opportunities for biomarker discovery and precision medicine, while stressing the need for rigorous study design, validation, and careful interpretation.

29 Apr 2026

New imaging agent shows promise for non-invasive endometriosis diagnosis

The Nuffield Department of Women's & Reproductive Health at the University of Oxford, together with Serac Healthcare Limited announces the publication of Phase 2 data in The Lancet Obstetrics and Gynaecology.

29 Apr 2026

Brief walking breaks help the body control sugar after carb-rich meals

Brief brisk walking breaks during prolonged sitting improved post-meal interstitial glucose responses in healthy adults after carbohydrate-rich meals, with the strongest effects seen in women. Gluteal fat showed a more stable glucose pattern than abdominal fat, suggesting it may help buffer carbohydrate-related glucose rises through depot-specific uptake and lipid-synthesis pathways.

29 Apr 2026

AHA calls for lifelong brain health strategy to prevent cognitive decline

The AHA scientific statement calls for a life-course approach to brain health that integrates cognitive, emotional, behavioral, vascular, environmental, inflammatory, sleep, microbiome, and social factors. It highlights how early-life exposures, mental health, pollution, chronic inflammation, poor sleep, gut dysbiosis, and socioeconomic adversity may shape brain resilience and later-life cognitive decline.

29 Apr 2026

Researchers use light-activated nanozymes to treat aggressive brain tumors

Brain tumors cannot always be successfully treated with conventional therapies. A team from Empa and the hospital network HOCH Health Ostschweiz is therefore developing nanozymes that can attack cancer cells directly in the brain during tumor surgery.

29 Apr 2026

New genetic risk test estimates inherited risk for cardiovascular conditions

Researchers at Mass General Brigham Heart and Vascular Institute and collaborators have developed and validated a new genetic risk test that can estimate a person's inherited risk for eight common cardiovascular conditions, offering a more comprehensive approach to prevention.

29 Apr 2026

New hybrid molecule uses Trojan horse approach to treat obesity

A team led by metabolism researcher Prof Timo D. Müller at Helmholtz Munich has developed a new approach for treating obesity and type 2 diabetes: a hybrid molecule uses the well-known GLP-1/GIP signalling pathway as a "door opener" and delivers an additional metabolic modulator specifically into the target cells.

29 Apr 2026

Eating creates temporary metabolic state that boosts T cell function

Diets and healthy eating habits hold promise for preventing and treating diseases, but far less is known about acute effects to the immune system shortly after a meal.

29 Apr 2026

Nerve fibers within melanomas found to slow tumor growth

Nerve fibers within melanomas can slow the growth of these tumors, according to a study led by Weill Cornell Medicine investigators.

29 Apr 2026

New map reveals B cell clusters linked to faster diabetic kidney disease

A detailed new map of the human kidney revealed a previously unrecognized form of diabetic kidney disease (DKD) marked by clusters of immune cells-specifically B cells-that are linked to faster disease progression.

29 Apr 2026

Diatron introduces advanced RUO indices on its Aquila, Aquarius 3, Abacus 5 analyzers

Diatron, a STRATEC brand specializing in the development, manufacturing, and marketing of hematology and clinical chemistry analyzers and related reagents for human and veterinary use, expands the capabilities of its Aquila, Aquarius 3, and Abacus 5 hematology analyzers with six advanced hematological indices.

From Diatron 29 Apr 2026

AI eye screening shows promise for detecting six metabolic diseases

Researchers developed Reti-Pioneer, an AI retinal imaging framework that screened for six endocrine and metabolic diseases using color fundus photographs and clinical metadata. The system showed moderate-to-strong performance across cohorts, improved specialist decision-making, and demonstrated promising, though still preliminary, potential for faster, scalable disease screening.

29 Apr 2026

Scientists redesign CAR-T cells to fight more than cancer

This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic viral infections, and next-generation immune-cell platforms. It highlights promising engineering advances, including universal CAR-T cells, in vivo delivery, CAR-NK cells, and safety switches, while emphasizing unresolved challenges in durability, safety, scalability, and global access.

29 Apr 2026

Cumulative cardiovascular health from early adulthood predicts lower disease risk

The American Heart Association's Life's Essential 8 (LE8) score is a health tool, ranging from 0 to 100, that quantifies cardiovascular health (CVH) using information from eight lifestyle and risk factors, (body mass index, cholesterol, blood pressure, blood glucose, physical activity, diet, smoking, and sleep.

28 Apr 2026

Wearable sweat sensor tracks vitamin levels in real time

Researchers developed a wearable electrochemical patch that detects six vitamins in sweat at nanomolar levels, combining sweat induction, microfluidic sampling, wireless readout, and pH/ionic-strength calibration. Human testing focused mainly on vitamin B9, showing sweat levels rose after supplementation or a vitamin B9-rich diet and correlated with serum levels, supporting future use for non-invasive nutrition trend monitoring.

28 Apr 2026

New blood-based method identifies testicular cancer missed by standard tests

Mayo Clinic researchers have developed a blood-based method that may help detect germ cell tumors, the most common type of testicular cancer, including cases that do not show up on standard blood tests, according to a study published in Nature Communications.

28 Apr 2026

Lab-grown skin organoids provide new insights into blood vessel pathology

New research has shown that single blood vessel cells that appear in the earliest stages of lab-grown skin organoids have the ability to form complex microvascular networks that grow and mature over time.

28 Apr 2026